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261por Posey, Karen L, Jones, Leslie B, Cerda, Rosalinda, Bajaj, Monica, Huynh, Thao, Hardin, Paul E, Hardin, Susan H“…To accelerate the molecular analysis of brain function in Drosophila we constructed a cDNA library exclusively from adult brains. …”
Publicado 2001
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262“…We test this hypothesis in Drosophila neuroblasts (NBs) tracing photo converted centrioles and a daughter-centriole-specific marker generated by cloning the Drosophila homologue of human Centrobin. …”
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263por Kharchenko, Peter V., Alekseyenko, Artyom A., Schwartz, Yuri B., Minoda, Aki, Riddle, Nicole C., Ernst, Jason, Sabo, Peter J., Larschan, Erica, Gorchakov, Andrey A., Gu, Tingting, Linder-Basso, Daniela, Plachetka, Annette, Shanower, Gregory, Tolstorukov, Michael Y., Luquette, Lovelace J., Xi, Ruibin, Jung, Youngsook L., Park, Richard W., Bishop, Eric P., Canfield, Theresa P., Sandstrom, Richard, Thurman, Robert E., MacAlpine, David M., Stamatoyannopoulos, John A., Kellis, Manolis, Elgin, Sarah C. R., Kuroda, Mitzi I., Pirrotta, Vincenzo, Karpen, Gary H., Park, Peter J.“…We present a genome-wide chromatin landscape for Drosophila melanogaster based on 18 histone modifications, summarized by 9 prevalent combinatorial patterns. …”
Publicado 2010
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264“…BACKGROUND: Mutations that cause learning and memory defects in Drosophila melanogaster have been found to also compromise visual responsiveness and attention. …”
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265“…Based on the genome sequences of 12 Drosophila species we traced the evolution of the PPP catalytic subunits and noted a substantial expansion of the gene family. …”
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267“…Here we describe a visual place-learning platform and demonstrate that Drosophila are capable of forming and retaining visual place memories to guide selective navigation. …”
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268“…BACKGROUND: Crumbs (Crb), a cell polarity gene, has been shown to provide a positional cue for the apical membrane domain and adherens junction during Drosophila photoreceptor morphogenesis. It has recently been found that stable microtubules in developing Drosophila photoreceptors were linked to Crb localization. …”
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269“…Conservation of major signaling pathways between humans and flies has made Drosophila a useful model organism for cancer research. …”
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270por Zoltowski, Brian D., Vaidya, Anand T., Top, Deniz, Widom, Joanne, Young, Michael W., Crane, Brian R.“…Herein, we report a 2.3 Å resolution crystal structure of Drosophila CRY with an intact C-terminus. The C-terminal helix docks in the analogous groove that binds DNA substrates in PLs. …”
Publicado 2011
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271“…The current inundation of transcriptome sequencing data from Drosophila provides an unprecedented opportunity to gain a comprehensive view of alternative splicing.…”
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272“…Many of the cellular mechanisms underlying host responses to pathogens have been well conserved during evolution. As a result, Drosophila can be used to deconstruct many of the key events in host-pathogen interactions by using a wealth of well-developed molecular and genetic tools. …”
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273“…RESULTS: To investigate possible mechanisms of intron gain and loss, we identified 189 intron gain and 297 intron loss events among 11 Drosophila species. We then investigated these events for signatures of previously proposed mechanisms of intron gain and loss. …”
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274“…However, the numt content of different genomes and their properties is not uniform, and study of these differences provides insight into the mechanisms and dynamics of genome evolution in different organisms. In the genus Drosophila, numts have previously only been identified on a genome-wide scale in the melanogaster subgroup. …”
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275“…For example, NOMPC, a TRP ion channel, acts as a mechanotransducer in Drosophila melanogaster(5) and Caenorhabditis elegans(6,7); however, it has no orthologues in mammals. …”
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276por Vanderploeg, Jessica, Vazquez Paz, L Lourdes, MacMullin, Allison, Jacobs, J Roger“…Here we characterise the requirement of Integrins in a genetic model of vasculogenesis, the formation of the heart in Drosophila. RESULTS: As with vertebrates, the Drosophila heart arises from lateral mesoderm that migrates medially to meet their contralateral partners, to then assemble a midline vessel. …”
Publicado 2012
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277“…In contrast, model organisms such as C. elegans, Drosophila, and rodents have facilitated the search for specific genes that affect lifespan. …”
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278“…At present, the development of TDP-43-related Drosophila models has further strengthened the hypothesis that both TDP-43 “loss-of-function” and “gain-of-function” mechanisms can contribute to disease. …”
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279“…For example, interactions between cardiogenic transcription factors, discovered in Drosophila, are also critical for adult heart function in flies and mammals. …”
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280“…Higher-order genome organization plays an important role in transcriptional regulation. In Drosophila, somatic pairing of homologous chromosomes can lead to transvection, by which the regulatory region of a gene can influence transcription in trans. …”
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