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361“…Using micro-tensile tests to analyse the single-crystalline constituents of the Canyon Diablo meteorite, herein, we show that the taenite matrix exhibits excellent balance between yield strength and ductility superior to that of the kamacite matrix. …”
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362por Tirri, Micaela, Frisoni, Paolo, Bilel, Sabrine, Arfè, Raffaella, Trapella, Claudio, Fantinati, Anna, Corli, Giorgia, Marchetti, Beatrice, De-Giorgio, Fabio, Camuto, Cristian, Mazzarino, Monica, Gaudio, Rosa Maria, Serpelloni, Giovanni, Schifano, Fabrizio, Botrè, Francesco, Marti, Matteo“…Moreover, we investigated the effect of 4,4′-DMAR on the expression of markers of oxidative/nitrosative stress (8-OHdG, iNOS, NT and NOX2), apoptosis (Smac/DIABLO and NF-κB), and heat shock proteins (HSP27, HSP70, HSP90) in the cerebral cortex. …”
Publicado 2021
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363por RiusTabla de Contenidos: “…Prólogo -- Presentación -- Ángeles -- Clérigos -- Cristos -- Diablos -- Evangelización -- Fieles -- Navidad -- Sagradas escrituras.…”
Publicado 2007
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364por Farneti, Brian, Khomenko, Iuliia, Ajelli, Matteo, Wells, Karen Elizabeth, Betta, Emanuela, Aprea, Eugenio, Giongo, Lara, Biasioli, Franco“…In this study the complexity of raspberry aroma was investigated by a comprehensive untargeted VOC analysis, done by combining SPME-GC-MS and PTR-ToF-MS assessments with multi-block discriminant analysis using the DIABLO mixOmics framework. The aim was to acquire an exhaustive characterization of the raspberry volatilome according to different fruit ripening stages (pink, ripe, and overripe) and genetic variances (50 accessions), as well as to investigate the potential of PTR-ToF-MS as a rapid and high throughput VOC phenotyping tool to address issues related to raspberry fruit quality. …”
Publicado 2023
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365por Yu, Xiaoyang, Wang, Tongxing, Li, Yue, Li, Yiquan, Bai, Bing, Fang, Jinbo, Han, Jicheng, Li, Shanzhi, Xiu, Zhiru, Liu, Zirui, Yang, Xia, Li, Yaru, Zhu, Guangze, Jin, Ningyi, Shang, Chao, Li, Xiao, Zhu, Yilong“…RESULTS: This study showed that Apoptin induced a strong and long‐ lasting ER stress and injury, which subsequently led to an imbalance of cellular Ca(2+) levels, a reduction in the mitochondrial membrane potential, a significant extent image in the mitochondrial structure, and an increase in the expression levels of Smac/Diablo and Cyto‐C. CONCLUSIONS: In summary, Apoptin induced apoptosis in HepG‐2 cells via Ca(2+) imbalance and activation of the mitochondrial apoptotic pathway. …”
Publicado 2022
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366por Patterson, LaNisha L., Byerly, Caitlan D., Solomon, Regina, Pittner, Nicholas, Bui, Duc Cuong, Patel, Jignesh, McBride, Jere W.“…Furthermore, treatment with SM-164, a second mitochondrial activator of caspases (Smac/DIABLO) antagonist, resulted in decreased procaspase levels and increased caspase activation, induced apoptosis, and significantly decreased infection. …”
Publicado 2023
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367“…RESULTS: We identified seven genes - ALG5, BRD7, DIABLO, RSU1, SFXN5, STIMATE, TJP3, and VDAC2 - and their corresponding transcript isoforms as potential candidates (false discovery rate ≤0.05). …”
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368“…Experiments utilising a peptide derived from Smac/DIABLO gave no indication that inhibitor of apoptosis proteins might exert an inhibiting effect in primary clear cell RCC. …”
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369por Buron, Nelly, Porceddu, Mathieu, Brabant, Magali, Desgué, Diana, Racoeur, Cindy, Lassalle, Myriam, Péchoux, Christine, Rustin, Pierre, Jacotot, Etienne, Borgne-Sanchez, Annie“…We found that ABT-737 can induce the Bax-dependent release of apoptotic proteins (cytochrome c, Smac/Diablo and Omi/HtrA2 but not AIF) from various but not all cancer cell mitochondria. …”
Publicado 2010
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370“…Fucoidan was also shown to enhance mitochondrial membrane permeability, as well as the cytochrome c and Smac/Diablo release from the mitochondria. Fucoidan increased the levels of the Bak and truncated Bid proteins, but reduced the levels of Mcl-1. …”
