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  1. 21881
    “…Finally, comparison of the Drosophila DmRCC1 and the Arabidopsis UVR8 crystal structures revealed that critical histone- and DNA-interaction residues apparent in DmRCC1 are not conserved in UVR8. …”
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    Revisiting chromatin binding of the Arabidopsis UV-B photoreceptor UVR8
  2. 21882
    “…Conservative molecular clock estimates based on synonymous substitution rates for species of Anopheles mosquitoes and the fruit fly, Drosophila melanogaster, suggest these events occurred within the last 50 MYA. …”
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    Paralog analyses reveal gene duplication events and genes under positive selection in Ixodes scapularis and other ixodid ticks
  3. 21883
    “…CONCLUSIONS: All together these data make Heliconius butterflies one of the very few insects outside Drosophila where IRs have been characterized in detail. …”
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    Genome-wide analysis of ionotropic receptors provides insight into their evolution in Heliconius butterflies
  4. 21884
    “…McClintock’s Ac, the autonomous element of the Ac/Ds system, together with hobo from Drosophila and Tam3 from snapdragon define an ancient and diverse DNA transposon superfamily named hAT. …”
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    Active recombinant Tol2 transposase for gene transfer and gene discovery applications
  5. 21885
    “…All of the elements tested in vivo were confirmed to drive gene expression in transgenic Drosophila reporter assays. Of the >13,000 single nucleotide polymorphisms (SNPs) recently identified in dengue virus-susceptible and refractory mosquito strains, 3365 were found to map to FPs. …”
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    High-throughput cis-regulatory element discovery in the vector mosquito Aedes aegypti
  6. 21886
    “…Genes of subfamilies ABCA, ABCC and ABCH were found to be expanded in P. xylostella compared with those in Bombyx mori, Manduca sexta, Heliconius melpomene, Danaus plexippus, Drosophila melanogaster, Tetranychus urticae and Homo sapiens. …”
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    Characterization and expression profiling of ATP-binding cassette transporter genes in the diamondback moth, Plutella xylostella (L.)
  7. 21887
    “…We confront the neutral and panmictic model to “ideal” empirical data (in silico RAD-sequencing) using full genomes from natural populations of the fruit fly Drosophila melanogaster and the fungus Shizophyllum commune, harbouring respectively moderate and high genetic diversity. …”
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    How and how much does RAD-seq bias genetic diversity estimates?
  8. 21888
    “…Exploiting the complementary advantages of two insect models (Drosophila melanogaster and Manduca sexta), we have investigated the regulation of APPL trafficking and processing with respect to different aspects of neuronal development. …”
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    Amyloid Precursor Proteins Are Dynamically Trafficked and Processed during Neuronal Development
  9. 21889
    “…This is illustrated by the fact that the model was also able to identify another new LPMO family in Drosophila melanogaster. Furthermore, the Hidden Markov model was used to verify the more distant blast hits from the new fungal family of LPMOs, which belong to the Bivalves, Stony corals and Sea anemones. …”
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    The discovery of novel LPMO families with a new Hidden Markov model
  10. 21890
    “…Our findings suggest that the molecular machinery and mechanisms for executing Bcl-2-mediated apoptosis as observed in mammals are evolutionary ancient, with early regulation of apoptotic machineries closely resembling their modern counterparts in mammals rather than Caenorhabditis elegans or drosophila.…”
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    Structural insight into an evolutionarily ancient programmed cell death regulator – the crystal structure of marine sponge BHP2 bound to LB-Bak-2
  11. 21891
    “…To that end, we have previously reported the expression of a novel protein vaccine for malaria using the ExpreS(2)Drosophila melanogaster Schneider 2 stable cell line system, however, a very low overall process yield (typically <5% recovery of hexa-histidine-tagged protein) meant the initial purification strategy was not suitable for scale-up and clinical biomanufacture of such a vaccine. …”
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    Accelerating the clinical development of protein-based vaccines for malaria by efficient purification using a four amino acid C-terminal ‘C-tag’
  12. 21892
