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  1. 88341
    “…Youth data included day-to-day discrimination (InDI-D), depression, (MDS), psychological distress (Kessler-6), gender distress (TYC-GDS), gender positivity (TYC-GPS), and P/C support (self-report by youth and P/C). …”
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    SUN-LB14 Trans and Non-Binary Youth Accessing Gender Affirming Medical Care in Canada: New Research From the Trans Youth CAN!
  2. 88342
    “…Baseline body weight was positively associated, and fat mass inversely associated with disposition index (Di; islets’ ability to secrete insulin normalized to insulin resistance) at 18 months (p=0.019 for both). …”
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    SUN-621 Body Weight and Body Composition in Patients with Chronic Pancreatitis Are Associated with Islet Function After Total Pancreatectomy and Islet Cell Transplantation
  3. 88343
    “…The editing events encompass single base insertions and di/trinucleotide deletions of Vvi-TAS4a/b and Vvi-MYBA7 at expected positions 3 nt upstream from the guideRNA proximal adjacent motifs NGG. …”
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    CRISPR/Cas9-mediated targeted mutagenesis of TAS4 and MYBA7 loci in grapevine rootstock 101-14
  4. 88344
    “…SNNN models were then applied to four Mexican cohorts (SIGMA-UIEM, n=1521; Metabolic Syndrome cohort, n=6144; ENSANUT 2016, n=614 and CAIPaDi, n=1608) to characterize diabetes subgroups in Mexicans according to treatment response, risk for chronic complications and risk factors for the incidence of each subgroup. …”
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    Clinical characterization of data-driven diabetes subgroups in Mexicans using a reproducible machine learning approach
  5. 88345
    “…The National Centre for Rare Diseases at the Istituto Superiore di Sanità coordinates the whole project. The software PhenoTips was used to collect the information of the clinical cases. …”
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    Improving diagnosis for rare diseases: the experience of the Italian undiagnosed Rare diseases network
  6. 88346
    por Núñez-Gil, Iván J., Fernández-Pérez, Cristina, Estrada, Vicente, Becerra-Muñoz, Víctor M., El-Battrawy, Ibrahim, Uribarri, Aitor, Fernández-Rozas, Inmaculada, Feltes, Gisela, Viana-Llamas, María C., Trabattoni, Daniela, López-País, Javier, Pepe, Martino, Romero, Rodolfo, Castro-Mejía, Alex F., Cerrato, Enrico, Astrua, Thamar Capel, D’Ascenzo, Fabrizio, Fabregat-Andres, Oscar, Moreu, José, Guerra, Federico, Signes-Costa, Jaime, Marín, Francisco, Buosenso, Danilo, Bardají, Alfredo, Raposeiras-Roubín, Sergio, Elola, Javier, Molino, Ángel, Gómez-Doblas, Juan J., Abumayyaleh, Mohammad, Aparisi, Álvaro, Molina, María, Guerri, Asunción, Arroyo-Espliguero, Ramón, Assanelli, Emilio, Mapelli, Massimo, García-Acuña, José M., Brindicci, Gaetano, Manzone, Edoardo, Ortega-Armas, María E., Bianco, Matteo, Trung, Chinh Pham, Núñez, María José, Castellanos-Lluch, Carmen, García-Vázquez, Elisa, Cabello-Clotet, Noemí, Jamhour-Chelh, Karim, Tellez, María J., Fernández-Ortiz, Antonio, Macaya, Carlos
    Publicado 2020
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    Mortality risk assessment in Spain and Italy, insights of the HOPE COVID-19 registry
  7. 88347
    “…Conversely, in CaCl(2)-induced AAA, K4/K9/K27/K36/K79 monomethylation and K9/K18/K56 acetylation were reduced in AAA tissues, whereas K27 di-/tri-methylation and K14 acetylation were upregulated. …”
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    Profiling of Histone Modifications Reveals Epigenomic Dynamics During Abdominal Aortic Aneurysm Formation in Mouse Models
  8. 88348
    “…JQ1 treatment resulted in increased mono- and di-methylation of H3.1K27, H3.3K27, H3.3K36 and H4K20 in vitro. …”
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    Histone tail analysis reveals H3K36me2 and H4K16ac as epigenetic signatures of diffuse intrinsic pontine glioma
  9. 88349
    “…Methods: The mRNA expression of DiGeorge syndrome critical region gene 8 (DGCR8), has-miR-106a, and Runt-related transcription factor 3 (RUNX3) was examined by quantitative real-time PCR (RT-qPCR). …”
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    DGCR8/miR-106 Axis Enhances Radiosensitivity of Head and Neck Squamous Cell Carcinomas by Downregulating RUNX3
  10. 88350
    “…Clinical studies have proven that combinations of FDA-approved Bcl-2 inhibitor, venetoclax and hypomethylating agents (HMA) are highly effective in elderly patients with AML (DiNardo et al., 2019). Adhesion to the BM niche is critical for AML initiation, progression and LSC survival after induction therapy. …”
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    AML-337: Targeting E-Selectin with GMI-1271 Overcomes Microenvironment-Mediated Resistance to Venetoclax/HMA Therapy
  11. 88351
    “…RESULTS: Histone 3 lysine 4 di- and trimethylation (H3K4me2, H3K4me3) and lysine 27 trimethylation (H3K27me3) mark expression was evaluated in 241 acute myeloid leukemia (AML), 114 B-cell acute lymphoblastic leukemia (B-ALL) and 14T-cell ALL (T-ALL) patient samples at time of diagnosis using reverse phase protein array. …”
