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5361por Gilmore-Hall, Stephen, Kuo, Jennifer, Ward, Jacqueline M., Zahra, Rabaab, Morrison, Richard S., Perkins, Guy, La Spada, Albert R.“…In this study, we modulated the dosage of fission and fusion genes in a Drosophila melanogaster loss-of-function model and found that mitochondrial fragmentation and disease phenotypes were rescued by reduced Drp1. …”
Publicado 2019
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5362“…Curiously, although Drosophila melanogaster feed on yeast that produce CO(2) and ethanol during fermentation, laboratory experiments suggest that walking flies avoid CO(2)(7–12). …”
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5363por Démares, Fabien, Coquerel, Quentin, Richoux, Gary, Linthicum, Kenneth, Bloomquist, Jeffrey“…Insecticidal activity was assessed by topical application to Anopheles gambiae adult mosquitoes, paralysis in a headless larval assay, at the cellular level with patch-clamp recordings of engineered HEK cells expressing AgKv2.1 channels, as well as central nervous system recordings from larval Drosophila melanogaster. With only one hydroxyl group difference, decanoic acid had a consistently greater effect than 5-HDC in blocking Kv channels, paralyzing larvae, and killing mosquitoes. …”
Publicado 2018
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5364por Thurmond, Jim, Goodman, Joshua L, Strelets, Victor B, Attrill, Helen, Gramates, L Sian, Marygold, Steven J, Matthews, Beverley B, Millburn, Gillian, Antonazzo, Giulia, Trovisco, Vitor, Kaufman, Thomas C, Calvi, Brian R“…FlyBase (flybase.org) is a knowledge base that supports the community of researchers that use the fruit fly, Drosophila melanogaster, as a model organism. The FlyBase team curates and organizes a diverse array of genetic, molecular, genomic, and developmental information about Drosophila. …”
Publicado 2019
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5365por Hu, Xu, Steimel, Joseph P., Kapka-Kitzman, Deirdre M., Davis-Vogel, Courtney, Richtman, Nina M., Mathis, John P., Nelson, Mark E., Lu, Albert L., Wu, Gusui“…The western corn rootworm (WCR, Diabrotica virgifera virgifera) gene, dvssj1, is a putative homolog of the Drosophila melanogaster gene, snakeskin (ssk). This gene encodes a membrane protein associated with the smooth septate junction (SSJ) which is required for the proper barrier function of the epithelial lining of insect intestines. …”
Publicado 2019
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5366por Shinomiya, Kazunori, Huang, Gary, Lu, Zhiyuan, Parag, Toufiq, Xu, C Shan, Aniceto, Roxanne, Ansari, Namra, Cheatham, Natasha, Lauchie, Shirley, Neace, Erika, Ogundeyi, Omotara, Ordish, Christopher, Peel, David, Shinomiya, Aya, Smith, Claire, Takemura, Satoko, Talebi, Iris, Rivlin, Patricia K, Nern, Aljoscha, Scheffer, Louis K, Plaza, Stephen M, Meinertzhagen, Ian A“…Understanding the circuit mechanisms behind motion detection is a long-standing question in visual neuroscience. In Drosophila melanogaster, recently discovered synapse-level connectomes in the optic lobe, particularly in ON-pathway (T4) receptive-field circuits, in concert with physiological studies, suggest a motion model that is increasingly intricate when compared with the ubiquitous Hassenstein-Reichardt model. …”
Publicado 2019
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5367“…We investigated the influence of the parent-of-origin's diet on adult progeny phenotypes and reproductive output for three generations in fruit flies (Drosophila melanogaster). Males and females reared on a control diet were exposed to the control diet or one of two altered (no- or high-) sugar treatment diets for a single generation. …”
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5368“…In this study, the utility of transcriptome data for phenotype prediction was tested with 185 inbred lines of Drosophila melanogaster for nine traits in two sexes. We incorporated the transcriptome data into genomic prediction via two methods: GTBLUP and GRBLUP, both combining single nucleotide polymorphisms (SNPs) and transcriptome data. …”
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5369“…While the development of rhabdomeric PRs has been thoroughly studied in the fruit fly Drosophila melanogaster, we still know very little about how they form in other species. …”
