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1por Vall, Andreu, Sabnis, Yogesh, Shi, Jiye, Class, Reiner, Hochreiter, Sepp, Klambauer, Günter“…Drug-induced liver injury (DILI) is a common reason for the withdrawal of a drug from the market. …”
Publicado 2021
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2por Robles-Díaz, Mercedes, Medina-Caliz, Inmaculada, Stephens, Camilla, Andrade, Raúl J., Lucena, M. Isabel“…A major limitation in DILI diagnosis and prediction is the current lack of specific biomarkers. …”
Publicado 2016
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3por Uetrecht, JackEnlace del recurso
Publicado 2019
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4“…While acute and dose-dependent DILI, namely, intrinsic DILI, is predictable and often reproducible in preclinical models, the nature of idiosyncratic DILI (iDILI) limits its mechanistic understanding due to the complex disease pathogenesis, and recapitulation using in vitro and in vivo models is extremely challenging. …”
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5por Amin, Ruhul, De Oliveira, Telma Joana Corte Real, Da Cunha, Mateus, Brown, Tanya Wells, Favin, Michael, Cappelier, Kelli“…Almost all families in Dili would be motivated to have their children immunized if services were convenient, reliable, friendly, and informative.…”
Publicado 2013
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6por Watkins, Paul B.“…The drug‐induced liver injury (DILI)‐sim Initiative is a public‐private partnership involving scientists from industry, academia, and the US Food and Drug Administration (FDA). …”
Publicado 2019
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7por Björnsson, Einar S.“…Drug‐induced liver injury (DILI) should be considered in all patients with recent elevation of liver tests without obvious etiology and normal hepatobiliary imaging. …”
Publicado 2021
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8por Wang, Jiabo, Song, Haibo, Ge, Feilin, Xiong, Peng, Jing, Jing, He, Tingting, Guo, Yuming, Shi, Zhuo, Zhou, Chao, Han, Zixin, Han, Yanzhong, Niu, Ming, Bai, Zhaofang, Luo, Guangbin, Shen, Chuanyong, Xiao, Xiaohe“…Drug-induced liver injury (DILI) is a type of bizarre adverse drug reaction (ADR) damaging liver (L-ADR) which may lead to substantial hospitalizations and mortality. …”
Publicado 2022
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10por Regev, Arie, Seeff, Leonard B., Merz, Michael, Ormarsdottir, Sif, Aithal, Guruprasad P., Gallivan, Jim, Watkins, Paul B.“…Causality assessment is a critical step in establishing the diagnosis of drug induced liver injury (DILI) during drug development. DILI may resemble almost any type of liver disease, and often presents a serious challenge to clinical investigators and drug makers. …”
Publicado 2014
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11por Quintás, Guillermo, Martínez-Sena, Teresa, Conde, Isabel, Pareja Ibars, Eugenia, Kleinjans, Jos, Castell, José V.“…Drug-induced liver injury (DILI) is an adverse toxic hepatic clinical reaction associated to the administration of a drug that can occur both at early clinical stages of drug development, as well after normal clinical usage of approved drugs. …”
Publicado 2021
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12“…Drug-induced liver injury (DILI) is one of the most frequent adverse clinical reactions and a relevant cause of morbidity and mortality. …”
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13por Woodhead, J L, Yang, K, Brouwer, K L R, Siler, S Q, Stahl, S H, Ambroso, J L, Baker, D, Watkins, P B, Howell, B A“…Bile salt export pump (BSEP) inhibition has been proposed to be an important mechanism for drug-induced liver injury (DILI). Modeling can prioritize knowledge gaps concerning bile acid (BA) homeostasis and thus help guide experimentation. …”
Publicado 2014
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14por Kuna, Lucija, Božić, Ivana, Kizivat, Tomislav, Bojanić, Kristina, Mršo, Margareta, Kralj, Edgar, Smolić, Robert, Wu, George Y., Smolić, Martina“…BACKGROUND: Drug-induced Liver Injury (DILI) is an important cause of acute liver failure cases in the United States, and remains a common cause of withdrawal of drugs in both preclinical and clinical phases. …”
Publicado 2018
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15“…The difficulties describing mechanistic events can be traced back to the lack of an animal model of experimental idiosyncratic DILI that can mimic the genetic requirements of human idiosyncratic DILI. …”
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17por Hey-Hadavi, Juliana, Seekins, Daniel, Palmer, Melissa, Coffey, Denise, Caminis, John, Abdullaev, Sandzhar, Patwardhan, Meenal, Tyler, Haifa, Raheja, Ritu, Stanley, Ann Marie, Pineda-Salgado, Liliam, Bourdet, David L., Andrade, Raul J., Hayashi, Paul H., Dimick-Santos, Lara, Rockey, Don C., Estilo, Alvin“…Causality assessment for suspected drug-induced liver injury (DILI) during drug development and following approval is challenging. …”
Publicado 2021
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18“…The molecular weight and hydrophobicity of the drug, as well as the steady-state total plasma levels, may positively correlate with the DILI potential. Depending on the phase of drug development, the physicochemical properties, dosing, and cut-off values of BSEP IC(50) ≤ 25–50 µM or total C(ss,plasma)/BSEP IC(50) ≥ 0.1 may be an indication for further testing to minimize the risk of DILI liability.…”
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