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4501por Lin, Cliff, Zhang, Nianli, Waldorff, Erik I., Punsalan, Paolo, Wang, David, Semler, Eric, Ryaby, James T., Yoo, Jung, Johnstone, Brian“…METHODS: We aim to compare the ability of six commercially‐available human CBMs (Trinity ELITE®, ViviGen®, Cellentra®, Osteocel® Pro, Bio4® and Map3®) to form a stable spinal fusion using an athymic rat model of posterolateral fusion. Iliac crest bone from syngeneic rats was used as a control to approximate the human gold standard. …”
Publicado 2020
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4502por Eura, Nobuyuki, Matsui, Takeshi K., Luginbühl, Joachim, Matsubayashi, Masaya, Nanaura, Hitoki, Shiota, Tomo, Kinugawa, Kaoru, Iguchi, Naohiko, Kiriyama, Takao, Zheng, Canbin, Kouno, Tsukasa, Lan, Yan Jun, Kongpracha, Pornparn, Wiriyasermkul, Pattama, Sakaguchi, Yoshihiko M., Nagata, Riko, Komeda, Tomoya, Morikawa, Naritaka, Kitayoshi, Fumika, Jong, Miyong, Kobashigawa, Shinko, Nakanishi, Mari, Hasegawa, Masatoshi, Saito, Yasuhiko, Shiromizu, Takashi, Nishimura, Yuhei, Kasai, Takahiko, Takeda, Maiko, Kobayashi, Hiroshi, Inagaki, Yusuke, Tanaka, Yasuhito, Makinodan, Manabu, Kishimoto, Toshifumi, Kuniyasu, Hiroki, Nagamori, Shushi, Muotri, Alysson R., Shin, Jay W., Sugie, Kazuma, Mori, Eiichiro“…Here, we developed a method to generate human brainstem organoids (hBSOs), containing midbrain/hindbrain progenitors, noradrenergic and cholinergic neurons, dopaminergic neurons, and neural crest lineage cells. Single-cell RNA sequence (scRNA-seq) analysis, together with evidence from proteomics and electrophysiology, revealed that the cellular population in these organoids was similar to that of the human brainstem, which raises the possibility of making use of hBSOs in investigating central nervous system disorders affecting brainstem and in efficient drug screenings.…”
Publicado 2020
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4503por Sghaireen, Mohammed G., Srivastava, Kumar Chandan, Shrivastava, Deepti, Ganji, Kiran Kumar, Patil, Santosh R., Abuonq, Anas, Mousa, Mohammed Assayed, Dar-Odeh, Najla, Sghaireen, Ghazi M., Kamal, Mohammad Amjad, Alam, Mohammad Khursheed“…The three dimensions, i.e., the linear distance from the outer buccal cortical plate to the inferior alveolar nerve (BCPN), linear distance from the outer lingual cortical plate to the inferior alveolar nerve (LCPN) and linear distance from the midpoint of the alveolar crest to the inferior alveolar nerve (ACN) were assessed. …”
Publicado 2020
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4504por Moses, C., Hodgetts, S. I., Nugent, F., Ben-Ary, G., Park, K. K., Blancafort, P., Harvey, A. R.“…The CRISPR system also worked more effectively than shRNAs for Pten repression in rat neural crest-derived PC-12 cells, and enhanced neurite outgrowth after nerve growth factor stimulation. …”
Publicado 2020
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4505“…Expression of mesenchymal Bmp7 is observed at sites where mineralization is initiated, in tooth cusps of developing molars. Neural crest-specific deletion of Bmp7 (Bmp7(ncko)) resulted in a complete lack of dentin/enamel formation at birth, the time when mineralization is normally initiated in the upper molars, similar to what was observed in Bmp2(ncko) mice. …”
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4506por Tesfaye, Tinsae Shemelise, Zeleke, Tadesse Mekonen, Alemu, Wagaye, Argaw, Dirshaye, Bedane, Tadesse Kebebe“…Waist circumference was measured using a flexible metric tape mid-way between the lowest rib and iliac crest with the participant standing at the end of gentle expiration. …”
Publicado 2020
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4507por Wood, Katherine A., Rowlands, Charlie F., Thomas, Huw B., Woods, Steven, O’Flaherty, Julieta, Douzgou, Sofia, Kimber, Susan J., Newman, William G., O’Keefe, Raymond T.“…Here we reprogrammed peripheral mononuclear blood cells from a BMKS patient and her unaffected mother into induced pluripotent stem cells (iPSCs) and differentiated the iPSCs into induced neural crest cells (iNCCs), the key cell type required for correct craniofacial development. …”
Publicado 2020
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4508por Almansour, Haidara, Jacoby, Johann, Baumgartner, Heiko, Reumann, Marie K., Nikolaou, Konstantin, Springer, Fabian“…Six percent of the pins were applied through the tibial crest and 1% anterolaterally. Of those 85 pins, 42 pins (49%) injured the TNAC at least partially. …”
Publicado 2020
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4509“…In addition to insulin-induced PI3K/AKT activity, which was either transient or sustainable depending on the cell line, an insulin-triggered increase in the percentage of cells expressing NGFR, a marker of neural crest stem-like cells, may contribute to the reduced drug efficacy. …”
