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5141“…Both the core JAK-STAT pathway components and their in vivo roles have been widely conserved between vertebrates and invertebrate models such as Drosophila melanogaster. Misregulation of JAK-STAT pathway activity has also been identified as a key factor in the development of multiple human malignancies. …”
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5142“…We show that many Drosophila melanogaster testis-specific mRNAs require Nxt1 for their accumulation. …”
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5143“…By mapping millions of restriction site–flanking reads back to the Escherichia coli and Drosophila melanogaster genomes we were able to quantitatively characterize the cognate and star site activity of EcoRI and MfeI and demonstrate genome-wide decreases in star activity with engineered high-fidelity variants EcoRI-HF and MfeI-HF, as well as quantify the influence on MfeI cleavage conferred by flanking nucleotides. …”
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5144“…Primordial germ cell (PGC) formation in holometabolous insects like Drosophila melanogaster relies on maternally synthesised germ cell determinants that are asymmetrically localised to the oocyte posterior cortex. …”
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5145por Caragata, Eric P., Rancès, Edwige, Hedges, Lauren M., Gofton, Alexander W., Johnson, Karyn N., O'Neill, Scott L., McGraw, Elizabeth A.“…Here we have examined the involvement of cholesterol in pathogen blocking using a system of dietary manipulation in Drosophila melanogaster in combination with challenge by Drosophila C virus (DCV), a common fly pathogen. …”
Publicado 2013
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5146por Knævelsrud, Helene, Søreng, Kristiane, Raiborg, Camilla, Håberg, Karin, Rasmuson, Fredrik, Brech, Andreas, Liestøl, Knut, Rusten, Tor Erik, Stenmark, Harald, Neufeld, Thomas P., Carlsson, Sven R., Simonsen, Anne“…The PX-BAR protein SNX18 was identified as a positive regulator of autophagosome formation, and its Drosophila melanogaster homologue SH3PX1 was found to be required for efficient autophagosome formation in the larval fat body. …”
Publicado 2013
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5147por Huang, Hong-Ling, Wang, Shimin, Yin, Meng-Xin, Dong, Liang, Wang, Chao, Wu, Wei, Lu, Yi, Feng, Miao, Dai, Chuanyang, Guo, Xiaocan, Li, Li, Zhao, Bin, Zhou, Zhaocai, Ji, Hongbin, Jiang, Jin, Zhao, Yun, Liu, Xin-Yuan, Zhang, Lei“…Here, we reported the identification of Par-1 as a regulator of the Hpo signaling pathway using a gain-of-function EP screen in Drosophila melanogaster. Overexpression of Par-1 elevated Yorkie activity, resulting in increased Hpo target gene expression and tissue overgrowth, while loss of Par-1 diminished Hpo target gene expression and reduced organ size. …”
Publicado 2013
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5148por Staubach, Fabian, Baines, John F., Künzel, Sven, Bik, Elisabeth M., Petrov, Dmitri A.“…In order to specifically investigate effects of food source and host species on bacterial communities, we analyzed samples from wild Drosophila melanogaster and D. simulans collected from a variety of natural substrates, as well as from adults and larvae of nine laboratory-reared Drosophila species. …”
Publicado 2013
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5149“…This is the first report of a systematic analysis using Drosophila melanogaster hemocytes to study adhesion-related proteins and their function in cell migration in vivo. …”
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5150por Matkovic, Tanja, Siebert, Matthias, Knoche, Elena, Depner, Harald, Mertel, Sara, Owald, David, Schmidt, Manuela, Thomas, Ulrich, Sickmann, Albert, Kamin, Dirk, Hell, Stefan W., Bürger, Jörg, Hollmann, Christina, Mielke, Thorsten, Wichmann, Carolin, Sigrist, Stephan J.“…We showed previously that loss of the Drosophila melanogaster ELKS family protein Bruchpilot (BRP) eliminates the cytomatrix (T bar) and declusters Ca(2+) channels. …”
Publicado 2013