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371por Gu, Bin, Zhang, Guo-Feng, Li, Ling-Yun, Zhou, Feng, Feng, Dong-Ju, Ding, Chuan-Lin, Chi, Jing, Zhang, Chun, Guo, Dan-Dan, Wang, Jing-Feng, Zhou, Hong, Yao, Kun, Hu, Wei-Xing“…HHV-6A infection increased the release of Smac/Diablo, AIF and cytochrome c from mitochondria to cytosol, which induced apoptosis via the caspase-dependent and -independent pathways. …”
Publicado 2011
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372por Stanton, Peter G., Sluka, Pavel, Foo, Caroline F H., Stephens, Andrew N., Smith, A. Ian, McLachlan, Robert I., O’Donnell, Liza“…Loss of androgenic stimulus caused changes in proteins with known roles in meiosis (including Nasp and Hsp70–2), apoptosis (including Diablo), cell signalling (including 14-3-3 isoforms), oxidative stress, DNA repair, and RNA processing. …”
Publicado 2012
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373por Long, Jianting, Liu, Liu, Nikolovska-Coleska, Zaneta, Shangary, Sanjeev, Yi, Han, Wang, Shenming, Wang, Shaomeng“…Cytochrome C and Smac/Diablo were tested in both supernatants and mitochondrial pellets by Western blotting. …”
Publicado 2013
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374por Ortiz-Lazareno, Pablo César, Bravo-Cuellar, Alejandro, Lerma-Díaz, José Manuel, Jave-Suárez, Luis Felipe, Aguilar-Lemarroy, Adriana, Domínguez-Rodríguez, Jorge Ramiro, González-Ramella, Oscar, De Célis, Ruth, Gómez-Lomelí, Paulina, Hernández-Flores, Georgina“…The MG132 + DOX treatment induced upregulation of proapoptotic genes BAX, DIABLO, NOXA, DR4, and FAS. It also induced downregulation of the antiapoptotic genes BCL-XL and SURVIVIN. …”
Publicado 2014
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375por Wen, Xiaoxing, Zhou, Jian, Zhang, Dan, Li, Jing, Wang, Qin, Feng, Nana, Zhu, Haixing, Song, Yuanlin, Li, Huayin, Bai, Chunxue“…TEM analysis demonstrated that denatonium causes large amplitude swelling of mitochondria, which was confirmed by the loss of mitochondrial membrane potential, the down-regulation of Bcl-2 protein and the subsequent enhancement of the mitochondrial release of cytochrome c and Smac/DIABLO after denatonium treatment. CONCLUSIONS: In this study, we demonstrated for the first time that denatonium damages mitochondria and thus induces apoptosis in airway epithelial cells. …”
Publicado 2015
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376“…Moreover, our results confirmed that 9-NC in nanoparticles at the level of gene expression potentiated down-regulation of Bcl-2, up regulation of Bax, and Smac/DIABLO leading to a decrease in mitochondrial membrane potential. …”
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377“…During apoptosis Bid and Bax are sufficient for mitochondrial outer membrane permeabilization, releasing pro-apoptotic proteins such as cytochrome c and Smac/Diablo into the cytoplasm. In most cells, both Bid and Bax are cytoplasmic but bind to mitochondrial outer membranes to exert pro-apoptotic functions. …”
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378“…FKC was found to disrupt mitochondrial membrane potential, resulting in the release of Smac/DIABLO, AIF and cytochrome c into the cytoplasm. Our results also revealed that FKC induced intrinsic and extrinsic apoptosis via upregulation of the levels of pro-apoptotic proteins (Bak) and death receptors (DR5), while downregulation of the levels of anti-apoptotic proteins (XIAP, cIAP-1, c-Flip(L), Bcl-xL and survivin), resulting in the activation of caspase-3, -8 and -9 and cleavage of poly(ADP-ribose) polymerase (PARP). …”
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379por Wu, Ting-Feng, Hsu, Li-Ting, Tsang, Bo-Xian, Huang, Li-Chien, Shih, Wan-Yin, Chen, Li-Yi“…It also might evoke cell apoptosis through Diablo over-expression. CONCLUSIONS: The results of this study provide a global picture to further investigate the anticancer molecular mechanism of pomegranate fruit. …”
Publicado 2016
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380por Turillazzi, Emanuela, Neri, Margherita, Cerretani, Daniela, Cantatore, Santina, Frati, Paola, Moltoni, Laura, Busardò, Francesco Paolo, Pomara, Cristoforo, Riezzo, Irene, Fineschi, Vittorio“…Immunohistochemical study and Western blot analysis were performed to evaluate cells' apoptosis and to measure the effects of expression of specific mediators, such as NF‐κB (nuclear factor kappa‐light‐chain‐enhancer of activated B cells), Bcl‐2 (B‐cell lymphoma 2), SMAC/DIABLO (second mitochondria‐derived activator of caspases/direct IAP‐binding protein with low PI) and VMAT2 (vesicular monoamine transporter 2) on apoptosis. …”
Publicado 2016
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