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  1. 5361
    “…In this study, we modulated the dosage of fission and fusion genes in a Drosophila melanogaster loss-of-function model and found that mitochondrial fragmentation and disease phenotypes were rescued by reduced Drp1. …”
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    CCP1 promotes mitochondrial fusion and motility to prevent Purkinje cell neuron loss in pcd mice
  2. 5362
    “…Curiously, although Drosophila melanogaster feed on yeast that produce CO(2) and ethanol during fermentation, laboratory experiments suggest that walking flies avoid CO(2)(7–12). …”
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    Distinct activity-gated pathways mediate attraction and aversion to CO(2) in Drosophila
  3. 5363
    “…Insecticidal activity was assessed by topical application to Anopheles gambiae adult mosquitoes, paralysis in a headless larval assay, at the cellular level with patch-clamp recordings of engineered HEK cells expressing AgKv2.1 channels, as well as central nervous system recordings from larval Drosophila melanogaster. With only one hydroxyl group difference, decanoic acid had a consistently greater effect than 5-HDC in blocking Kv channels, paralyzing larvae, and killing mosquitoes. …”
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    Fatty Acid and Related Potassium Kv2 Channel Blockers: Toxicity and Physiological Actions on Mosquitoes
  4. 5364
    “…FlyBase (flybase.org) is a knowledge base that supports the community of researchers that use the fruit fly, Drosophila melanogaster, as a model organism. The FlyBase team curates and organizes a diverse array of genetic, molecular, genomic, and developmental information about Drosophila. …”
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    FlyBase 2.0: the next generation
  5. 5365
    “…The western corn rootworm (WCR, Diabrotica virgifera virgifera) gene, dvssj1, is a putative homolog of the Drosophila melanogaster gene, snakeskin (ssk). This gene encodes a membrane protein associated with the smooth septate junction (SSJ) which is required for the proper barrier function of the epithelial lining of insect intestines. …”
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    Molecular characterization of the insecticidal activity of double-stranded RNA targeting the smooth septate junction of western corn rootworm (Diabrotica virgifera virgifera)
  6. 5366
    “…Understanding the circuit mechanisms behind motion detection is a long-standing question in visual neuroscience. In Drosophila melanogaster, recently discovered synapse-level connectomes in the optic lobe, particularly in ON-pathway (T4) receptive-field circuits, in concert with physiological studies, suggest a motion model that is increasingly intricate when compared with the ubiquitous Hassenstein-Reichardt model. …”
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    Comparisons between the ON- and OFF-edge motion pathways in the Drosophila brain
  7. 5367
    “…We investigated the influence of the parent-of-origin's diet on adult progeny phenotypes and reproductive output for three generations in fruit flies (Drosophila melanogaster). Males and females reared on a control diet were exposed to the control diet or one of two altered (no- or high-) sugar treatment diets for a single generation. …”
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    Ancestral diet transgenerationally influences offspring in a parent-of-origin and sex-specific manner
  8. 5368
    “…In this study, the utility of transcriptome data for phenotype prediction was tested with 185 inbred lines of Drosophila melanogaster for nine traits in two sexes. We incorporated the transcriptome data into genomic prediction via two methods: GTBLUP and GRBLUP, both combining single nucleotide polymorphisms (SNPs) and transcriptome data. …”
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    Integrating Gene Expression Data Into Genomic Prediction
  9. 5369
    “…While the development of rhabdomeric PRs has been thoroughly studied in the fruit fly Drosophila melanogaster, we still know very little about how they form in other species. …”
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    Glass confers rhabdomeric photoreceptor identity in Drosophila, but not across all metazoans
  10. 5370
    “…The very C-terminal region of Bruchpilot (Brp), a key component of the Drosophila melanogaster CAZ, participates in SV tethering. …”
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    Complexin cooperates with Bruchpilot to tether synaptic vesicles to the active zone cytomatrix
  11. 5371
    “…Using here the pathogen-blocking Wolbachia strain from Drosophila melanogaster, introduced into two different Drosophila cell lines, we show that Wolbachia subvert the endoplasmic reticulum to acquire their vacuolar membrane and colonize the host cell at high density. …”
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    Wolbachia endosymbionts subvert the endoplasmic reticulum to acquire host membranes without triggering ER stress
  12. 5372
    “…Here we introduce larval Drosophila melanogaster as a relatively simple study case for such one-trial learning. …”
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    One-trial learning in larval Drosophila
  13. 5373
    “…Here we test this hypothesis by applying bidirectional selection to male mating success for 14 generations in replicate populations of Drosophila melanogaster. We then resequenced the genomes of flies from each population. …”
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    Molecular evidence supports a genic capture resolution of the lek paradox
  14. 5374
    “…A genetic model of glioma in Drosophila melanogaster and mice with GBM patients-derived orthotopic xenografts were used as in vivo models of disease. …”
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    Specific V-ATPase expression sub-classifies IDHwt lower-grade gliomas and impacts glioma growth in vivo
  15. 5375
    “…Most immune related pathways were identified and characterized in holometabolous insects such as Drosophila melanogaster, and it was assumed they would be highly conserved in all insects. …”
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    Rhodnius prolixus: Identification of missing components of the IMD immune signaling pathway and functional characterization of its role in eliminating bacteria
  16. 5376
    “…As a proof-of-principle, we applied VDTS to NMR spectra of polar metabolites in the hemolymph (blood) of the tiny yet powerful genetic model Drosophila melanogaster. This showed that VDTS calculation of absolute metabolite concentrations in fed versus starved Drosophila larvae is more accurate than methods utilizing normalization to total spectral signal. …”
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    An Improved Method for Measuring Absolute Metabolite Concentrations in Small Biofluid or Tissue Samples
  17. 5377
    “…Genetic model organisms, such as Drosophila melanogaster, can help identifying evolutionary conserved mechanisms underlying aging. …”
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    Longitudinal assessment of health-span and pre-death morbidity in wild type Drosophila
  18. 5378
    por Bongartz, Philipp
    Publicado 2019
    “…RESULTS: We propose novel repeat resolution methods for large interspersed repeat families and assess their accuracy on simulated data sets with various distinct repeat structures and on drosophila melanogaster transposons. Additionally, we compare our methods to an existing long read repeat resolution tool and show the improved accuracy of our method. …”
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    Resolving repeat families with long reads
  19. 5379
    “…We also found that T. mercedesae IR25a and IR93a were capable of rescuing temperature and humidity preference defects in Drosophila melanogaster IR25a and IR93a mutants. These results demonstrate that the structures and physiological functions of ancient IRs have been conserved during arthropod evolution. …”
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    Honey Bee Parasitic Mite Contains the Sensilla-Rich Sensory Organ on the Foreleg Tarsus Expressing Ionotropic Receptors With Conserved Functions
  20. 5380
    “…Herein, we focused on Sex-lethal (Sxl), which is the master sex-determination gene in Drosophila melanogaster and is necessary for female germline development. …”
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    Dimorphic sperm formation by Sex-lethal
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