“…The crystal structure of two multi-component crystals of ciprofloxacin [systematic name: 1-cyclo­propyl-6-fluoro-4-oxo-7-(piperazin-1-yl)quinoline-3-carb­­oxy­lic acid], a fluoro­quinolone anti­biotic, namely, ciprofloxacin 2,6-di­hydroxy­benzoate salt, C(17)H(19)FN(3)O(3) (+)·C(7)H(5)O(4) (−), (I), and ciprofloxacin hydro­chloride–3,5-di­hydroxy­benzoic–water (1/1/1), C(17)H(19)FN(3)O(3) (+)·Cl(−)·C(7)H(6)O(4)·H(2)O, (II), were determined. …”
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“…Nucleotide second messengers are long presumed to be the stimulators of type I interferons, of which bacterial cyclic-di-GMP (c-di-GMP) has been implicated in multiple signaling pathways governing communication with other bacteria and host cells, yet its importance in the context of rickettsial interactions with the host has not been investigated. …”
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“…In this Article, we showcase the power of [5,5]-rearrangement recently developed in our laboratory for constructing an intriguing dearomative sulfonium specie which features versatile and unique reactivities to perform nucleophilic 1,2- and 1,4-addition and cyclization, thus achieving dearomative di- and trifunctionalization of easily accessible aryl sulfoxides. …”
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“…We provide evidence that c-di-GMP also regulates transcription of the alginate operon in P. aeruginosa. …”
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“…The mol­ecular structure of the title compound {systematic name: 1,3-di­cyclo­hexyl-1-[2-(1,3-dioxo-2,3-di­hydro-1H-isoindol-2-yl)acet­yl]urea}, C(23)H(29)N(3)O(4), derived from N,N′-di­cyclo­hexyl­urea, shows that the tertiary N atom substituted by a cyclo­hexyl and phthaloylglycyl groups adopts a perfectly planar geometry (bond-angle sum = 360.0°). …”
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“…Cyclic di-adenosine monophosphate (c-di-AMP) is a second messenger which is widely used in signal transduction in bacteria and archaea. c-di-AMP plays an important role in the regulation of bacterial physiological activities, such as the cell cycle, cell wall stability, environmental stress response, and biofilm formation. …”
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“…Here we show that c-di-GMP also binds the glycogen-debranching-enzyme, GlgX, uncovering a direct link between c-di-GMP and glycogen metabolism in bacteria. …”
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“…[Image: see text] In this work, we demonstrate that the forbidden oxirane-type photoproduct (the cyclopropyl ketone photoproduct is the allowed one) of the oxa-di-π-methane photorearrangement can be obtained by mechanochemical control of the photoreactions. …”
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“…The structure of 4,5-diferrocenyl-1,2-di­thiole-3-thione, [Fe(2)(C(5)H(5))(2)(C(13)H(8)S(3))] or C(23)H(18)Fe(2)S(3), at 130 K has monoclinic (P2(1)/c) symmetry. …”
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“…This compound, denoted di-ᴅ-psicose anhydride (DPA), exhibited a lower water solubility (40 g/L) and higher thermal stability (peak temperature = 194.7 °C) than that of ᴅ-psicose (peak temperature = 126.5 °C). …”
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“…Propylthiouracil is associated with multiple adverse effects such as rash, agranulocytosis hepatitis and antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis, but rarely triggers DRESS/DiHS syndrome. Here, we describe a severe case of propylthiouracil-induced DRESS/DiHS syndrome. …”
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“…In the title compounds, N,N-di­methyl­acetamide–1-(dimethyl-λ(4)-aza­nyl­idene)ethan-1-ol tribromide (1/1), C(4)H(9)NO·C(4)H(10)NO(+)·Br(3) (−) or [(C(4)H(9)NO)·(C(4)H(10)NO)](Br(3)), (I), N,N-di­methyl­acetamide–1-(dimethyl-λ(4)-aza­nyl­idene)ethan-1-ol di­bromido­iodate (1/1), C(4)H(9)NO·C(4)H(10)NO(+)·Br(2)I(−) or [(C(4)H(9)NO)·(C(4)H(10)NO)](Br(2)I), (II), and N,N-di­methyl­acetamide–1-(dimethyl-λ(4)-aza­nyl­idene)ethan-1-ol di­chlorido­iodate (1/1), C(4)H(9)NO·C(4)H(10)NO(+)·Cl(2)I(−) or [(C(4)H(9)NO)·(C(4)H(10)NO)]·(Cl(2)I), (III), all the anions are almost linear in geometry and all the cations, except for the methyl H atoms, are essentially planar. …”
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“…Il compasso geometrico e militare / di Roberto Vergara Caffarelli - Le operazioni del compasso geometrico e militare / Galileo Galilei - Annotazioni / Mattia Bernaggeri - Usus et fabrica circini cuiusdam proportionis / Baldassarre Capra - Difesa contro alle calunnie ed imposture di Baldassar Capra.…”
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