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  1. 4621
    “…Telomere integrity in Drosophila melanogaster is maintained by a putative multisubunit complex called terminin that is believed to act in analogy to the mammalian shelterin complex in protecting chromosome ends from being recognized as sites of DNA damage. …”
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    Cross-Species Interaction between Rapidly Evolving Telomere-Specific Drosophila Proteins
  2. 4622
    por Berger, Sandra D., Crook, Sharon M.
    Publicado 2015
    “…In this study, experimentally observed biophysical properties of voltage gated ion channels from the fruitfly Drosophila melanogaster are used to develop a minimal, conductance based neuron model. …”
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    Modeling the Influence of Ion Channels on Neuron Dynamics in Drosophila
  3. 4623
    “…Insulin-like peptide mediated body size plasticity in Drosophila melanogaster has been reported. Here, our studies showed that IIS pathway and nutrition regulate growth and maturation of the male accessory gland (MAG) in the red flour beetle, Tribolium castaneum. …”
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    Nutrition regulation of male accessory gland growth and maturation in Tribolium castaneum
  4. 4624
    “…To test if this phenomenon is conserved in whole organisms, two DSB repair systems were utilized in Drosophila melanogaster. The DR-white and DR-white.mu assays provide a method of measuring DSB repair outcomes between identical and diverged sequences respectively. msh6(–/–) flies, deficient in MMR, were not capable of suppressing recombination between sequences with 1.4% divergence, and the average gene conversion tract length did not differ between msh6(–/+) and msh6(–/–)flies. …”
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    The role of Drosophila mismatch repair in suppressing recombination between diverged sequences
  5. 4625
    por Frazee, Stephen R., Masly, John P.
    Publicado 2015
    “…We genetically modified the size and shape of the posterior lobes of Drosophila melanogaster males and tested the consequences of morphological variation on several reproductive measures. …”
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    Multiple sexual selection pressures drive the rapid evolution of complex morphology in a male secondary genital structure
  6. 4626
    por Wu, Honggang, Manu, Jiao, Renjie, Ma, Jun
    Publicado 2015
    “…Here we generate a data set of the expression profiles of six gap genes in Drosophila melanogaster embryos that differ significantly in size. …”
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    Temporal and spatial dynamics of scaling-specific features of a gene regulatory network in Drosophila
  7. 4627
    “…We transfected a Drosophila melanogaster library into S2 cells in normoxia and hypoxia, and assayed 4,599,881 genomic DNA fragments in parallel. …”
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    Genome-wide identification of hypoxia-induced enhancer regions
  8. 4628
    “…Mutually exclusive splicing is an important means of increasing the protein repertoire, by which the Down's syndrome cell adhesion molecule (Dscam) gene potentially generates 38,016 different isoforms in Drosophila melanogaster. However, the regulatory mechanisms remain obscure due to the complexity of the Dscam exon cluster. …”
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    Long-range RNA pairings contribute to mutually exclusive splicing
  9. 4629
    “…The Hippo pathway was initially identified in Drosophila melanogaster screens for tissue growth two decades ago and has been a subject extensively studied in both Drosophila and mammals in the last several years. …”
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    Mechanisms of Hippo pathway regulation
  10. 4630
    “…The database encompasses 138 insect genomes, 116 insect transcriptomes, 61 insect gene sets, 36 gene families of 60 insects, 7544 miRNAs of 69 insects, 96 925 piRNAs of Drosophila melanogaster and Chilo suppressalis, 2439 lncRNA of Nilaparvata lugens, 22 536 pathways of 78 insects, 678 881 untranslated regions (UTR) of 84 insects and 160 905 coding sequences (CDS) of 70 insects. …”
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    InsectBase: a resource for insect genomes and transcriptomes
  11. 4631
    “…Additionally, the structural models have been expanded to include an extra model organism (Drosophila melanogaster). We also document a number of additional visualization tools in the Gene3D website.…”
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    Gene3D: expanding the utility of domain assignments
  12. 4632
    “…The interface between relay and converter domain of muscle myosin is critical for optimal myosin performance. Using Drosophila melanogaster indirect flight muscle S1, we performed a kinetic analysis of the effect of mutations in the converter and relay domain. …”
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    The Relay/Converter Interface Influences Hydrolysis of ATP by Skeletal Muscle Myosin II
  13. 4633
    “…Using the simple Drosophila melanogaster larval model to study this relationship we identify an unexpected phenomenon: response to an attractant can be selectively blocked by previous exposure to some odorants that activates the same receptor. …”
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    Short-term memory trace mediated by termination kinetics of olfactory receptor
  14. 4634
    “…Libraries of transgenic Drosophila melanogaster carrying RNA interference (RNAi) constructs have been used extensively to perform large-scale functional genetic screens in vivo. …”
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    A Drosophila RNAi library modulates Hippo pathway-dependent tissue growth
  15. 4635
    “…Our analysis examines the conservation of multiprotein complexes among metazoa through use of high resolution biochemical fractionation and precision mass spectrometry applied to soluble cell extracts from 5 representative model organisms Caenorhabditis elegans, Drosophila melanogaster, Mus musculus, Strongylocentrotus purpuratus, and Homo sapiens. …”
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    Proteome-wide dataset supporting the study of ancient metazoan macromolecular complexes
  16. 4636
    “…In the fruit fly Drosophila melanogaster, which shows a robust diurnal pattern of sleep/wake activity, caffeine reduces nighttime sleep behavior independently of the one known adenosine receptor. …”
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    Caffeine promotes wakefulness via dopamine signaling in Drosophila
  17. 4637
    “…Here, we investigate the effects of epigenetic information on gene sequence evolution in two disparate insects: the fly Drosophila melanogaster, which lacks substantial DNA methylation, and the ant Camponotus floridanus, which possesses a functional DNA methylation system. …”
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    Effects of DNA Methylation and Chromatin State on Rates of Molecular Evolution in Insects
  18. 4638
    “…Here, we compared the capacity of all Drosophila melanogaster small HSP family members for their ability to assist in refolding stress‐denatured substrates and/or to prevent aggregation of disease‐associated misfolded proteins. …”
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    Specific protein homeostatic functions of small heat‐shock proteins increase lifespan
  19. 4639
    “…Here we identify two phases of sensitivity to larval nutrition that contribute to plasticity in ovariole number, an important determinant of fecundity, in Drosophila melanogaster. These two phases of sensitivity are separated by the developmental checkpoint called “critical weight”; poor nutrition has greater effects on ovariole number in larvae before critical weight than after. …”
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    Stage-Specific Plasticity in Ovary Size Is Regulated by Insulin/Insulin-Like Growth Factor and Ecdysone Signaling in Drosophila
  20. 4640
    “…In a classic example of the invasion of a species by a selfish genetic element, the P-element was horizontally transferred from a distantly related species into Drosophila melanogaster. Despite causing ‘hybrid dysgenesis’, a syndrome of abnormal phenotypes that include sterility, the P-element spread globally in the course of a few decades in D. melanogaster. …”
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    Hybrid Dysgenesis in Drosophila simulans Associated with a Rapid Invasion of the P-Element
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