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  1. 3921
    “…Through CpG methylome and expression profiling, a developmental transcription factor - Hand-And-Neural-crest-Derivative-expressed 1 (HAND1), was identified methylated and downregulated in GC. …”
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    The developmental regulator HAND1 inhibits gastric carcinogenesis through enhancing ER stress apoptosis via targeting CHOP and BAK which is augmented by cisplatin
  2. 3922
    “…To understand the cellular mechanism of CHARGE syndrome, neural crest cells (NCCs), that contribute to craniofacial and cardiovascular tissues, are examined using sox10:Cre lineage tracing. …”
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    Craniofacial and cardiac defects in chd7 zebrafish mutants mimic CHARGE syndrome
  3. 3923
    “…Loss of TGF-β signaling in the neural crest-derived palatal mesenchyme leads to defects in perimysial fibroblasts and muscle malformation in the soft palate in Osr2(Cre);Tgfbr1(fl/fl) mice. …”
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    TGF-β signaling and Creb5 cooperatively regulate Fgf18 to control pharyngeal muscle development
  4. 3924
    “…Nevertheless, the distance from the sinus floor to the alveolar bone crest is not correlated with skeletally sagittal or vertical parameters in females but negatively correlated with the skeletal sagittal parameter in males. …”
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    Maxillary Sinus Dimensions in Skeletal Class I Chinese Population with Different Vertical Skeletal Patterns: A Cone-Beam Computed Tomography Study
  5. 3925
    “…All cases but two showed homolateral flank closure (lower rib descent, iliac crest raise and/or homolateral side-bending). The correction of nephroptosis, either by supine position or surgical treatment, removed asymmetries in some cases while other cases improved only partly. …”
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    A Systematic Review on Spinal Asymmetries in Case Studies of Unilateral Nephroptosis from a Viscerosomatic Point of View
  6. 3926
    “…INTRODUCTION: Bertolotti’s syndrome (BS) is defined as the presence of low back pain (LBP), radiculopathy or both with a dysplastic transverse process (TP) of the fifth lumbar vertebra that is articulated or fused with the sacral base or iliac crest. This study aimed to investigate the prevalence and severity of BS to promote awareness of this disease. …”
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    Prevalence and severity of Bertolottis syndrome in Malaysia: A common under diagnosis
  7. 3927
    “…If the bridge distance was 18 mm longer, the non-rigid connection of the three-piece abutment could maintain the physiological movement of the natural tooth and avoid the excessive stress on the bone crest around the implant.…”
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    Biomechanical evaluation of bridge span with three implant abutment designs and two connectors for tooth-implant supported prosthesis: A finite element analysis
  8. 3928
    “…In mice (<12 h old) exposed to hyperoxia during the saccular stage followed by air recovery until adulthood, lung senescence increased particularly in type II cells and secondary crest myofibroblasts. This peaked during the alveolar stage and was mediated by the p53/p21 pathway. …”
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    Timing and cell specificity of senescence drives postnatal lung development and injury
  9. 3929
    “…The vertical distance from alveolar crest (H(cre)) and inferior border of mandible (H(inf)) to the LF, horizontal distance from lingual canal to labial cortical plate (LC-CP), length of the lingual canal (LLC) and diameter of the LF were measured. …”
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    Three-dimensional assessment of the mandibular lingual foramina with implications for surgical and implant therapy: A multicentre cross-sectional study
  10. 3930
    “…Neuroblastoma (NB) is a common type of cancer found mostly in infants and arising from the immature neural crest cells of the sympathetic nervous system. Using laser trapping (LT) technique, the present work contributes to advancing radiotherapy (RT), a leading treatment method for cancer. …”
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    The radiation response measurement of a single and multiple cell ionization of neuroblastoma cells by infrared laser trap
  11. 3931
    “…To address how osteoprogenitors interact with the observed FN1 prepattern, we conditionally ablate Wasl/N-Wasp to disrupt F-actin junctions in migrating cells, impacting lamellipodia and cell-matrix interaction. Neural crest-targeted deletion of Wasl results in a diminished actin network and reduced expansion of frontal bone primordia similar to conditional Fn1 mutants. …”
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    Apical expansion of calvarial osteoblasts and suture patency is dependent on graded fibronectin cues
  12. 3932
    “…We subsequently identified 6 individuals from 3 additional kindreds with microtia-CFM spectrum phenotypes harboring damaging variants in FOXI3, a regulator of ectodermal and neural crest development. Missense variants in the nuclear localization sequence were identified in cases with isolated microtia with aural atresia and found to affect subcellular localization of FOXI3. …”
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    Damaging variants in FOXI3 cause microtia and craniofacial microsomia
  13. 3933
    “…Losses and malformations of cranial neural crest cell (cNCC) derivatives are a hallmark of several common brain and face malformations. …”
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    High‐throughput detection of craniofacial defects in fluorescent zebrafish
  14. 3934
    “…The mineral apposition rate of the alveolar bone crest was higher in the CO(3)Ap group than in the control and β-TCP groups. …”
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    Preclinical evaluation of the effect of periodontal regeneration by carbonate apatite in a canine one-wall intrabony defect model
  15. 3935
    “…The MES-like state shared strong transcriptional overlap with ganglioneuroma (GN), a benign and highly differentiated tumor of the neural crest. Mechanistically, ISX suppressed chromatin binding of N-MYC, a CRC-amplifying transcription factor, resulting in loss of key ADRN subtype-enriched components such as N-MYC itself, PHOX2B and ALK, while concomitently, MES subtype markers were induced. …”
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    Tumor-suppressive disruption of cancer subtype-associated super enhancer circuits by small molecule treatment
  16. 3936
    “…Fate mapping and histological studies also showed increased numbers of neural crest–derived cells accompanied by increased collagen deposition in the kidneys of Prdm6(fl/+) Wnt1Cre-ZsGreen1Cre mice compared with WT mice. …”
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    A systems biology approach identifies the role of dysregulated PRDM6 in the development of hypertension
  17. 3937
    “…In this study, we investigated the role of Six1 in mandible development using a Six1 knockout mouse model (Six1 ( −/− )) and a cranial neural crest-specific, Six1 conditional knockout mouse model (Six1 ( f/f ) ; Wnt1-Cre). …”
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    Ectomesenchymal Six1 controls mandibular skeleton formation
  18. 3938
    “…Three critical processes must happen for efficient pigmentation: (1) melanosome biogenesis in neural crest-derived melanocytes, (2) the biochemical synthesis of melanins (melanogenesis) inside melanosomes, and (3) the transfer of melanin granules to surrounding pre-cortical keratinocytes for their incorporation into nascent hair fibres. …”
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    A Comprehensive Review of Mammalian Pigmentation: Paving the Way for Innovative Hair Colour-Changing Cosmetics
  19. 3939
    “…Melanoma is a highly metastatic tumour originating from neural crest-derived melanocytes. The aim of this study was to analyse the expression of neuron navigator 3 (NAV3) in relation to membrane type-1 matrix metalloproteinase MMP14, a major regulator of invasion, in 40 primary melanomas, 15 benign naevi and 2 melanoma cell lines. …”
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    Tumour Suppressor Neuron Navigator 3 and Matrix Metalloproteinase 14 are Co-expressed in Most Melanomas but Downregulated in Thick Tumours
  20. 3940
    “…Genetic lineage tracing in Hoxa1(−/−) mutant mice reveals an abnormal reduction of neural crest-derived cells in the valve leaflet, which is caused by a failure of early migration of these cells.…”
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    Variations in the poly-histidine repeat motif of HOXA1 contribute to bicuspid aortic valve in mouse and zebrafish
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