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  1. 22141
    por Papanicolaou, Alexie, Schetelig, Marc F., Arensburger, Peter, Atkinson, Peter W., Benoit, Joshua B., Bourtzis, Kostas, Castañera, Pedro, Cavanaugh, John P., Chao, Hsu, Childers, Christopher, Curril, Ingrid, Dinh, Huyen, Doddapaneni, HarshaVardhan, Dolan, Amanda, Dugan, Shannon, Friedrich, Markus, Gasperi, Giuliano, Geib, Scott, Georgakilas, Georgios, Gibbs, Richard A., Giers, Sarah D., Gomulski, Ludvik M., González-Guzmán, Miguel, Guillem-Amat, Ana, Han, Yi, Hatzigeorgiou, Artemis G., Hernández-Crespo, Pedro, Hughes, Daniel S. T., Jones, Jeffery W., Karagkouni, Dimitra, Koskinioti, Panagiota, Lee, Sandra L., Malacrida, Anna R., Manni, Mosè, Mathiopoulos, Kostas, Meccariello, Angela, Murali, Shwetha C., Murphy, Terence D., Muzny, Donna M., Oberhofer, Georg, Ortego, Félix, Paraskevopoulou, Maria D., Poelchau, Monica, Qu, Jiaxin, Reczko, Martin, Robertson, Hugh M., Rosendale, Andrew J., Rosselot, Andrew E., Saccone, Giuseppe, Salvemini, Marco, Savini, Grazia, Schreiner, Patrick, Scolari, Francesca, Siciliano, Paolo, Sim, Sheina B., Tsiamis, George, Ureña, Enric, Vlachos, Ioannis S., Werren, John H., Wimmer, Ernst A., Worley, Kim C., Zacharopoulou, Antigone, Richards, Stephen, Handler, Alfred M.
    Publicado 2016
    “…Its close relationship to Drosophila, and other insect species important to agriculture and human health, will further comparative functional and structural studies of insect genomes that should broaden our understanding of gene family evolution. …”
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    The whole genome sequence of the Mediterranean fruit fly, Ceratitis capitata (Wiedemann), reveals insights into the biology and adaptive evolution of a highly invasive pest species
  2. 22142
    “…Finally, the profiling of a Drosophila melanogaster microbiome using the set of six primer pairs provided a ~ 100-fold increase in resolution and thus enabling efficient downstream analysis. …”
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    Combining 16S rRNA gene variable regions enables high-resolution microbial community profiling
  3. 22143
    por Abi-Dargham, Anissa
    Publicado 2018
    “…He demonstrated these dysfunctions in brains of Drosophila melanogaster expressing hDAT ∆N336. Furthermore, these flies are hyperactive and display fear and impaired social interactions, traits associated with impaired DA neurotransmission. …”
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    27. THE ROLE OF DOPAMINE IN SHAPING CIRCUITRY RELATED TO SCHIZOPHRENIA AND ADDICTION
  4. 22144
    “…BACKGROUND: Our previous studies demonstrated that eyes absent homolog 4 (EYA4), a member of the eye development-related EYA family in Drosophila, is frequently methylated and silenced in hepatocellular carcinoma (HCC) specimens and associated with shorter survival. …”
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    EYA4 inhibits hepatocellular carcinoma growth and invasion by suppressing NF-κB-dependent RAP1 transactivation
  5. 22145
    “…Our TEs analysis revealed a massive recent accumulation of TEs equivalent to the size of entire Drosophila genomes, which likely explains the large genome sizes in grasshoppers. …”
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    Comparative analysis of morabine grasshopper genomes reveals highly abundant transposable elements and rapidly proliferating satellite DNA repeats
  6. 22146
    “…We furthermore detected in the coconut crab a significantly proliferated HOX gene, caudal, that has been associated with posterior development in Drosophila, but we could not definitively associate this gene with carcinization in the Anomura since it is also significantly proliferated in the ornate spiny lobster. …”
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    Comparative genomics of the coconut crab and other decapod crustaceans: exploring the molecular basis of terrestrial adaptation
  7. 22147
    “…MATERIALS AND METHODS: Tankyrase-binding motif (TBM) sequences in hVCL gene were identified and VCL sequences from various vertebrates, Drosophila melanogaster and Caenorhabditis elegans were aligned and compared. …”
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    First body of evidence suggesting a role of a tankyrase-binding motif (TBM) of vinculin (VCL) in epithelial cells
  8. 22148
    “…Several differences during IFM development were observed between A. aegypti (Nematoceran) and Drosophila melanogaster (Brachyceran) and, similitudes with Chironomus sp. were observed as this insect is a Nematoceran, which is taxonomically closer to A. aegypti and share the same number of larval stages. …”
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    Development of the indirect flight muscles of Aedes aegypti, a main arbovirus vector
  9. 22149
    “…The mechanism of APP.C99 pathogenesis is incompletely understood. We used Drosophila models expressing APP.C99 with the native ER-targeting signal of human APP, expressing full-length human APP only, or co-expressing full-length human APP and β-secretase (BACE), to investigate mechanisms of APP.C99 pathogenesis. …”
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    Inefficient quality control of ribosome stalling during APP synthesis generates CAT-tailed species that precipitate hallmarks of Alzheimer’s disease
  10. 22150
    “…BACKGROUND: Most of the known genes required for developmental processes have been identified by genetic screens in a few well-studied model organisms, which have been considered representative of related species, and informative—to some degree—for human biology. The fruit fly Drosophila melanogaster is a prime model for insect genetics, and while conservation of many gene functions has been observed among bilaterian animals, a plethora of data show evolutionary divergence of gene function among more closely-related groups, such as within the insects. …”
