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201“…RESULTS: According to the variable importance obtained from the modeling, ADH1C, DEFA5, CPS1, SPP1, DMBT1, VCAN-AS1, APOB genes (cancer vs. adenoma); LOC399753, APOA4, MIR548X, and ADH1C genes (adenoma vs. adenoma); SNORD123, CEACAM6, SNORD78, ANXA10, SPINK1, and CPS1 (normal vs. adenoma) genes can be used as predictive biomarkers. …”
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202por Taudien, Stefan, Szafranski, Karol, Felder, Marius, Groth, Marco, Huse, Klaus, Raffaelli, Francesca, Petzold, Andreas, Zhang, Xinmin, Rosenstiel, Philip, Hampe, Jochen, Schreiber, Stefan, Platzer, Matthias“…RESULTS: As a proof of principle, we enriched a ~850 kb section comprising the CNV defensin gene cluster DEFB, the invariable DEFA part and 11 control regions from two genomes by sequence capture and sequenced it by 454 technology. 6,651 differences to the human reference genome were found. …”
Publicado 2011
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203por Granlund, Atle Vand Beelen, Beisvag, Vidar, Torp, Sverre H, Flatberg, Arnar, Kleveland, Per Martin, Østvik, Ann Elisabeth, Waldum, Helge L, Sandvik, Arne K“…Tissue samples from IBD and pseudomembranous colitis were examined with routine histology and immunohistochemical analysis for REGIα, REGIV, DEFA6, and serotonin. RESULTS: REG mRNAs were up to 83 times overexpressed in diseased mucosa compared with mucosa from healthy individuals. …”
Publicado 2011
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204por Zhou, Qian, Ding, Wenchao, Jiang, Longyan, Xin, Jiaojiao, Wu, Tianzhou, Shi, Dongyan, Jiang, Jing, Cao, Hongcui, Li, Lanjuan, Li, Jun“…The quantitative real-time polymerase chain reaction (qRT-PCR) validation of the top six genes (CYP19A1, SEMA6B, INHBA, DEFT1P, AZU1 and DEFA4) was consistent with the results of messenger ribonucleic acid (mRNA) sequencing. …”
Publicado 2016
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205por Soler, Alexandra, Cayrefourcq, Laure, Mazard, Thibault, Babayan, Anna, Lamy, Pierre-Jean, Assou, Said, Assenat, Eric, Pantel, Klaus, Alix-Panabières, Catherine“…Moreover, they showed changes in mRNA and protein expression (e.g., DEFA6, ABCB1 and GAL), whereas analysis of chromosomal copy number aberrations revealed no significant variation over time. …”
Publicado 2018
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206por Gardiner, Erin J., Cairns, Murray J., Liu, Bing, Beveridge, Natalie J., Carr, Vaughan, Kelly, Brian, Scott, Rodney J., Tooney, Paul A.“…The differential expression of 6 genes, EIF2C2 (Ago 2), MEF2D, EVL, PI3, S100A12 and DEFA4 was confirmed by QPCR. Genome-wide expression analysis of PBMCs from individuals with schizophrenia was characterized by the alteration of genes with immune system function, supporting the hypothesis that the disorder has a significant immunological component in its etiology.…”
Publicado 2013
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207por Hemmat, Nima, Derakhshani, Afshin, Bannazadeh Baghi, Hossein, Silvestris, Nicola, Baradaran, Behzad, De Summa, Simona“…ELANE, ORM2, RETN, BPI, ARG1, DEFA4, CXCL1, and CAMP were the most important genes involved in this disease according to GEO2R analysis as well. …”
Publicado 2020
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208“…In the present study, we introduced a CRES-T construct derived from the B class gene of Tricyrtis sp. (TrihDEFa-SRDX) into Lilium sp. in order to examine the effect of suppressing B function on the floral organ identity. …”
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209por Ren, Yi, Labinsky, Hannah, Palmowski, Andriko, Bäcker, Henrik, Müller, Michael, Kienzle, Arne“…Two specific modules of interest and eight hub genes (ARG1, DEFA4, HP, MMP8, MMP9, MPO, OLFM4, and PGLYRP1) were screened out. …”
Publicado 2022
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210“…The combination model of DEFA4, CTSG, RETN, CEACAM8, TOP2A, LTF, MPO, ELANE, BIRC5, and LCN2 had a certain diagnostic accuracy in detecting renal involvement with high disease activity in SLE patients. …”
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211por Canale, Vinicius, Spalinger, Marianne R., Alvarez, Rocio, Sayoc-Becerra, Anica, Sanati, Golshid, Manz, Salomon, Chatterjee, Pritha, Santos, Alina N., Lei, Hillmin, Jahng, Sharon, Chu, Timothy, Shawki, Ali, Hanson, Elaine, Eckmann, Lars, Ouellette, André J., McCole, Declan F.“…RESULTS: Partial transcriptome analysis showed that expression of Paneth cell–associated antimicrobial peptides Lyz1, Pla2g2a, and Defa6 was down-regulated markedly in Ptpn2-KO mice compared with wild-type and heterozygous. …”
