Mostrando 1 - 20 Resultados de 265 Para Buscar '"DEFA"', tiempo de consulta: 0.13s Limitar resultados
  1. 1
    “…A genetic association study found that increased copy number of the HNP-encoding gene DEFA1/DEFA3 is a risk factor for organ dysfunction during sepsis development. …”
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    Increased gene copy number of DEFA1/DEFA3 worsens sepsis by inducing endothelial pyroptosis
  2. 2
    “…CONCLUSION: PPBP and DEFA1/DEFA3 could be potential CHD biomarkers in Thai hyperlipidaemia patients.…”
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    PPBP and DEFA1/DEFA3 genes in hyperlipidaemia as feasible synergistic inflammatory biomarkers for coronary heart disease
  3. 3
    “…DEFA1/DEFA3, genes encoding human neutrophil peptides (HNP) 1–3, display wide-ranging copy number variations (CNVs) and is functionally associated with innate immunity and infections. …”
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    Low-Copy Number Polymorphism in DEFA1/DEFA3 Is Associated with Susceptibility to Hospital-Acquired Infections in Critically Ill Patients
  4. 4
    Publicado 2022
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    Correction to Supporting Information for Chen et al., Increased gene copy number of DEFA1/DEFA3 worsens sepsis by inducing endothelial pyroptosis
  5. 5
    “…Paneth cell dysfunction has been suggested to be involved in the pathogenesis of NEC. Defensin alpha-6 (DEFA6) is a specific marker for Paneth cells acting as part of the innate immunity in the human intestines. …”
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    Diminished DEFA6 Expression in Paneth Cells Is Associated with Necrotizing Enterocolitis
  6. 6
    “…There was no significant difference in the CN of the DEFA1 gene between BD patients and HC. A high DEFA1 gene CN was significantly associated with intestinal involvement in BD patients. …”
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    Correlation of DEFA1 Gene Copy Number Variation with Intestinal Involvement in Behcet's Disease
  7. 7
    “…However, the roles of α‐Defensin 5 (DEFA5) in tumorigenesis and development remain unknown. …”
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    The inhibitory effect of human DEFA5 in growth of gastric cancer by targeting BMI1
  8. 8
    “…Previous studies suggest that Paneth cells are involved in NEC development. Defensin alpha 6 (DEFA6) and guanylate cyclase activator 2A (GUCA2A) are selective protein markers of Paneth cells. …”
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    Paneth cell proteins DEFA6 and GUCA2A as tissue markers in necrotizing enterocolitis
  9. 9
    “…The α-defensin cluster on human chromosome 8p23.1 is one of the better-characterized CNVs, in which high copy number variability affecting the DEFA1 and DEFA3 genes has been reported. Moreover, the DEFA3 gene has been found to be absent in a significant proportion of control population subjects. …”
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    Inter-population variability of DEFA3 gene absence: correlation with haplotype structure and population variability
  10. 10
    “…Our results have allowed us to discover that the SNP rs4300027 is strongly associated with DEFA1A3 gene copy number in European samples. CONCLUSIONS: We have developed an accurate and robust method for measurement of DEFA1A3 copy number. …”
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    Accurate measurement of gene copy number for human alpha-defensin DEFA1A3
  11. 11
    “…We assessed DNA methylation in five NEC-associated genes, selected from literature: EPO, VEGFA, ENOS, DEFA5, and TLR4 in infants with NEC and controls. …”
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    DNA Methylation of TLR4, VEGFA, and DEFA5 Is Associated With Necrotizing Enterocolitis in Preterm Infants
  12. 12
    “…DEFA1A3 encodes human neutrophil peptides (HNPs) 1–3 and has multiple copy number variations (CNVs). …”
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    Increased Gene Copy Number of DEFA1A3 Is Associated With the Severity of Ulcerative Colitis
  13. 13
    “…Defensin Alpha 4 (DEFA4) is the fourth member of the Alpha Defensins family known as a part of antimicrobial peptides in the innate immune system. …”
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    Alterations in Immune-Related Defensin Alpha 4 (DEFA4) Gene Expression in Health and Disease
  14. 14
    “…Additionally, the proteins encoded by DEFA 1/3 and DEFA 4 were visualized in paraffin-embedded tissue sections by immunohistochemical staining. …”
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    Human α-defensin (DEFA) gene expression helps to characterise benign and malignant salivary gland tumours
  15. 15
    “…METHODS: Small intestine and enteroids from Defa4(Cre);Rosa26 tandem dimer Tomato (tdTomato), a red fluoresent protein, (or Rosa26 Enhanced Yellow Fluorescent Protein (EYFP)) reporter, Notch gain-of-function (Defa4(Cre);Rosa26 Notch Intracellular Domain (NICD)-ires-nuclear Green Fluorescent Protein (nGFP) and Defa4(Cre);Rosa26(reverse tetracycline transactivator–ires) Enhanced Green Fluorescent Protein (EGFP);TetO(NICD)), A Disintegrin and Metalloproteinase domain-containing protein 10 (ADAM10) loss-of-function (Defa4(Cre);ADAM10(flox/flox)), and Adenomatous polyposis coli (APC) inactivation (Defa4(Cre);APC(flox/flox)) mice were analyzed. …”
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    Cellular Plasticity of Defa4(Cre)-Expressing Paneth Cells in Response to Notch Activation and Intestinal Injury
  16. 16
    “…RESULTS: In this study, a region flanking the DEFA1A3 locus was sequenced across 120 independent haplotypes with European ancestry, identifying five common classes of DEFA1A3 haplotype. …”
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    Inferring mechanisms of copy number change from haplotype structures at the human DEFA1A3 locus
  17. 17
    “…SIGNIFICANCE: Together, our results demonstrated that the anti-ZIKV activity of DEFA1B can be mediated by exosomes, and DEFA1B interacts with ORC1 to retard cell cycles. …”
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    DEFA1B inhibits ZIKV replication and retards cell cycle progression through interaction with ORC1
  18. 18
    “…For PJI, we detected elevated mRNA expression levels of DEFA1 (P < 0.0001), IL1B (P < 0.0001), LTF (P < 0.0001), TLR1 (P = 0.02), and BPI (P = 0.01) in comparison to those in tissues from aseptic cases. …”
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    Excellent Diagnostic Characteristics for Ultrafast Gene Profiling of DEFA1-IL1B-LTF in Detection of Prosthetic Joint Infections
  19. 19
    “…Herein, we report an experimental approach to determine with precision and specificity expression levels of α-defensin (Defa) mRNA in the small intestine of C57BL/6 mice through an optimized set of oligonucleotide primers for qRT-PCR assays and cloned cDNA plasmids corresponding to the Defa paralogs. …”
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    An Experimental Approach to Rigorously Assess Paneth Cell α-Defensin (Defa) mRNA Expression in C57BL/6 Mice
  20. 20
    “…METHODS: By using quantitative Real Time-PCR, the gene expression pattern of DEFA 1-3 and DEFA 6 was analyzed in tissue of different stages of carcinogenesis, derived from colorectal cancer patients. …”
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    Defensin alpha 6 (DEFA 6) overexpression threshold of over 60 fold can distinguish between adenoma and fully blown colon carcinoma in individual patients
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