    “…Consistent with the findings in mice, expression of NT in Drosophila midgut EE cells results in increased lipid accumulation in the midgut, fat body, and oenocytes (specialized hepatocyte-like cells) and decreased AMPK activation. …”
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    An obligatory role for neurotensin in high fat diet-induced obesity
  13. 21893
    “…Evolutionary comparisons revealed the existence of a single FAM20 gene in the simple vertebrate Ciona intestinalis and the invertebrate worm Caenorhabditis elegans and two genes in two insect species, Drosophila melanogaster and Anopheles gambiae. Six FAM20 family members were identified in the genome of the pufferfish, Fugu rubripes and five members in the zebrafish, Danio rerio. …”
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    FAM20: an evolutionarily conserved family of secreted proteins expressed in hematopoietic cells
  14. 21894
    por Saha, Surya, Hosmani, Prashant S, Villalobos-Ayala, Krystal, Miller, Sherry, Shippy, Teresa, Flores, Mirella, Rosendale, Andrew, Cordola, Chris, Bell, Tracey, Mann, Hannah, DeAvila, Gabe, DeAvila, Daniel, Moore, Zachary, Buller, Kyle, Ciolkevich, Kathryn, Nandyal, Samantha, Mahoney, Robert, Van Voorhis, Joshua, Dunlevy, Megan, Farrow, David, Hunter, David, Morgan, Taylar, Shore, Kayla, Guzman, Victoria, Izsak, Allison, Dixon, Danielle E, Cridge, Andrew, Cano, Liliana, Cao, Xiaolong, Jiang, Haobo, Leng, Nan, Johnson, Shannon, Cantarel, Brandi L, Richards, Stephen, English, Adam, Shatters, Robert G, Childers, Chris, Chen, Mei-Ju, Hunter, Wayne, Cilia, Michelle, Mueller, Lukas A, Munoz-Torres, Monica, Nelson, David, Poelchau, Monica F, Benoit, Joshua B, Wiersma-Koch, Helen, D’Elia, Tom, Brown, Susan J
    Publicado 2017
    “…However, knowledge transfer from well-curated reference genomes such as that of Drosophila melanogaster to newly sequenced ones is challenging due to the complexity and diversity of insect genomes. …”
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    Improved annotation of the insect vector of citrus greening disease: biocuration by a diverse genomics community
  15. 21895
    “…It was also closely related to Pao from Bombyx mori and to Ninja of Drosophila simulans. Sinbad was only distantly related to the other schistosome LTR retrotransposons Boudicca, Gulliver, Saci-2, Saci-3, and Fugitive, which are gypsy-like. …”
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    The Sinbad retrotransposon from the genome of the human blood fluke, Schistosoma mansoni, and the distribution of related Pao-like elements
  16. 21896
    “…Although slight GC-skew peaks, including opposite skews (C < G), were detected around the TSS of genes in human and Drosophila, they were qualitatively and quantitatively different from those identified in plants. …”
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    GC-compositional strand bias around transcription start sites in plants and fungi
  17. 21897
    por Patel, Vir D., Capra, John A.
    Publicado 2017
    “…Consistent with recent work in Drosophila, our results support a model in which miRNAs increase their expression and functional regulatory interactions over evolutionary time, and thus older miRNAs have increased potential to cause disease. …”
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    Ancient human miRNAs are more likely to have broad functions and disease associations than young miRNAs
  18. 21898
    por Tsurumi, Amy, Zhao, Connie, Li, Willis X.
    Publicado 2017
    “…Considering the significant role of the JAK/STAT pathway, we used the simple Drosophila system in which the non-canonical pathway was initially characterized, to compare putative canonical versus non-canonical transcriptional targets across the genome. …”
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    Canonical and non-canonical JAK/STAT transcriptional targets may be involved in distinct and overlapping cellular processes
  19. 21899
    “…Transforming growth factor (TGF)-β1 is one of the key factors in the development of liver fibrosis, which also promotes extracellular matrix (ECM) formation. Drosophila mothers against decapentaplegic 7 (Smad7) is an essential negative regulator in the TGF-β1/Smad signaling pathway. …”
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    Smad7-overexpressing rat BMSCs inhibit the fibrosis of hepatic stellate cells by regulating the TGF-β1/Smad signaling pathway
  20. 21900
    “…In this regard, Six1 gene, a vertebrate homolog of Drosophila Sine Oculis, is known to be required for development of ear, nose, tongue and cranial skeleton. …”
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    Respective contribution of the cephalic neural crest and mesoderm to SIX1-expressing head territories in the avian embryo
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