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    Loss of H3K27 methylation identifies poor outcomes in adult-onset acute leukemia
  12. 88352
    “…METHODS: This was a retrospective analysis of the CoDiC® database of the Japan Diabetes Clinical Data Management Study Group (JDDM). …”
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    Glucagon-Like Peptide-1 Receptor Agonist Utilization in Type 2 Diabetes in Japan: A Retrospective Database Analysis (JDDM 57)
  13. 88353
    “…Secondary outcomes will include the incremental cost per reducing 1 case of relapse; patient reported intolerance to the treatment; adverse events; change of mean disease activity measured by DAS28, clinical disease activity index (CDAI) and simplified disease activity index (SDAI); the proportion of modified Sharp score increase < 0.3; ultrasound-detected remission in hands; Health Assessment Questionnaire Disability Index (HAQ-DI) and health related quality of life [the five-level EuroQol-5D (EQ-5D-5L) and short form-6D (SF-6D)]. …”
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    The efficacy, safety and cost-effectiveness of hydroxychloroquine, sulfasalazine, methotrexate triple therapy in preventing relapse among patients with rheumatoid arthritis achieving clinical remission or low disease activity: the study protocol of a randomized controlled clinical Trial (ESCoRT study)
  14. 88354
    “…These pathways were also investigated for type 1 diabetes-associated RNA expression profiles using laser-dissected islets from two to five tissue sections per donor from the Diabetes Virus Detection (DiViD) study and the network of Pancreatic Organ Donors (nPOD). …”
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    Genetic predisposition in the 2′-5′A pathway in the development of type 1 diabetes: potential contribution to dysregulation of innate antiviral immunity
  15. 88355
    “…The primary outcome will be the rate of treatment success according to the American College of Rheumatology 20 (ACR20), and the co-primary outcome will be the Health Assessment Questionnaire—Disability Index (HAQ-DI). Conclusions will be based on equivalence hypothesis testing using predefined margins of equivalence elicited from a group of experienced rheumatologists and prior studies. …”
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    Equivalence and switching between biosimilars and reference molecules in rheumatoid arthritis: protocol for a systematic review and meta-analysis
  16. 88356
    “…BACKGROUND: TBX1 (T-box transcription factor 1) is a major candidate gene that likely contributes to the etiology of velo-cardio-facial syndrome/DiGeorge syndrome (VCFS/DGS). Although the haploinsufficiency of TBX1 in both mice and humans results in congenital cardiac malformations, little has been elucidated about its upstream regulation. …”
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    Variants in a cis-regulatory element of TBX1 in conotruncal heart defect patients impair GATA6-mediated transactivation
  17. 88357
    “…The oral hygiene of all the children was estimated through Oral Hygiene Index-Simplified Debris (DI-S) score at day 1 and after 3 months after intervention. …”
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    Comparison between Conventional, Game-based, and Self-made Storybook-based Oral Health Education on Children's Oral Hygiene Status: A Prospective Cohort Study
  18. 88358
    “…RESULTS: Herein, a water-soluble biodegradable nitroxides-based mCA (Linear pDHPMA-mPEG-Ppa-PROXYL) was prepared via covalent conjugation of a nitroxides (2,2,5,5-tetramethyl-1-pyrrolidinyl-N-oxyl, PROXYL) onto an enzyme-sensitive linear di-block poly[N-(1, 3-dihydroxypropyl) methacrylamide] (pDHPMA). …”
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    A nitroxides-based macromolecular MRI contrast agent with an extraordinary longitudinal relaxivity for tumor imaging via clinical T1WI SE sequence
  19. 88359
    “…In both cultivars, the CP soil significantly decreased the height increment (HI), basal diameter increment (DI), dry matter accumulation (DMA), net photosynthetic rate (Pn), total chlorophyll content (TChl), carotenoid content (Caro) and photosynthetic nitrogen use efficiency (PNUE). …”
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    Drought stress introduces growth, physiological traits and ecological stoichiometry changes in two contrasting Cunninghamia lanceolata cultivars planted in continuous-plantation soils
  20. 88360
    “…We report here the synthesis, purification, and characterization of mono- and di-fatty acyl conjugates of remdesivir (RDV) and their in vitro antiviral activity against SAR-CoV-2, an Ebola virus transcription- and replication-competent virus-like particle (trVLP) system, and infectious Ebola virus. …”
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    Synthesis and antiviral activity of fatty acyl conjugates of remdesivir against severe acute respiratory syndrome coronavirus 2 and Ebola virus
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