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261por Becker, Kolja, Bluhm, Alina, Casas-Vila, Nuria, Dinges, Nadja, Dejung, Mario, Sayols, Sergi, Kreutz, Clemens, Roignant, Jean-Yves, Butter, Falk, Legewie, StefanEnlace del recurso
Publicado 2018
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263por Schiemann, Ronja, Lammers, Kay, Janz, Maren, Lohmann, Jana, Paululat, Achim, Meyer, Heiko“…In the present study, we analysed a set of neuropeptides and peptide hormones for their ability to modulate cardiac function in semi-intact larval Drosophila melanogaster. We identified numerous peptides that significantly affected heart parameters such as heart rate, systolic and diastolic interval, rhythmicity, and contractility. …”
Publicado 2018
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266por George, Laura Faith, Pradhan, Sarala Joshi, Mitchell, Danae, Josey, Megan, Casey, Justin, Belus, Matthew T., Fedder, Karlie N., Dahal, Giri Raj, Bates, Emily Anne“…However, little is known about the scope of specific ion-channel types that impinge upon developmental pathways. The Drosophila melanogaster wing is an excellent model in which to address this problem as wing vein patterning is acutely sensitive to changes in developmental pathways. …”
Publicado 2019
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267por Varga, Gergely I. B., Csordás, Gábor, Cinege, Gyöngyi, Jankovics, Ferenc, Sinka, Rita, Kurucz, Éva, Andó, István, Honti, Viktor“…The larvae of Drosophila melanogaster respond to immune induction with the production of special effector blood cells, the lamellocytes, which encapsulate and subsequently kill the invader. …”
Publicado 2019
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268por Shokri, Leila, Inukai, Sachi, Hafner, Antonina, Weinand, Kathryn, Hens, Korneel, Vedenko, Anastasia, Gisselbrecht, Stephen S., Dainese, Riccardo, Bischof, Johannes, Furger, Edy, Feuz, Jean-Daniel, Basler, Konrad, Deplancke, Bart, Bulyk, Martha L.Enlace del recurso
Publicado 2019
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269“…The most invaluable studies have been performed using disease model organisms, such as mice, fruit flies, and worms. Among them, Drosophila melanogaster has emerged as an excellent model organism to study both environmental and genetic factors and provide insights to the pathways relevant for PD pathogenesis, facilitating development of therapeutic strategies. …”
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270por Highfill, Chad A., Baker, Brandon M., Stevens, Stephenie D., Anholt, Robert R. H., Mackay, Trudy F. C.“…Whereas neural mechanisms that mediate the effects of these drugs are well-characterized, genetic factors that account for individual variation in susceptibility to substance abuse and addiction remain largely unknown. Drosophila melanogaster can serve as a translational model for studies on substance abuse, since flies have a dopamine transporter that can bind cocaine and methamphetamine, and exposure to these compounds elicits effects similar to those observed in people, suggesting conserved evolutionary mechanisms underlying drug responses. …”
Publicado 2019
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272por Coronado-Zamora, Marta, Salvador-Martínez, Irepan, Castellano, David, Barbadilla, Antonio, Salazar-Ciudad, Isaac“…Previous studies of the evolution of genes expressed at different life-cycle stages of Drosophila melanogaster have not been able to disentangle adaptive from nonadaptive substitutions when using nonsynonymous sites. …”
Publicado 2019
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273por Salminen, Tiina S., Cannino, Giuseppe, Oliveira, Marcos T., Lillsunde, Päivi, Jacobs, Howard T., Kaguni, Laurie S.“…Drosophila melanogaster, like most animal species, displays considerable genetic variation in both nuclear and mitochondrial DNA (mtDNA). …”
Publicado 2019
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274“…Research using the model organism Drosophila melanogaster benefits from a wealth of molecular genetic resources and information useful for efficient in vivo experimentation. …”
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276por Wu, Fengming, Deng, Bowen, Xiao, Na, Wang, Tao, Li, Yining, Wang, Rencong, Shi, Kai, Luo, Dong-Gen, Rao, Yi, Zhou, Chuan“…Here we found that the neuropeptide Drosulfakinin (Dsk) modulates aggression in Drosophila melanogaster. Knock-out of Dsk or Dsk receptor CCKLR-17D1 reduced aggression. …”
Publicado 2020
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277por Bieser, Kayla L., Stamm, Joyce, Aldo, Ayala A., Bhaskara, Suneil, Clairborne, Makayla, Coronel Gómez, Joselyn N., Dean, Ron, Dowell, Aaron, Dowell, Evan, Eissa, Mathew, Fawaz, Ahmad A., Fouad-Meshriky, Michael M., Godoy, Dustin, Gonzalez, Krista, Hachem, Malak K., Hammoud, Malak F., Huffman, Anthony, Ingram, Hunter, Jackman, Alex B., Karki, Bibek, Khalil, Natalia, Khalil, Houda, Ha, Tran Khanh, Kharel, Arjun, Kobylarz, Izabell, Lomprey, Hunter, Lonnberg, Adam, Mahbuba, Safa, Massarani, Hend, Minster, Madeline, Molina, Krystina, Molitor, Lynette, Murray, Taylor, Patel, Payal M., Pechulis, Sydney, Raja, Architha, Rastegari, Gladys, Reeves, Skylar, Sabu, Niveda, Salazar, Rafael, Schulert, Devan, Senopole, Matthew D., Sportiello, Kristen, Torres, Claudia, Villalobos, Jade, Wu, Joseph, Zeigler, Stacy, Kagey, Jacob D.Enlace del recurso
Publicado 2018
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278por Pham, Tuan L. A., Binh, Tran Duy, Liu, Guanchen, Nguyen, Thanh Q. C., Nguyen, Yen D. H., Sahashi, Ritsuko, Men, Tran Thanh, Kamei, Kaeko“…In this study, we investigated the function of SerT in the development of the compound eye in Drosophila melanogaster. We found that SerT knockdown led to excessive cell death and an increased number of cells in S-phase in the posterior eye imaginal disc. …”
Publicado 2020
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279por Abdu-Allah, Gamal A. M., Seong, Keon Mook, Mittapalli, Omprakash, Ojo, James Adebayo, Sun, Weilin, Posos-Parra, Omar, Mota-Sanchez, David, Clark, John M., Pittendrigh, Barry R.“…The impact of dietary antioxidants on the toxicity of xenobiotics in insects is not well understood, in part due to the challenge of developing appropriate systems in which doses and exposure times (of both the antioxidants and the xenobiotics) can be controlled and outcomes can be easily measured. However, in Drosophila melanogaster, a well-established insect model system, both dietary factors and pesticide exposure can be easily controlled. …”
Publicado 2020
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