“…Molecular validation showed that expression of FGF9 was upregulated by the DJ-1/Wnt signaling pathway and decreasing FGF9-expression impeded DJ-1-induced CRC invasive ability and EMT, suggesting that FGF9 is involved in DJ-1-enhanced CRC metastasis. …”
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“…Small molecule RNAs (microRNAs) are a kind of endogenous, stable, and noncoding RNA molecule that can regulate the expression of target genes such as DJ-1 at the posttranscriptional level. This study aimed to detect the expression of salivary microRNAs and to discover their value as a salivary potential biomarker for Parkinson’s disease (PD). …”
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“…In DJ-1 knock-out (DJ-1(-/-)) mice the production of fecal calprotectin and MCP-1 inflammatory proteins were elevated. …”
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“…Intravascular migration of DJ stent is a rare complication that needs immediate attention to prevent severe complication. …”
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“…And silencing of DJ-1 in rats or alveolar epithelial cells blocked the protection effect of TP. …”
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“…Serial serum levels of DJ1, L1CAM, CA125 and HE4 were collected in 65 enrolled patients. …”
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“…CONCLUSIONS: The above results indicated that trehalose metabolism promotes DJ3 formation and helps DJ3 survive at -20 °C. Although trehalose accumulation is favorable for DJ3 to cope with low-temperature stress, multiple trehalose metabolism genes need to work together. …”
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“…Using genetically modified mice (DJ1-KO, Nrf2-KO, STING(gt/gt) and STING-KO) and immunolabeling technique, we identified that WA targeted DJ1-Nrf2-STING pathway in dopaminergic neurons; and we demonstrate that STING might be an important factor in PD pathogenesis. …”
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“…Data analysis showed a significant (P<0.05) increase (1.5-fold) in the expression level of DJ-1 in peel groups than in control. CONCLUSION: The expression of antioxidant genes and DJ-1 protein in ram testes are more influenced by pomegranate peel than seed.…”
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“…Upon addition of DJ-1, this NMR signature of glyc-ac-αSyn monomers reverts to a native ac-αSyn-like character. …”
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“…No significant differences were observed in operative time (MD: 2.26; 95% CI −9.62 to 14.14; P = 0.79), operative success rate (OR: 1.10; 95% CI 0.57 to 2.10; P = 0.780), length of hospital stay (MD: 0.65; 95% CI −0.04 to 1.34; P = 0.063), or complications (OR: 0.87; 95%CI 0.48 to 1.56; P = 0.630) between external stents and DJ stents in pediatric pyeloplasty. According to the subgroup analysis, we found the external stent group had a shorter operative time than the DJ stent group in terms of robot-assisted laparoscopic pyeloplasty (MD: −17.13; 95% CI −32.8 to −1.45; P = 0.032). …”
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“…Most strikingly, activation of STAT3 by TrkC-mediated inhibition of DJ-1 degradation significantly enhances the efficacy of invasion and metastasis during the progression of HCC cells. …”
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“…Based on gene content similarity, Vardy is assigned to cluster DJ.…”
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“…Conclusion This study documented trends in expression patterns of three important signaling molecules, DJ-1, PTEN, and p-Akt, in normal, premalignant, and malignant oral keratinocytes. …”
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“…DJ-1 superfamily proteins, including the human DJ-1, a genetic determinant of Parkinson’s disease, possess diverse physiological functions paramount for combating multiple stressors. …”
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“…BACKGROUND: DJ‐1 is a causative gene for Parkinson's disease. …”
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“…We then investigated changes in the distribution of DJ-1 in astrocytes, DJ-1 release from cultured astrocytes, and the effects of recombinant DJ-1 protein on hydrogen peroxide (H(2)O(2))-induced death in normal and DJ-1-knockdown SH-SY5Y cells and on in vitro scavenging of hydroxyl radicals ((•)OH) by electron spin resonance spectrometry. …”
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“…METHODOLOGY/PRINCIPAL FINDINGS: Using DJ-1 loss of function cellular models from knockout (KO) mice and human carriers of the E64D mutation in the DJ-1 gene we define a novel role of DJ-1 in the integrity of both cellular organelles, mitochondria and lysosomes. …”
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“…Furthermore, in vitro results showed that silencing DJ-1 increased the proliferation inhibitory effect of cisplatin to A549/DDP cells. …”
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