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    Screens in fly and beetle reveal vastly divergent gene sets required for developmental processes
  11. 22151
    “…BACKGROUND: In both Drosophila and mammals, the achaete-scute (ASC/ASCL) proneural bHLH transcription factors are expressed in the developing central and peripheral nervous systems, where they function during specification and maintenance of the neural stem cells in opposition to Notch signaling. …”
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    ASC proneural factors are necessary for chromatin remodeling during neuroectodermal to neuroblast fate transition to ensure the timely initiation of the neural stem cell program
  12. 22152
    “…OBJECTIVE: The present study aims to explore the correlation of the transforming growth factor β (TGF-β), drosophila mothers against decapentaplegic protein gene (SMAD) 2/3/4, and leukemia inhibitory factors (LIF) with the cyst formation of hepatic Echinococcus granulosus in young children. …”
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    The role of the TGF-β/LIF signaling pathway mediated by SMADs during the cyst formation of Echinococcus in young children
  13. 22153
    “…Importantly, uncoupling these two processes, as seen in cells lacking SLC3A2 or expressing ANCL-associated DNAJC5 mutants, generates DNAJC5-containing AFSMs resembling NCL patient-derived lipofuscin and induces neurodegeneration in a Drosophila ANCL model. These findings suggest that MAPS safeguards microautophagy to avoid DNAJC5-associated lipofuscinosis and neurodegeneration. …”
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    Abnormal triaging of misfolded proteins by adult neuronal ceroid lipofuscinosis-associated DNAJC5/CSPα mutants causes lipofuscin accumulation
  14. 22154
    por Mead, Edward Andrew, Tu, Zhijian
    Publicado 2008
    “…Two clusters of miRNAs were found within introns of orthologous genes in An. gambiae, Ae. aegypti, and Drosophila melanogaster. Mature miRNAs were detected in An. stephensi for all of the nine selected miRNAs, including the four novel miRNAs (miR-x1- miR-x4), either by northern blot or by Ribonuclease Protection Assay. …”
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    Cloning, characterization, and expression of microRNAs from the Asian malaria mosquito, Anopheles stephensi
  15. 22155
    “…Selected PCP pathway genes (cadherin EGF LAG seven-pass G-type receptor 3 (CELSR3), prickle homolog 4 (Drosophila) (PRICKLE4), dishevelled-associated activator of morphogenesis 1 (DAAM1), profilin 2 (PFN2), protocadherin 9 (PCDH9), protocadherin α1 (PCDHA1), protocadherin β17 pseudogene (PCDHB17), protocadherin β3 (PCDHB3), sprouty homolog 1 (SPRY1) and protein tyrosine kinase 7 (PTK7)) were found to be more highly expressed in Stem-A than non Stem-A subgroup of OC. …”
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    FZD7 drives in vitro aggressiveness in Stem-A subtype of ovarian cancer via regulation of non-canonical Wnt/PCP pathway
  16. 22156
    “…The SVM models were validated with data from rat (Rattus norvegicus), pig (Sus scrofa) and fruit fly (Drosophila melanogaster), and obtained more than 84.00% accuracy in all these organisms. …”
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    A Support Vector Machine based method to distinguish long non-coding RNAs from protein coding transcripts
  17. 22157
    “…We identified highly conserved paralogs of insect P450s that likely play a role in the development of resistance to imidacloprid: Drosophila Cyp6g1 (CYP6345J1) and Bemisia tabaci CYP4C64 (CYP4LE1). …”
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    Global transcriptome profiling and functional analysis reveal that tissue-specific constitutive overexpression of cytochrome P450s confers tolerance to imidacloprid in palm weevils in date palm fields
  18. 22158
    “…Porcine, avian, zebrafish, C. elegans, canine, equine, and drosophila model systems were also reported. CONCLUSIONS: Over the past 30 years, there were 262 publications on MH and RYR1-RM preclinical model systems featuring more than 200 unique RYR1 variations tested in a broad range of species. …”
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    Preclinical model systems of ryanodine receptor 1-related myopathies and malignant hyperthermia: a comprehensive scoping review of works published 1990–2019
  19. 22159
    “…Protein expression of proneural marker ASCL1 (enriched in SHH-1B) and glial markers OLIG2 and GFAP (absent in SHH-2) as well as global mRNA expression patterns differed, but all subgroups were characterized by overexpression of SHH as well as Notch pathway members. In a Drosophila model, knockdown of Snr1 (the fly homologue of SMARCB1) in hedgehog activated cells not only altered hedgehog signaling, but also caused aberrant Notch signaling and formation of tumor-like structures. …”
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    ATRT–SHH comprises three molecular subgroups with characteristic clinical and histopathological features and prognostic significance
  20. 22160
    “…Two commonly overexpressed genes, GSTe2 and CYP6Z2, were functionally validated. Transgenic Drosophila melanogaster flies expressing GSTe2 exhibited extremely high DDT and permethrin resistance (mortalities <10% in 24h). …”
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    Molecular drivers of insecticide resistance in the Sahelo-Sudanian populations of a major malaria vector Anopheles coluzzii
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