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4510por Schierz, Ingrid Anne Mandy, Cimador, Marcello, Giuffrè, Mario, Aiello, Claudia Maria, Antona, Vincenzo, Corsello, Giovanni, Piro, Ettore“…BACKGROUND: Hirschsprung disease, the most important congenital colonic dysmotility in children results from neural crest migration, differentiation, proliferation, or apoptosis defects where the rearranged during transfection (RET)-Protooncogene pathway has a central role. …”
Publicado 2020
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4511por Putra, Ramadhan Hardani, Yoda, Nobuhiro, Iikubo, Masahiro, Kataoka, Yoshihiro, Yamauchi, Kensuke, Koyama, Shigeto, Cooray, Upul, Astuti, Eha Renwi, Takahashi, Tetsu, Sasaki, Keiichi“…CONCLUSIONS: Low bone density and/or narrow bucco-lingual width near the alveolar bone crest in the implant placement site might be a risk factor influencing the accuracy of implant placement with CGS.…”
Publicado 2020
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4512“…The changes are related explicitly to secondary crest formation that may result in alteration in lung elastin. …”
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4513por Wei, Cheng-Jiang, Gu, Yi-Hui, Wang, Wei, Ren, Jie-Yi, Cui, Xi-Wei, Lian, Xiang, Liu, Jin, Wang, Hui-Jing, Gu, Bin, Li, Qing-Feng, Wang, Zhi-Chao“…Nevertheless, all these neural crest-originated neoplasms show some similarities in the tumor microenvironment, indicating that studies of one subtype of neurogenic tumor might assist in clarifying the underlying mechanisms of other subtypes. …”
Publicado 2020
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4514por Magogo, Juma, Lazaro, Albert, Mango, Mechris, Zuckerman, Scott L., Leidinger, Andreas, Msuya, Salim, Rutabasibwa, Nicephorus, Shabani, Hamisi K., Härtl, Roger“…Cervical operations included 4 (17%) anterior cervical discectomy and fusion with plate, 7 (30%) anterior cervical corpectomy with tricortical iliac crest graft and plate, and 12 (52%) posterior cervical laminectomy and fusion with lateral mass screws. …”
Publicado 2020
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4515por Tang, Tao, Donnelly, Christopher R., Shah, Amol A., Bradley, Robert M., Mistretta, Charlotte M., Pierchala, Brian A.“…To determine whether the developmental functions of p75 in geniculate neurons are cell autonomous, we deleted p75 specifically in Phox2b + oral sensory neurons (Phox2b-Cre; p75(fx/fx)) or in neural crest-derived cells (P0-Cre; p75(fx/fx)) and examined geniculate neuron development. …”
Publicado 2020
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4516por Hulme, Amy J., McArthur, Jeffrey R., Maksour, Simon, Miellet, Sara, Ooi, Lezanne, Adams, David J., Finol-Urdaneta, Rocio K., Dottori, Mirella“…The optimized protocol described here generates sensory neurons from hPSC-derived neural crest (NC) progenitors through virally induced NGN2 expression. …”
Publicado 2020
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4517por Ramanauskaite, Ausra, Schwarz, Frank, Sader, Robert, Becker, Jürgen, Obreja, Karina“…The horizontal mucosal thickness (hMT) and bone thickness (hBT) were measured at four reference points: (v0) at the level of implant shoulder (IS), (v1) 50% of the distance IS-bone crest (BC), (v2) at the BC, and (v3) at the most coronal extension of the bone-to-implant contact. …”
Publicado 2021
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4518por Kimura, Shunsuke, Sekiguchi, Masahiro, Watanabe, Kentaro, Hiwatarai, Mitsuteru, Seki, Masafumi, Yoshida, Kenichi, Isobe, Tomoya, Shiozawa, Yusuke, Suzuki, Hiromichi, Hoshino, Noriko, Hayashi, Yasuhide, Oka, Akira, Miyano, Satoru, Ogawa, Seishi, Takita, Junko“…Neuroblastoma, the most common extracranial solid malignancy among children, originates from undifferentiated neural crest cells (NCC). Despite recent intensified treatment, high-risk patients still have a high mortality rate. …”
Publicado 2021
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4519“…CONCLUSIONS: Inhibiting fatty acid oxidation can specifically reduce the level of H3K27ac in the reproductive crest, which may be the cause of the down-regulation of male differentiation-specific gene expression, which ultimately leads to the male primordial germ cells exited from mitotic arrest. …”
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4520“…BACKGROUND: The gold standard in the treatment of scaphoid pseudarthrosis is reduction, interposition of an iliac crest graft and stabilization with a headless bone (Herbert) screw, aiming to reduce the frequently observed humpback deformity. …”
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