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1821por Usui, Genki, Shinozaki, Tomohiro, Jinno, Toyohisa, Fujibayashi, Kazutoshi, Morikawa, Teppei, Gunji, Toshiaki, Matsuhashi, Nobuyuki“…The hazards of progression to LSBE were compared between time-varying RE and H. pylori infection/eradication by time-dependent multivariable Cox proportional hazards models. RESULTS: A total of 7637 subjects who underwent additional medical check-ups after being diagnosed with endoscopic SSBE were analyzed. …”
Publicado 2020
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1822por Vergani, Elisabetta, Dugo, Matteo, Cossa, Mara, Frigerio, Simona, Di Guardo, Lorenza, Gallino, Gianfrancesco, Mattavelli, Ilaria, Vergani, Barbara, Lalli, Luca, Tamborini, Elena, Valeri, Barbara, Gargiuli, Chiara, Shahaj, Eriomina, Ferrarini, Marina, Ferrero, Elisabetta, Gomez Lira, Macarena, Huber, Veronica, Vecchio, Michele Del, Sensi, Marialuisa, Leone, Biagio Eugenio, Santinami, Mario, Rivoltini, Licia, Rodolfo, Monica, Vallacchi, Viviana“…Similar effects were obtained by inhibiting COX2 by celecoxib, a clinically approved COX2 inhibitor. …”
Publicado 2020
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1823por Szczukowski, Łukasz, Krzyżak, Edward, Zborowska, Adrianna, Zając, Patrycja, Potyrak, Katarzyna, Peregrym, Krzysztof, Wiatrak, Benita, Marciniak, Aleksandra, Świątek, Piotr“…According to in vitro evaluations, novel molecules exert no cytotoxicity and act as selective COX-2 inhibitors. These findings stay in good correlation with molecular modeling results, which additionally showed that investigated compounds take a position in the active site of COX-2 very similar to Meloxicam. …”
Publicado 2020
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1824“…The response variable was the time from admission to discharge of patients. Cox proportional hazard model was used to identify the factors that were associated with the length of hospital stay. …”
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1825por Zhan, Zhucheng, Jing, Zheng, He, Bing, Hosseini, Noshad, Westerhoff, Maria, Choi, Eun-Young, Garmire, Lana X“…We compare this model with the conventional Cox proportional hazards (Cox-PH) model, CoxBoost, Random Survival Forests and DeepSurv, using C-index and log-rank P-values. …”
Publicado 2021
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1826por Jiang, Liyuan, Cao, Yong, Yin, Xianzhen, Ni, Shuangfei, Li, Miao, Li, Chengjun, Luo, Zixiang, Lu, Hongbin, Hu, Jianzhong“…In this study, to obtain high-resolution 3D imaging of a detailed neuronal network in the mass of the spinal cord, the combination of synchrotron radiation micro-computed tomography (SRμCT) and the Golgi-cox staining were used. We optimized the Golgi-Cox method (GCM) and developed a modified GCM (M-GCM), which improved background staining, reduced the number of artefacts, and diminished the impact of incomplete vasculature compared to the current GCM. …”
Publicado 2021
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1827por Chen, Minjie, Sun, Xicui, Wei, Wei, Cucarella, Carme, Martín-Sanz, Paloma, Casado, Marta, Pi, Liya, Ren, Bin, Cao, Qi“…Constitutive hepatic cyclooxygenase-2 (COX-2) expression could protect from high fat-induced metabolism disturbance in a murine model. …”
Publicado 2021
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1828por Du, Li, Wang, Honglei, Liu, Fang, Wei, Zeyu, Weng, Changjiang, Tang, Jun, Feng, Wen-hai“…Prostaglandin E2 (PGE2) derived from arachidonic acid through the activation of the rate-limiting enzyme cyclooxygenase type 1/2 (COX-1/2) plays an important role in fever. Here, we showed that HP-PRRSV infection increased PGE2 production in microglia via COX-2 up-regulation depending on the activation of MEK1-ERK1/2-C/EBPβ signaling pathways. …”
Publicado 2021
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1829por Lam, Steven H., So, Ho, Cheng, Isaac T., Li, Edmund K., Wong, Priscilla, Li, Tena K., Lee, Alex Pui-Wai, Tam, Lai-Shan“…Framingham risk score (FRS) was used to quantify the traditional CV risk. Cox proportional hazard models with time-varying CRP levels and drugs used were analysed to identify the risk factors for CV events in PsA patients. …”
Publicado 2021
