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41“…BACKGROUND: DJ-1 is a key regulator in human tumorigenesis, including brain malignancies. …”
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42por Hauser, David N., Mamais, Adamantios, Conti, Melissa M., Primiani, Christopher T., Kumaran, Ravindran, Dillman, Allissa A., Langston, Rebekah G., Beilina, Alexandra, Garcia, Joseph H., Diaz-Ruiz, Alberto, Bernier, Michel, Fiesel, Fabienne C., Hou, Xu, Springer, Wolfdieter, Li, Yan, de Cabo, Rafael, Cookson, Mark R.“…BACKGROUND: Early onset Parkinson’s disease is caused by variants in PINK1, parkin, and DJ-1. PINK1 and parkin operate in pathways that preserve mitochondrial integrity, but the function of DJ-1 and how it relates to PINK1 and parkin is poorly understood. …”
Publicado 2017
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43“…Mutations in the protein DJ-1 cause autosomal recessive forms of Parkinson’s disease (PD) and oxidized DJ-1 is found in the brains of idiopathic PD individuals. …”
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44por Shimizu, Yuuki, Nicholson, Chad K., Polavarapu, Rohini, Pantner, Yvanna, Husain, Ahsan, Naqvi, Nawazish, Chin, Lih‐Shen, Li, Lian, Calvert, John W.“…BACKGROUND: DJ‐1 is a ubiquitously expressed protein typically associated with the development of early onset Parkinson disease. …”
Publicado 2020
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45por Nakamura, Koutarou, Sakai, Seiichiro, Tsuyama, Jun, Nakamura, Akari, Otani, Kento, Kurabayashi, Kumiko, Yogiashi, Yoshiko, Masai, Hisao, Shichita, Takashi“…Our results demonstrate a previously unknown function of DJ-1 as a DAMP and suggest that extracellular DJ-1 could be a therapeutic target to prevent inflammation in tissue injuries and neurodegenerative diseases.…”
Publicado 2021
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46“…Herein, we investigated the effect of DJ-1 on helper T cell differentiation, fibroblast-like synoviocyte (FLS) activation, and osteoclastogenesis in rheumatoid arthritis (RA). …”
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47por Bhattacharyya, Sanghamitra, Sturgis, Johnathon, Maminishkis, Arvydas, Miller, Sheldon S., Bonilha, Vera L.“…Monolayers of the ARPE-19 cell line and primary human fetal RPE (hfRPE) cultures were infected with replication-deficient adenoviruses to investigate the effects of increased levels of DJ-1 in these monolayers. Adenoviruses carried the full-length human DJ-1 cDNA (hDJ) and mutant constructs of DJ-1, which had all or each of its three C residues individually mutated to serine (S). …”
Publicado 2022
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48por Xu, Lingling, Wu, Jie, Li, Nini, Jiang, Chengjun, Guo, Yan, Cao, Peng, Wang, Dianlei“…The present study describes a novel mechanism by which AITC induces MRP1 expression by protecting against CS/CSE-mediated DJ-1 protein degradation via activation of the DJ-1/Nrf2 axis.…”
Publicado 2020
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49“…Our studies also provide evidence that DJ-1 is allosterically activated by glutathione. …”
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50por Tsoporis, James N., Amatullah, Hajera, Gupta, Sahil, Izhar, Shehla, Ektesabi, Amin M., Vaswani, Chirag M., Desjardins, Jean-Francois, Kabir, Golam, Teixera Monteiro, Ana Paula, Varkouhi, Amir K., Kavantzas, Nikolaos, Salpeas, Vasileios, Rizos, Ioannis, Marshall, John C., Parker, Thomas G., Leong-Poi, Howard, dos Santos, Claudia C.“…Oxidative stress is considered one of the early underlying contributors of sepsis-induced myocardial depression. DJ-1, also known as PARK7, has a well-established role as an antioxidant. …”
Publicado 2023
