“…The application of these methods to the isolation of polytene and nonpolytene nuclei from Drosophila melanogaster larvae is described.…”
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“…Using a computer-based system for model building and analysis, three- dimensional models of 24 Drosophila melanogaster salivary gland nuclei have been constructed from optically or physically sectioned glands, allowing several generalizations about chromosome folding and packaging in these nuclei. …”
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“…We have determined the position within the nucleus of homologous sites of the histone gene cluster in Drosophila melanogaster using in situ hybridization and high-resolution, three-dimensional wide field fluorescence microscopy. …”
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“…The critical thermal increments are calculated for oxygen consumption in the pupae of the "wild type" fruit fly, Drosophila melanogaster, and are found to be of two types: µ = 11,500 and 16,800; above 15°C. the first value is obtained, the second, below this temperature.…”
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“…By a dissection of the data obtained by Driver on the effective periods at different temperatures in males and females of an ultrabar stock of Drosophila melanogaster it has been found that a symmetrical sigmoid curve satisfactorily describes the time course of the facet-determining reaction. …”
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“…To address this question, we systematically assessed Notch localization, processing, and signaling in a comprehensive set of Drosophila melanogaster mutants that block access of cargo to different endocytic compartments. …”
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“…In the fruit fly Drosophila melanogaster, biogenic amines take part in the regulation of various vital physiological processes such as feeding, learning/memory, locomotion, sexual behavior, and sleep/arousal. …”
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“…To better understand the role(s) of hnRNP proteins in the process of mRNA formation, we have identified and characterized the major nuclear proteins that interact with hnRNAs in Drosophila melanogaster. cDNA clones of several D. melanogaster hnRNP proteins have been isolated and sequenced, and the genes encoding these proteins have been mapped cytologically on polytene chromosomes. …”
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“…BACKGROUND: The Y chromosome of Drosophila melanogaster harbors several genes required for male fertility. …”
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“…Recent microarray studies have revealed that expression variation is abundant in many species, including Drosophila melanogaster. However, previous expression surveys in this species generally focused on a small number of laboratory strains established from derived populations. …”
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“…In this article, we characterize histone demethylase activity of the entire family of JmjC+N proteins of Drosophila melanogaster. Our results show that Lid (little imaginal discs), which is structurally homologous to JARID1, demethylates H3K4me3. …”
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“…To identify patterns left by the intimate interaction between hosts and parasites, I analysed the genomic parameters of the immune genes from 24 gene families/groups of Drosophila melanogaster. PRINCIPAL FINDINGS: Immune genes that directly interact with the pathogen (i.e. recognition and effector genes) clustered in regions of higher recombination rates. …”
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“…We directly estimated the mtDNA mutation rate by scanning the mitochondrial genome of Drosophila melanogaster lines that had undergone approximately 200 generations of spontaneous mutation accumulation (MA). …”
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“…Furthermore, for the first time to our knowledge, we were able to compare two animal proteomes (C. elegans and Drosophila melanogaster). We found that the abundances of orthologous proteins in metazoans correlate remarkably well, better than protein abundance versus transcript abundance within each organism or transcript abundances across organisms; this suggests that changes in transcript abundance may have been partially offset during evolution by opposing changes in protein abundance.…”
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