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5370por Scholz, Nicole, Ehmann, Nadine, Sachidanandan, Divya, Imig, Cordelia, Cooper, Benjamin H., Jahn, Olaf, Reim, Kerstin, Brose, Nils, Meyer, Jutta, Lamberty, Marius, Altrichter, Steffen, Bormann, Anne, Hallermann, Stefan, Pauli, Martin, Heckmann, Manfred, Stigloher, Christian, Langenhan, Tobias, Kittel, Robert J.“…The very C-terminal region of Bruchpilot (Brp), a key component of the Drosophila melanogaster CAZ, participates in SV tethering. …”
Publicado 2019
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5371“…Using here the pathogen-blocking Wolbachia strain from Drosophila melanogaster, introduced into two different Drosophila cell lines, we show that Wolbachia subvert the endoplasmic reticulum to acquire their vacuolar membrane and colonize the host cell at high density. …”
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5372por Weiglein, Aliće, Gerstner, Florian, Mancini, Nino, Schleyer, Michael, Gerber, Bertram“…Here we introduce larval Drosophila melanogaster as a relatively simple study case for such one-trial learning. …”
Publicado 2019
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5373“…Here we test this hypothesis by applying bidirectional selection to male mating success for 14 generations in replicate populations of Drosophila melanogaster. We then resequenced the genomes of flies from each population. …”
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5374por Terrasi, Andrea, Bertolini, Irene, Martelli, Cristina, Gaudioso, Gabriella, Di Cristofori, Andrea, Storaci, Alessandra Maria, Formica, Miriam, Bosari, Silvano, Caroli, Manuela, Ottobrini, Luisa, Vaccari, Thomas, Vaira, Valentina“…A genetic model of glioma in Drosophila melanogaster and mice with GBM patients-derived orthotopic xenografts were used as in vivo models of disease. …”
Publicado 2019
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5375por Salcedo-Porras, Nicolas, Guarneri, Alessandra, Oliveira, Pedro L., Lowenberger, Carl“…Most immune related pathways were identified and characterized in holometabolous insects such as Drosophila melanogaster, and it was assumed they would be highly conserved in all insects. …”
Publicado 2019
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5376por Fernando, Tharindu, Sawala, Annick, Bailey, Andrew P., Gould, Alex P., Driscoll, Paul C.“…As a proof-of-principle, we applied VDTS to NMR spectra of polar metabolites in the hemolymph (blood) of the tiny yet powerful genetic model Drosophila melanogaster. This showed that VDTS calculation of absolute metabolite concentrations in fed versus starved Drosophila larvae is more accurate than methods utilizing normalization to total spectral signal. …”
Publicado 2019
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5377por Gaitanidis, Alexandros, Dimitriadou, Agapi, Dowse, Harold, Sanyal, Subhabrata, Duch, Carsten, Consoulas, Christos“…Genetic model organisms, such as Drosophila melanogaster, can help identifying evolutionary conserved mechanisms underlying aging. …”
Publicado 2019
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5378por Bongartz, Philipp“…RESULTS: We propose novel repeat resolution methods for large interspersed repeat families and assess their accuracy on simulated data sets with various distinct repeat structures and on drosophila melanogaster transposons. Additionally, we compare our methods to an existing long read repeat resolution tool and show the improved accuracy of our method. …”
Publicado 2019
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5379“…We also found that T. mercedesae IR25a and IR93a were capable of rescuing temperature and humidity preference defects in Drosophila melanogaster IR25a and IR93a mutants. These results demonstrate that the structures and physiological functions of ancient IRs have been conserved during arthropod evolution. …”
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5380por Sakai, Hiroki, Oshima, Hiroyuki, Yuri, Kodai, Gotoh, Hiroki, Daimon, Takaaki, Yaginuma, Toshinobu, Sahara, Ken, Niimi, Teruyuki“…Herein, we focused on Sex-lethal (Sxl), which is the master sex-determination gene in Drosophila melanogaster and is necessary for female germline development. …”
Publicado 2019
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