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51por Ishikawa, Shizuma, Taira, Takahiro, Takahashi-Niki, Kazuko, Niki, Takeshi, Ariga, Hiroyoshi, Iguchi-Ariga, Sanae M. M.“…Loss-of-function mutation in the DJ-1 gene causes a subset of familial Parkinson disease. …”
Publicado 2010
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52por Miyama, Akiko, Saito, Yoshiro, Yamanaka, Kazunori, Hayashi, Kojiro, Hamakubo, Takao, Noguchi, Noriko“…In the present study, mechanisms of DJ-1 oxidation induced by 6-hydroxydopamine (6-OHDA) were investigated by using SH-SY5Y cells. …”
Publicado 2011
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53por Lin, Xiangmin, Cook, Travis J., Zabetian, Cyrus P., Leverenz, James B., Peskind, Elaine R., Hu, Shu-Ching, Cain, Kevin C., Pan, Catherine, Edgar, John Scott, Goodlett, David R., Racette, Brad A., Checkoway, Harvey, Montine, Thomas J., Shi, Min, Zhang, Jing“…DJ-1 is a multifunctional protein that plays an important role in oxidative stress, cell death, and synucleinopathies, including Parkinson disease. …”
Publicado 2012
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54“…AIM: The research investigates the expression of MIB-1 and DJ-1 in different grades of astrocytomas and evaluates the possible prognostic role of DJ-1 in these tumors in relation to other prognostic parameters including the MIB-1 labeling index. …”
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55“…Recent studies show that exosome isolated from urine contains LRRK2 or DJ-1, proteins whose mutations cause PD. To investigate a potential use for urine exosomes as a tool for PD diagnosis, we compared levels of LRRK2, α-synuclein, and DJ-1 in urine exosomes isolated from Korean PD patients and non-PD controls. …”
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56por Guzman, Jaime N., Sanchez-Padilla, Javier, Wokosin, David, Kondapalli, Jyothisri, Ilijic, Ema, Schumacker, Paul T., Surmeier, D. James“…The mild uncoupling was not affected by deletion of cyclophilin D, a component of the permeability transition pore, but was attenuated by genipin and purine nucleotides, antagonists of cloned uncoupling proteins. Knocking out DJ-1, a gene associated with an early onset form of PD, down-regulated the expression of two uncoupling proteins (UCP4, 5), compromised calcium-induced uncoupling and increased oxidation of matrix proteins specifically in SNc dopaminergic neurons. …”
Publicado 2010
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57“…BACKGROUND: DJ-1 has been thought as a candidate biomarker for Parkinson’s disease (PD). …”
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58por Kim, Do-Kyun, Beaven, Michael A., Kulinski, Joseph M., Desai, Avanti, Bandara, Geethani, Bai, Yun, Prussin, Calman, Schwartz, Lawrence B., Komarow, Hirsh, Metcalfe, Dean D., Olivera, Ana“…Our findings provide evidence of increased ROS and a biphasic regulation of the antioxidant DJ-1 in variants of SM and implicate IL-6 in DJ-1 induction and expansion of mast cells with KIT mutations. …”
Publicado 2016
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59por Kim, Hyuk Soon, Nam, Seung Taek, Mun, Se Hwan, Lee, Sun-Kyeong, Kim, Hyun Woo, Park, Young Hwan, Kim, Bokyung, Won, Kyung-Jong, Kim, Hae-Rim, Park, Yeong-Min, Kim, Hyung Sik, Beaven, Michael A., Kim, Young Mi, Choi, Wahn Soo“…DJ-1 ablation in mice leads to a decreased bone volume and an increase in OC numbers. …”
Publicado 2017
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60por Strobbe, Daniela, Robinson, Alexis A., Harvey, Kirsten, Rossi, Lara, Ferraina, Caterina, de Biase, Valerio, Rodolfo, Carlo, Harvey, Robert J., Campanella, Michelangelo“…The deglycase and chaperone protein DJ-1 is pivotal for cellular oxidative stress responses and mitochondrial quality control. …”
Publicado 2018
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