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  1. 4841
    por Bono, Hidemasa
    Publicado 2021
    “…Only RNA-seq data of Drosophila melanogaster were found and were systematically analyzed using a newly developed RNA-seq analysis workflow for species without a reference genome sequence. …”
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    Meta-Analysis of Oxidative Transcriptomes in Insects
  2. 4842
    “…Here, we report a comprehensive, tissue-specific investigation of Drosophila melanogaster FRT gene expression before and after mating. …”
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    Drosophila female reproductive tract gene expression reveals coordinated mating responses and rapidly evolving tissue-specific genes
  3. 4843
    “…In conclusion, catalytically inactive forms of Prx-SO(2/3) serve not only as a marker of cellular oxidative burden, but may also play a role in an adaptive response, leading to a positive effect on the physiology of Drosophila melanogaster.…”
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    Hyperoxidation of Peroxiredoxins and Effects on Physiology of Drosophila
  4. 4844
    “…Some RIG-I-like receptors (RLRs) discriminate viral and cellular dsRNA by their termini, and Drosophila melanogaster Dicer-2 (dmDcr-2) differentially processes dsRNA with blunt or 2 nucleotide 3’-overhanging termini. …”
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    Transient kinetic studies of the antiviral Drosophila Dicer-2 reveal roles of ATP in self–nonself discrimination
  5. 4845
    “…Here, we use an automated closed-loop optogenetic activation screen to detect novel taste and feeding neurons in Drosophila melanogaster. Out of 122 Janelia FlyLight Project GAL4 lines preselected based on expression pattern, we identify six lines that acutely promote feeding and 35 lines that inhibit it. …”
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    A closed-loop optogenetic screen for neurons controlling feeding in Drosophila
  6. 4846
    “…In this issue of BMC Biology, Holland et al. report an approach where food sources with different isotope labeled carbon ratios can be used to answer this question, and find that tumors arising in Drosophila melanogaster procure most of their nutrients from the host.…”
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    The CAT-SIR is out of the bag: tumors prefer host rather than dietary nutrients
  7. 4847
    “…Here we exploit midgut morphogenesis in Drosophila melanogaster to investigate the mechanisms underlying MET. …”
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    Mesenchymal-to-epithelial transitions require tissue-specific interactions with distinct laminins
  8. 4848
    “…In the fruit fly Drosophila melanogaster, dopaminergic reinforcement has largely been studied using genetics, whereas pharmacological approaches have received less attention. …”
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    Associative learning in larval and adult Drosophila is impaired by the dopamine-synthesis inhibitor 3-Iodo-L-tyrosine
  9. 4849
    “…We show that two neuronally enriched and highly conserved microRNAs, miR-125 and let-7 mediate the DR response in Drosophila melanogaster. Functional characterization of miR-125 demonstrates its role in neurons while its target chinmo acts both in neurons and the fat body to modulate fat metabolism and longevity. …”
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    miR-125-chinmo pathway regulates dietary restriction-dependent enhancement of lifespan in Drosophila
  10. 4850
    “…This study investigated the effect of ethanol-extracted green lettuce leaf (GLE) on sleep behavior in physical stress-induced invertebrate and vertebrate models. In Drosophila melanogaster, the group that experienced vibration stress showed decreased sleep time compared to the no-vibration-stress control group, but the GLE treatment group recovered this lost sleep time. …”
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    Effects of Green Lettuce Leaf Extract on Sleep Disturbance Control in Oxidative Stress-Induced Invertebrate and Vertebrate Models
  11. 4851
    “…To advance our understanding of adaptation to temporally varying selection pressures, we identified signatures of seasonal adaptation occurring in parallel among Drosophila melanogaster populations. Specifically, we estimated allele frequencies genome-wide from flies sampled early and late in the growing season from 20 widely dispersed populations. …”
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    Broad geographic sampling reveals the shared basis and environmental correlates of seasonal adaptation in Drosophila
  12. 4852
    “…However, the cellular processes taking place remain unclear. Drosophila melanogaster is an emerging neurodegeneration model due to its versatility as a tool for genetic studies. …”
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    Cell competition from development to neurodegeneration
  13. 4853
    “…As a result, much of what we know about the development of neural circuits is derived from work in crustaceans, nematode worms and arguably most of all, the fruit fly, Drosophila melanogaster. This review aims to demonstrate the utility of the Drosophila larval locomotor network as a model circuit, to those who do not usually use the fly in their work. …”
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    The Drosophila Larval Locomotor Circuit Provides a Model to Understand Neural Circuit Development and Function
  14. 4854
    “…Three-dimensional eukaryotic genome organization provides the structural basis for gene regulation. In Drosophila melanogaster, genome folding is characterized by somatic homolog pairing, where homologous chromosomes are intimately paired from end to end; however, how homologs identify one another and pair has remained mysterious. …”
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    Live imaging and biophysical modeling support a button-based mechanism of somatic homolog pairing in Drosophila
  15. 4855
    “…The hemibrain connectome provides large-scale connectivity and morphology information for the majority of the central brain of Drosophila melanogaster. Using this data set, we provide a complete description of the Drosophila olfactory system, covering all first, second and lateral horn-associated third-order neurons. …”
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    Information flow, cell types and stereotypy in a full olfactory connectome
  16. 4856
    “…In this study, we used Drosophila melanogaster to investigate the consequences of neuronal knockdown of swiss cheese (sws)—the evolutionarily conserved ortholog of human NTE/PNPLA6—in vivo. …”
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    Loss of swiss cheese in Neurons Contributes to Neurodegeneration with Mitochondria Abnormalities, Reactive Oxygen Species Acceleration and Accumulation of Lipid Droplets in Drosophila Brain
  17. 4857
    “…Here, we show that X-ray holographic nano-tomography (XNH) can image millimeter-scale volumes with sub-100 nm resolution, enabling reconstruction of dense wiring in Drosophila melanogaster and mouse nervous tissue. We performed correlative XNH and EM to reconstruct hundreds of cortical pyramidal cells, and show that more superficial cells receive stronger synaptic inhibition on their apical dendrites. …”
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    Dense neuronal reconstruction through X-ray holographic nano-tomography
  18. 4858
    por Hajirnis, Nikhil, Mishra, Rakesh K.
    Publicado 2021
    “…Further, we revisit their discovery and regulation in Drosophila melanogaster. We also review their regulation in different arthropods and vertebrates, with a significant focus on Hox expression in the crustacean Parahyale hawaiensis. …”
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    Homeotic Genes: Clustering, Modularity, and Diversity
  19. 4859
    “…The fruit fly Drosophila melanogaster has a fast reproduction time, powerful genetics, and facilitates large sample sizes, making it a strong model of seizure mechanisms. …”
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    Characterization of Seizure Induction Methods in Drosophila
  20. 4860
    “…We examine the impact of 420nm exposure on drosophila melanogaster mitochondria and its impact on fly mobility. …”
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    Mitochondria are specifically vulnerable to 420nm light in drosophila which undermines their function and is associated with reduced fly mobility
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