Publicado 2023
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212por Bouzid, Amal, Almidani, Abdulrahman, Zubrikhina, Maria, Kamzanova, Altyngul, Ilce, Burcu Yener, Zholdassova, Manzura, Yusuf, Ayesha M., Bhamidimarri, Poorna Manasa, AlHaj, Hamid A., Kustubayeva, Almira, Bernstein, Alexander, Burnaev, Evgeny, Sharaev, Maxim, Hamoudi, Rifat“…The integrative analysis between the bioinformatics and ML approaches identified ten key MDD-related biomarkers including NRG1, CEACAM8, CLEC12B, DEFA4, HP, LCN2, OLFM4, SERPING1, TCN1 and THBS1. …”
Publicado 2023
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213por Heung, Macy M. S., Jin, Shengnan, Tsui, Nancy B. Y., Ding, Chunming, Leung, Tak Y., Lau, Tze K., Chiu, Rossa W. K., Lo, Y. M. Dennis“…Microarray analysis revealed upregulation of genes involved in neutrophil functions in pregnant whole blood including DEFA4, CEACAM8, OLFM4, ORM1, MMP8 and MPO. Though possibly pregnancy-related, they were not pregnancy-specific as suggested by the lack of post-delivery reduction in concentrations. …”
Publicado 2009
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214“…An equine intestinal α-defensin (DEFA1), the first characterised in the Laurasiatheria, shows a broad antimicrobial spectrum against human and equine pathogens. …”
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215por Berisha, Stela Z., Serre, David, Schauer, Philip, Kashyap, Sangeeta R., Smith, Jonathan D.“…Among the significantly regulated genes were GGT1, CAMP, DEFA1, LCN2, TP53, PDSS1, OLR1, CNTNAP5, DHCR24, HHAT and SARDH, which have been previously implicated in lipid metabolism, obesity and/or type 2 diabetes. …”
Publicado 2011
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216por Wang, Ji-Lin, Lin, Yan-Wei, Chen, Hui-Min, Kong, Xuan, Xiong, Hua, Shen, Nan, Hong, Jie, Fang, Jing-Yuan“…Microarray gene expression analysis showed that S100a9, Defa20, Mmp10, Mmp7, Ptgs2, and Ang2 were among the most downregulated genes, whereas Per3, Tef, Rnf152, and Prdx6 were significantly upregulated in the DMH + Calcium group compared with the DMH group. …”
Publicado 2011
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217por Yang, Ivana V., Luna, Leah G., Cotter, Jennifer, Talbert, Janet, Leach, Sonia M., Kidd, Raven, Turner, Julia, Kummer, Nathan, Kervitsky, Dolly, Brown, Kevin K., Boon, Kathy, Schwarz, Marvin I., Schwartz, David A., Steele, Mark P.“…These include CAMP, CEACAM6, CTSG, DEFA3 and A4, OLFM4, HLTF, PACSIN1, GABBR1, IGHM, and 3 unknown genes. …”
Publicado 2012
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218por El Shamieh, Said, Ndiaye, Ndeye Coumba, Stathopoulou, Maria G., Murray, Helena A., Masson, Christine, Lamont, John V., Fitzgerald, Peter, Benetos, Athanase, Visvikis-Siest, Sophie“…Confirming this hypothesis, further transcriptomic analyses showed that increased NAMPT mRNA levels were positively correlated with ICAM1, SELL, FPR1, DEFA1-3, and LL-37 genes expression (P≤5×10(−3)). …”
Publicado 2012
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219por Koczulla, A-Rembert, Jonigk, Danny, Wolf, Thomas, Herr, Christian, Noeske, Sarah, Klepetko, Walter, Vogelmeier, Claus, von Neuhoff, Nils, Rische, Johanna, Wrenger, Sabine, Golpon, Heiko, Voswinckel, Robert, Luisetti, Maurizio, Ferrarotti, Ilaria, Welte, Tobias, Janciauskiene, Sabina“…Furthermore, higher expression of KLF9, SNAI1 and DEFA1 was found in ZZ COPD lungs without augmentation therapy relative to MM COPD or ZZ COPD with augmentation therapy. …”
Publicado 2012
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220por Klich, Amna, Mercier, Catherine, Gerfault, Laurent, Grangeat, Pierre, Beaulieu, Corinne, Degout-Charmette, Elodie, Fortin, Tanguy, Mahé, Pierre, Giovannelli, Jean-François, Charrier, Jean-Philippe, Giremus, Audrey, Maucort-Boulch, Delphine, Roy, Pascal“…The extended method allowed estimating the variances explained by the dilution and the technical process by each algorithm in an experiment with 9 proteins: L-FABP, 14.3.3 sigma, Calgi, Def.A6, Villin, Calmo, I-FABP, Peroxi-5, and S100A14. …”
Publicado 2018
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