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5151“…The search is genome wide, with the restriction that only alignments that correspond to euchromatic regions, which consist of at least 10 Drosophila species, are being considered (59% of the euchromatic genome of Drosophila melanogaster). We find that long-range covariations are especially prevalent between exons of mRNAs as well as noncoding RNAs; the majority of the observed covariations appear as not reverse complementary, but as synchronized mutations, which could be due to interactions with common interaction partners or due to the involvement of genomic elements that are antisense of annotated transcripts. …”
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5152por Atkins, Mardelle, Jiang, Yuwei, Sansores-Garcia, Leticia, Jusiak, Barbara, Halder, Georg, Mardon, Graeme“…Eye development in the fruit fly Drosophila melanogaster is driven by the highly conserved selector gene network referred to as the “retinal determination gene network,” composed of approximately 20 factors, whose core comprises twin of eyeless (toy), eyeless (ey), sine oculis (so), dachshund (dac), and eyes absent (eya). …”
Publicado 2013
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5153por Smith, Helen F., Roberts, Meredith A., Nguyen, Huy Q., Peterson, Maureen, Hartl, Tom A., Wang, Xiao-Jun, Klebba, Joseph E., Rogers, Gregory C., Bosco, Giovanni“…To better understand how Drosophila melanogaster condensin is regulated, we performed a yeast two-hybrid screen and identified the chromo-barrel domain protein Mrg15 to interact with the Cap-H2 condensin subunit. …”
Publicado 2013
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5154“…Here, we study the evolution of microRNA clusters in Drosophila melanogaster. We observed that the majority of microRNA clusters arose by the de novo formation of new microRNA-like hairpins in existing microRNA transcripts. …”
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5155por Fontenele, Marcio, Lim, Bomyi, Oliveira, Danielle, Buffolo, Márcio, Perlman, David H., Schupbach, Trudi, Araujo, Helena“…We investigate the action of Calpain A (CalpA) on the Drosophila melanogaster IκB homologue Cactus in vivo. CalpA alters the absolute amounts of Cactus protein. …”
Publicado 2013
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5156“…The cellular and molecular bases of flight neuromodulatory circuits are not well defined. In Drosophila melanogaster, it is known that neuronal IP(3) receptor mediated Ca(2+) signaling and store-operated Ca(2+) entry (SOCE) are required for air-puff stimulated adult flight. …”
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5157por Tan, Cedric K. W., Løvlie, Hanne, Greenway, Elisabeth, Goodwin, Stephen F., Pizzari, Tommaso, Wigby, Stuart“…Here, we show that male and female Drosophila melanogaster respond to the direct and phenotypic sexual familiarity of potential mates in fundamentally different ways. …”
Publicado 2013
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5158por Lalle, Marco, Leptourgidou, Flora, Camerini, Serena, Pozio, Edoardo, Skoulakis, Efthimios M. C.“…We use inter-kingdom reciprocal functional complementation and biochemical methods to determine whether g14-3-3 is structurally and functionally homologous with members of the two 14-3-3 conservation groups of the metazoan Drosophila melanogaster. Our results indicate that although g14-3-3 is structurally homologous to D14-3-3ε, functionally it diverges presenting characteristics of other 14-3-3s. …”
Publicado 2013
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5159“…We find that temperature strongly modifies the pleiotropic phenotypic effects of an incompatible interaction between a Drosophila melanogaster polymorphism in the nuclear-encoded, mitochondrial tyrosyl-transfer (t)RNA synthetase and a D. simulans polymorphism in the mitochondrially encoded tRNA(Tyr). …”
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5160por Zhong, Weihao, McClure, Colin D., Evans, Cara R., Mlynski, David T., Immonen, Elina, Ritchie, Michael G., Priest, Nicholas K.“…It has recently been shown that female fruitflies, Drosophila melanogaster, specifically upregulate two members of the Turandot family of immune and stress response genes, Turandot M and Turandot C (TotM and TotC), when they hear male courtship song. …”
Publicado 2013
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