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  1. 241
    “…CONCLUSION/SIGNIFICANCE: The models we present imply that producers of potent bacteriocins that trigger a strong response in neighboring bacteriocinogenic strains are doomed, while producers of weak bacteriocins that trigger a mild response in bacteriocinogenic strains flourish. …”
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    The Weak Shall Inherit: Bacteriocin-Mediated Interactions in Bacterial Populations
  2. 242
    “…CONCLUSIONS/SIGNIFICANCE: Our results refute the assumption that vector control actions performed in marginalized communities of the Gran Chaco are doomed to fail. The larger-than-expected impacts of the intervention program were likely associated with the combined effects of high-coverage, professional insecticide spraying followed by systematic vector surveillance-and-response, broad geographic coverage creating a buffer zone, frequent housing replacement and residential mobility. …”
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    Beating the odds: Sustained Chagas disease vector control in remote indigenous communities of the Argentine Chaco over a seven-year period
  3. 243
    por Foster, S., Mohler-Kuo, M.
    Publicado 2021
    “…Four prototypical subgroups were evident: “preventive” (alcohol policy environment decreased RSOD risk), “causative” (alcohol policy environment increased RSOD risk), “immune” (no effect due to low RSOD baseline risk), and “doomed” (no effect due to high RSOD baseline risk). …”
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    Evidence of substantial heterogeneity in the preventive effect of stricter alcohol policy environments in young Swiss men
  4. 244
    por Riazuelo, Hélène
    Publicado 2023
    “…Various developments are possible, some of which can be envisaged as leading to more positive outcomes, while others appear as if blocked or doomed to failure. CLINICAL DATA AND METHOD: This clinical study is the result of twelve analytically oriented psychotherapeutic follow-ups. …”
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    Becoming a mother when suffering from a chronic illness
  5. 245
    “…Achievement of these benefits in reality is not an easy task, and there are lots of plans in this field which are doomed to failure. About 50% of the implementation plans of clinical information systems in health care organizations have failed, and this trend is significantly affecting industrial countries. …”
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    An evaluation of the risk factors associated with implementing projects of health information technology by fuzzy combined ANP-DEMATEL
  6. 246
    por Pepe Altarelli, Monica
    Publicado 2019
    “…I remember he said to me, “Mop (a funny contraction between my first and last names, which he often used), I’m doomed” (“Mop, sono fottuto”). Guido used to keep a journal, in which he jotted down a few lines every day. …”
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    Flashes from Guido’s life
  7. 247
    por Dooms, M.
    Publicado 2023
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    Orphan medical devices have come a long way
  8. 248
    por Dooms, M.
    Publicado 2023
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    Pharmacists are initiators in palliative care for patients with rare diseases
  9. 249
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    A bifurcated role for c-Maf in Th2 and Tfh2 cells during helminth infection
  10. 250
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    IL-15 Augments TCR-Induced CD4(+) T Cell Expansion In Vitro by Inhibiting the Suppressive Function of CD25(High) CD4(+) T Cells
  11. 251
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    Advances in the quantification of mitochondrial function in primary human immune cells through extracellular flux analysis
  12. 252
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    Regionally Compartmentalized Resident Memory T Cells Mediate Naturally Acquired Protection Against Pneumococcal Pneumonia
  13. 253
    “…RESULTS: We show that, during the regression phase, tumors of mice treated with a single vaccination of STxB-E7 + IFNα harbor fewer activated CD8 T cells and monocytes than tumors doomed to fully regress after two vaccinations. In contrast, the systemic injection of an anti-PD1 Ab combined with the peri-tumoral injection of IFNα in this time frame promotes infiltration of activated CD8 T cells and myeloid cells, which, together, exert a high cytotoxicity in vitro against TC1 cells. …”
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    Local IFNα enhances the anti-tumoral efficacy of systemic anti-PD1 to prevent tumor relapse
  14. 254
    “…Further interrogation of TLS, using POLη as a representative TLS polymerase, demonstrated that α-HPV16 E6 blocks TLS polymerase induction by degrading p53. This doomed the pathway, leading to increased replication fork collapse and sensitivity to treatments that cause replication stress (e.g., UV and Cisplatin). …”
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    High Risk α-HPV E6 Impairs Translesion Synthesis by Blocking POLη Induction
  15. 255
    por Izadifar, Morteza
    Publicado 2022
    “…Life, whatsoever it is, is a temporal flux. Everything is doomed to change often apparently beyond our awareness. …”
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    The Neurobiological Basis of the Conundrum of Self-continuity: A Hypothesis
  16. 256
    por Nowak, Andrzej
    Publicado 2022
    “…Should we be worried about boundary conditions? Are we doomed to give up all our data, or are there privacy-friendly solutions to common data problems?…”
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    1st series on Data Protection - Battling robots for our data, privacy and humanity - Lecture 1
  17. 257
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    Interleukin-2 enhances CD4(+) T cell memory by promoting the generation of IL-7Rα–expressing cells
  18. 258
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    Endogenous DKK1 and FRZB Regulate Chondrogenesis and Hypertrophy in Three-Dimensional Cultures of Human Chondrocytes and Human Mesenchymal Stem Cells
  19. 259
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    Lung Aeration in COVID-19 Pneumonia by Ultrasonography and Computed Tomography
  20. 260
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    The impact of endoscopic lung volume reduction on physical activity coaching in patients with severe emphysema
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