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5681“…Overexpression of an exogenous RpS9 copy in Drosophila melanogaster S2 cells induced alternative splicing and degradation of the endogenous copy by nonsense-mediated decay (NMD). …”
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5682por Akif, Mohd, Masuyer, Geoffrey, Schwager, Sylva L U, Bhuyan, Bhaskar J, Mugesh, Govindasamy, Isaac, R Elwyn, Sturrock, Edward D, Acharya, K Ravi“…Here, we report the crystal structures of human testis ACE (tACE) and a homologue of ACE, known as AnCE, from Drosophila melanogaster in complex with the most promising selenium analogue of captopril (SeCap) determined at 2.4 and 2.35 Å resolution, respectively. …”
Publicado 2011
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5683“…YY1 is the mammalian orthologue of Pleiohomeotic, one of the transcription factors that binds Polycomb DNA response elements in Drosophila melanogaster and mediates Polycomb group proteins (PcG) recruitment to DNA. …”
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5684por Ladoukakis, Emmanuel, Pereira, Vini, Magny, Emile G, Eyre-Walker, Adam, Couso, Juan Pablo“…RESULTS: Using bio-informatics methods, we have searched for smORFs of less than 100 amino acids in the putatively non-coding euchromatic DNA of Drosophila melanogaster, and initially identified nearly 600,000 of them. …”
Publicado 2011
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5685por Gladstone, Mara, Frederick, Barbara, Zheng, Di, Edwards, Anthony, Yoon, Petros, Stickel, Stefanie, DeLaney, Tessie, Chan, Daniel C., Raben, David, Su, Tin Tin“…We described previously a screening protocol in Drosophila melanogaster that allows us to identify small molecules that increase the killing effect of ionizing radiation in vivo in a multicellular context. …”
Publicado 2012
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5686“…We have uncovered a novel link between dietary factors and sleep behavior in Drosophila melanogaster. Dietary sugar rapidly altered sleep behavior by modulating the number of sleep episodes during both the light and dark phase of the circadian period, independent of an intact circadian rhythm and without affecting total sleep, latency to sleep, or waking activity. …”
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5687por Ali, Sameh S., Hsiao, Mary, Zhao, Huiwen W., Dugan, Laura L., Haddad, Gabriel G., Zhou, Dan“…Through long-term laboratory selection, we have generated a Drosophila melanogaster population that tolerates severe, normally lethal, level of hypoxia. …”
Publicado 2012
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5688“…Here we address the division frequency of Germline Stem Cells (GSCs) in testes of Drosophila melanogaster. We show that GSC division frequency is under genetic control of the highly conserved Epidermal Growth Factor (EGF) signaling pathway. …”
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5689“…An extreme example of somatic pairing can be observed in Drosophila melanogaster, where homologous chromosomes remain aligned throughout most of development. …”
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5690por Robinson, Brooks G., Khurana, Sukant, Pohl, Jascha B., Li, Wen-ke, Ghezzi, Alfredo, Cady, Amanda M., Najjar, Kristina, Hatch, Michael M., Shah, Ruchita R., Bhat, Amar, Hariri, Omar, Haroun, Kareem B., Young, Melvin C., Fife, Kathryn, Hooten, Jeff, Tran, Tuan, Goan, Daniel, Desai, Foram, Husain, Farhan, Godinez, Ryan M., Sun, Jeffrey C., Corpuz, Jonathan, Moran, Jacxelyn, Zhong, Allen C., Chen, William Y., Atkinson, Nigel S.“…Drosophila melanogaster has proven to be a useful model system for the genetic analysis of ethanol-associated behaviors. …”
Publicado 2012
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5691por Speretta, Elena, Jahn, Thomas R., Tartaglia, Gian Gaetano, Favrin, Giorgio, Barros, Teresa P., Imarisio, Sara, Lomas, David A., Luheshi, Leila M., Crowther, Damian C., Dobson, Christopher M.“…We have designed a series of tandem dimeric constructs of these Aβ peptides to probe the manner in which changes in the aggregation kinetics of Aβ affect its deposition and toxicity in a Drosophila melanogaster model system. The levels of insoluble aggregates were found to be substantially elevated in flies expressing the tandem constructs of both Aβ(40) and Aβ(42) compared with the equivalent monomeric peptides, consistent with the higher effective concentration, and hence increased aggregation rate, of the peptides in the tandem repeat. …”