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1830“…In a multivariate cox regression analysis, the following factors were associated with better primary gastric patients survival (Surgical method, Age at diagnosis, histological grade). …”
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1831por Luo, Zhiqiang, Ma, Yanchao, Di, Tianning, Ma, Bing, Li, Hongwei, An, Jiangdong, Wang, Yonggang, Zhang, Haihong“…Mechanistically, DNMT3B modified the TRPA1 promoter by methylation to inhibit the expression of COX2. Overexpression of COX2 promoted the apoptosis of NP cells and decreased the expression of YAP, which was reversed by upregulating DNMT3B. …”
Publicado 2021
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1832por Carola, Christophe, Salazar, Andrew, Rakers, Christin, Himbert, Franck, Do, Quoc-Tuan, Bernard, Philippe, von Hagen, Joerg“…Additionally, the same cornflower extract in another vehicle was evaluated in parallel with N-feruloylserotonin for cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LOX) enzymatic cellular inhibition. …”
Publicado 2021
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1833por Hu, Xin, Zhang, Ye-An, Chen, Ben, Jin, Zi, Lin, Mei-Lin, Li, Ming, Mei, Hong-Xia, Lu, Jia-Chao, Gong, Yu-Qiang, Jin, Sheng-Wei, Zheng, Sheng-Xing“…PURPOSE: Acute respiratory distress syndrome (ARDS) is characterized by uncontrollable inflammation. Cyclooxygenase-2(COX-2) and its metabolite prostaglandins are known to promote the inflammatory resolution of ARDS. …”
Publicado 2022
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1834por Amin, Nuhu, Rahman, Mahbubur, Alam, Mahbub-Ul, Shoab, Abul Kasham, Alome, Md. Kawsar, Amin, Maksudul, Huda, Tarique Md. Nurul, Unicomb, Leanne“…A mixed-method, small-scale before-and-after field trial assessed the accuracy and consistency of an automated chlorinator, Zimba, in Rohingya camp housing, Cox’s Bazar. From August–September 2018, two shallow tubewells (iron concentration = 6.5 mg/L and 1.5 mg/L) were selected and 20 households were randomly enrolled to participate in household surveys and water testing. …”
Publicado 2021
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1835por Mittraphab, Yanisa, Amen, Yhiya, Nagata, Maki, Matsumoto, Masako, Wang, Dongmei, Shimizu, Kuniyoshi“…Protocatechuic acid (2), epicatechin (4), and kaempferol (11) at a concentration 100 μM increased the HaCaT cells viability of the UVB-irradiated cell without any cytotoxicity effect and reduced the expression of COX-2 and iNOS inflammation gene. Moreover, compounds 2 and 4 could have potent effects on cell migration during wound closure. …”
Publicado 2022
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1836“…This was verified further by the partial restoration of mitochondrial ATP synthase assembly in atp23 null mutant transformed with exogenous hybrid COX1 T1121G mutant plasmid. The predicted tertiary structure of the Cox1 p.Val374Gly mutation showed no obvious difference from wild-type Cox1. …”
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1837por Schuldt, Lisa, Reimann, Michael, von Brandenstein, Katrin, Steinmetz, Julia, Döding, Annika, Schulze-Späte, Ulrike, Jacobs, Collin, Symmank, Judit“…UNC1999-induced H3K27me3 inhibition reversed the hyperinflammatory responses of dual-stressed PA cultures characterized by increased COX2 expression, PGE2 secretion and THP1 adhesion. …”
Publicado 2022
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1838por Hamed, A. M. R., Abdel-Shafi, I. R., Elsayed, M. D. A., Mahfoz, A. M., Tawfeek, S. E., Abdeltawab, M. S. A.“…Also, assessment of the local expression of cyclooxygenase-2 enzyme (COX-2) and CD34 in these samples was done by immunohistochemistry. …”
Publicado 2022
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1839por Saiyed, Nasrin S, Yagoub, Umar, Al Qahtani, Bandar, Al Zahrani, Attiya Mohammed, Al Hariri, Ibrahim, Syed, Meerab Javed, Elmardi, Mohammed Elmujtaba, Tufail, Muhammad Abdullah, Manajreh, Marwan“…Descriptive statistics and Cox proportional hazards models were used for data analysis. …”
Publicado 2022
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1840“…Meanwhile, kaempferol displayed prominent dose-dependent inhibition against COX-2 with IC(50) value at 0.36 ± 0.02 μM lower than indomethacin at 0.73 ± 0.07 μM. …”
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