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4421por He, Xin, Li, Yanen, Khetani, Radhika, Sanders, Barry, Lu, Yue, Ling, Xu, Zhai, ChengXiang, Schatz, Bruce“…BSQA recognizes a number of entities and relations in Medline documents about the model insect, Drosophila melanogaster. For any text query, BSQA exploits entity annotation of retrieved documents to identify important concepts in different categories. …”
Publicado 2010
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4422“…BACKGROUND: Insects have multiple hemocyte morphotypes with different functions as do vertebrates, however, their hematopoietic lineages are largely unexplored with the exception of Drosophila melanogaster. METHODOLOGY/PRINCIPAL FINDINGS: To study the hematopoietic lineage of the silkworm, Bombyx mori, we investigated in vivo and in vitro differentiation of hemocyte precursors in the hematopoietic organ (HPO) into the four mature hemocyte subsets, namely, plasmatocytes, granulocytes, oenocytoids, and spherulocytes. …”
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4423“…Apical–basal polarity in Drosophila melanogaster epithelia depends on several evolutionarily conserved proteins that have been assigned to two distinct protein complexes: the Bazooka (Baz)–PAR-6 (partitioning defective 6)–atypical protein kinase C (aPKC) complex and the Crumbs (Crb)–Stardust (Sdt) complex. …”
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4424“…A recent genome-wide proteomic study revealed an extremely strong correlation between the abundances of orthologous proteins in distantly related animals, the nematode Caenorhabditis elegans and the fruit fly Drosophila melanogaster. We used the extensive protein abundance data from this study along with short-term evolutionary rates (ERs) of orthologous genes in nematodes and flies to estimate the relative contributions of structural–functional constraints and the translation rate to the evolution rate of protein-coding genes. …”
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4425“…When RNAi is applied in Drosophila melanogaster or Caenorhabditis elegans, often large dsRNAs are used. …”
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4426por Xiong, Xin, Wang, Xin, Ewanek, Ronny, Bhat, Pavan, DiAntonio, Aaron, Collins, Catherine A.“…In this study, we describe a nerve crush assay in Drosophila melanogaster to study injury signaling and regeneration mechanisms. …”
Publicado 2010
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4427“…METHODOLOGY/PRINCIPAL FINDINGS: We analyzed nucleotide variation in a subset of eight Or genes located on the 3L chromosomal arm of Drosophila melanogaster in a derived population of this species and also in a population of Drosophila pseudoobscura. …”
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4428“…By analyzing orthologs in Drosophila melanogaster, Acyrthosiphon pisum, and Ciona intestinalis, we show genes that were short and long in the past are now preferentially situated in hyper- and hypomethylated classes respectively, in the honeybee. …”
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4429por Hatch, Emily M., Kulukian, Anita, Holland, Andrew J., Cleveland, Don W., Stearns, Tim“…In this study, we show in human and frog cells that Plk4 interacts with the centrosome protein Cep152, the orthologue of Drosophila melanogaster Asterless. The interaction requires the N-terminal 217 residues of Cep152 and the crypto Polo-box of Plk4. …”
Publicado 2010
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4430por Hall, Rebecca A., De Sordi, Luisa, MacCallum, Donna M., Topal, Hüsnü, Eaton, Rebecca, Bloor, James W., Robinson, Gary K., Levin, Lonny R., Buck, Jochen, Wang, Yue, Gow, Neil A. R., Steegborn, Clemens, Mühlschlegel, Fritz A.“…Comparisons between the Drosophila melanogaster infection model and the mouse model of disseminated candidiasis, suggest that metabolic CO(2) sensing may be important for initial colonisation and epithelial invasion. …”
Publicado 2010
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4431por Jin, Seok Min, Lazarou, Michael, Wang, Chunxin, Kane, Lesley A., Narendra, Derek P., Youle, Richard J.“…It has been found to work in the same pathway as the E3 ligase Parkin in the maintenance of flight muscles and dopaminergic neurons in Drosophila melanogaster and to recruit cytosolic Parkin to mitochondria to mediate mitophagy in mammalian cells. …”
Publicado 2010
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4432“…Here, we analyze the entire set of Drosophila melanogaster nuclearly encoded mitochondrial duplicate genes and show that both RNA- and DNA-mediated mitochondrial gene duplications exhibit an unexpectedly high rate of relocation (change in location between parental and duplicated gene) as well as an extreme tendency to avoid the X chromosome. …”
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4433“…Here we show that 11-cis-vaccenyl acetate (cVA), a male-specific volatile pheromone, robustly promotes male-male aggression in the vinegar fly Drosophila melanogaster. The aggression-promoting effect of synthetic cVA requires olfactory sensory neurons (OSNs) expressing the receptor Or67d4,5,6, as well as the receptor itself. …”
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4434“…In this study, we performed a whole genome RNA interference (RNAi) screen to uncover genes that affect spreading of Drosophila melanogaster S2 cells using several computational methods for analyzing the image data in an automated manner. …”
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4435por Djiane, Alexandre, Shimizu, Hideyuki, Wilkin, Marian, Mazleyrat, Sabine, Jennings, Martin D., Avis, Johanna, Bray, Sarah, Baron, Martin“…Using newly generated null alleles, we demonstrate that polychaetoid (pyd), the unique Drosophila melanogaster ZO homologue, regulates accumulation of adherens junction–localized receptors, such as Notch, although it is dispensable for epithelial polarization. …”
Publicado 2011
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4436“…High-quality TE annotations are available for the Drosophila melanogaster and Arabidopsis thaliana genome sequences, providing a solid basis for the benchmarking of such methods. …”
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4437por Damasco, Christian, Lembo, Antonio, Somma, Maria Patrizia, Gatti, Maurizio, Di Cunto, Ferdinando, Provero, Paolo“…METHODS: We thus constructed a gene expression signature (the DM signature) using the human orthologues of 108 Drosophila melanogaster genes required for either the maintenance of chromosome integrity (36 genes) or mitotic division (72 genes). …”
Publicado 2011
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4438por Molnar, Cristina, Ruiz-Gómez, Ana, Martín, Mercedes, Rojo-Berciano, Susana, Mayor, Federico, de Celis, Jose F.“…The non-visual ß-arrestins are cytosolic proteins highly conserved across species that participate in a variety of signalling events, including plasma membrane receptor degradation, recycling, and signalling, and that can also act as scaffolding for kinases such as MAPK and Akt/PI3K. In Drosophila melanogaster, there is only a single non-visual ß-arrestin, encoded by kurtz, whose function is essential for neuronal activity. …”
Publicado 2011
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4439por Rodal, Avital A., Blunk, Aline D., Akbergenova, Yulia, Jorquera, Ramon A., Buhl, Lauren K., Littleton, J. Troy“…Nwk (Nervous Wreck) is a presynaptic F-BAR/SH3 protein that regulates synaptic growth signaling in Drosophila melanogaster. In this paper, we show that Nwk acts through a physical interaction with sorting nexin 16 (SNX16). …”
Publicado 2011
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4440“…In this study we evaluate the two hypotheses by analyzing patterns of single nucleotide polymorphism in the TFBS of well-characterized CRM in two closely related Drosophila species, Drosophila melanogaster and Drosophila simulans. An important feature of the analysis is classification of TFBS mutations according to the direction of their predicted effect on binding affinity, which allows gains and losses to be evaluated independently along the two phylogenetic lineages. …”
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