Publicado 2012
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5692“…The mir-2 microRNA family is the largest in Drosophila melanogaster, with 8 members that are mostly clustered in the genome. …”
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5693“…In Drosophila melanogaster, cis-regulatory modules that are activated by the Notch cell–cell signaling pathway all contain two types of transcription factor binding sites: those for the pathway's transducing factor Suppressor of Hairless [Su(H)] and those for one or more tissue- or cell type–specific factors called “local activators.” …”
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5694por Coen, Katrijn, Flannagan, Ronald S., Baron, Szilvia, Carraro-Lacroix, Luciene R., Wang, Dong, Vermeire, Wendy, Michiels, Christine, Munck, Sebastian, Baert, Veerle, Sugita, Shuzo, Wuytack, Frank, Hiesinger, Peter Robin, Grinstein, Sergio, Annaert, Wim“…We show here that N-glycosylation is not a prerequisite for proper targeting and function of this V-ATPase subunit both in vitro and in vivo in Drosophila melanogaster. We conclude that endo-lysosomal dysfunction in PSEN(−/−) cells is not a consequence of failed N-glycosylation of V0a1, or compromised lysosomal acidification. …”
Publicado 2012
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5695“…The web server implementation of the NetAligner algorithm presented here features complex, pathway and interactome to interactome alignments for seven model organisms, namely Homo sapiens, Mus musculus, Drosophila melanogaster, Caenorhabditis elegans, Arabidopsis thaliana, Saccharomyces cerevisiae and Escherichia coli. …”
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5696por Boitard, Simon, Schlötterer, Christian, Nolte, Viola, Pandey, Ram Vinay, Futschik, Andreas“…Applying our approach to Pool-Seq data from Drosophila melanogaster, we identify several selective sweep signatures on chromosome X that include some previously well-characterized sweeps like the wapl region.…”
Publicado 2012
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5697por Magnusson, Kalle, Lycett, Gareth J, Mendes, Antonio M, Lynd, Amy, Papathanos, Philippos-Aris, Crisanti, Andrea, Windbichler, Nikolai“…A phylogenomic comparison between Drosophila melanogaster, Aedes aegypti and Culex quinquefasciatus also indicates that the Anopheles X chromosome strongly disfavours the evolutionary conservation of male-biased expression and that novel male-biased genes are more likely to arise on autosomes. …”
Publicado 2012
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5698“…The daily cycle of melatonin biosynthesis in mammals is regulated by AANAT (arylalkylamine N-acetyltransferase; EC 2.3.1.87), making it an attractive target for therapeutic control of abnormal melatonin production in mood and sleep disorders. Drosophila melanogaster Dat (dopamine N-acetyltransferase) is an AANAT. …”
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5699por Dean, Rebecca, Perry, Jennifer C., Pizzari, Tommaso, Mank, Judith E., Wigby, Stuart“…Using genetic constructs to manipulate female fecundity and male mating success, we engineered a novel sexually antagonistic allele (SAA) in Drosophila melanogaster. The SAA is nearly twice as costly to females as it is beneficial to males, but the harmful effects to females are recessive and X-linked, and thus are rarely expressed when SAA occurs at low frequency. …”
Publicado 2012
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5700por Chen, Shanjun, Oliveira, Marcos T., Sanz, Alberto, Kemppainen, Esko, Fukuoh, Atsushi, Schlicht, Barbara, Kaguni, Laurie S., Jacobs, Howard T.“…Here we demonstrate cytoplasmic suppression of the mitochondrial disease-like phenotype of the Drosophila melanogaster nuclear mutant tko(25t), which includes developmental delay, seizure sensitivity, and defective male courtship. …”
Publicado 2012
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