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5921por Gamblin, Clémence L., Parent-Prévost, Frédérique, Jacquet, Kévin, Biehler, Cornélia, Jetté, Alexandra, Laprise, Patrick“…Drosophila melanogaster Yurt (Yrt) and its mammalian orthologue EPB41L5 limit apical membrane growth in polarized epithelia. …”
Publicado 2018
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5922por Battlay, Paul, Leblanc, Pontus B., Green, Llewellyn, Garud, Nandita R., Schmidt, Joshua M., Fournier-Level, Alexandre, Robin, Charles“…Patterns of nucleotide polymorphism within populations of Drosophila melanogaster suggest that insecticides have been the selective agents driving the strongest recent bouts of positive selection. …”
Publicado 2018
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5923“…Using a combination of experimental infections and behavioral choice assays, we tested if Drosophila melanogaster fruit flies avoid infectious environments at distinct developmental stages. …”
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5924“…We tested this hypothesis using thirteen strains of Drosophila melanogaster that each possessed a different mitochondrial haplotype in an otherwise standard nuclear genetic background. …”
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5925“…To distinguish between adaptation and relaxation hypotheses, we investigated the evidence of positive selection on protein-coding genes in relation to their expression over development, in fly Drosophila melanogaster, zebrafish Danio rerio, and mouse Mus musculus. …”
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5926“…This is in part due to the lack of comparative studies on species distantly related to Drosophila melanogaster. Therefore, we sequenced and assembled the genomes of two species of the virilis phylad (Drosophila novamexicana [15010-1031.00] and Drosophila americana [SF12]), which are diverging from D. melanogaster for more than 40 Myr. …”
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5927por Yevshin, Ivan, Sharipov, Ruslan, Kolmykov, Semyon, Kondrakhin, Yury, Kolpakov, Fedor“…The current version of the Gene Transcription Regulation Database (GTRD; http://gtrd.biouml.org) contains information about: (i) transcription factor binding sites (TFBSs) and transcription coactivators identified by ChIP-seq experiments for Homo sapiens, Mus musculus, Rattus norvegicus, Danio rerio, Caenorhabditis elegans, Drosophila melanogaster, Saccharomyces cerevisiae, Schizosaccharomyces pombe and Arabidopsis thaliana; (ii) regions of open chromatin and TFBSs (DNase footprints) identified by DNase-seq; (iii) unmappable regions where TFBSs cannot be identified due to repeats; (iv) potential TFBSs for both human and mouse using position weight matrices from the HOCOMOCO database. …”
Publicado 2019
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5928“…The insect mushroom body (MB) is a conserved brain structure that plays key roles in a diverse array of behaviors. The Drosophila melanogaster MB is the primary invertebrate model of neural circuits related to memory formation and storage, and its development, morphology, wiring, and function has been extensively studied. …”
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5929por Rao, Deepti S., Kronert, William A., Guo, Yiming, Hsu, Karen H., Sarsoza, Floyd, Bernstein, Sanford I.“…Using Drosophila melanogaster, we created the first animal models for myosin-based Freeman–Sheldon syndrome (FSS), a dominant form of distal arthrogryposis defined by congenital facial and distal skeletal muscle contractures. …”
Publicado 2019
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5930“…To explore the functional significance of this rapid divergence, we expressed Mtrm proteins from 12 different Drosophila species in the Drosophila melanogaster female germline. Distantly related Mtrm homologs are able to both physically interact with D. melanogaster Polo and rescue the meiotic defects seen in mtrm mutants. …”
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5931por Chen, Wen-Chi, Chou, Tzu-Yang, Chen, Huey-Yi, Yang, You-Rong, Man, Kee-Ming, Tsai, Ming-Yen, Chen, Yung-Hsiang“…Wild-type male Drosophila melanogaster CS flies were used in this study, with 0.25% ethylene glycol (EG) as a lithogenic agent. 2% potassium citrate (K-citrate) was the positive control agent for prevention (all agents added at the start of experiment) and treatment (drugs added after 2-week addition of lithogenic agent) studies compared with 15, 30, and 60 μg/ml of Danshen extract. …”
Publicado 2019
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5932por Merkling, Sarah H., Riahi, Human, Overheul, Gijs J., Schenck, Annette, van Rij, Ronald P.“…The fruit fly Drosophila melanogaster is a valuable model organism for the discovery and characterization of innate immune pathways, but host responses to virus infection remain incompletely understood. …”
Publicado 2019
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5933“…We also show that in Drosophila melanogaster as gene expression increases, a higher proportion of genes have ramp sequences. …”
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5934por Martins, Nelson, Lemoine, Aurélie, Santiago, Estelle, Paro, Simona, Imler, Jean-Luc, Meignin, Carine“…Here we describe transgenic Drosophila melanogaster lines encoding a Flock House Virus-derived replicon (FHV∆B2eGFP), expressing GFP as a reporter of viral replication. …”
Publicado 2018
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5935por Foriel, Sarah, Renkema, G. Herma, Lasarzewski, Yvonne, Berkhout, Job, Rodenburg, Richard J., Smeitink, Jan A. M., Beyrath, Julien, Schenck, Annette“…The fruit fly Drosophila melanogaster is a cost- and time-efficient model that can recapitulate a wide range of phenotypes observed in patients suffering from mitochondrial disorders. …”
Publicado 2019
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5936“…However, in the early Drosophila melanogaster embryo, the heterochromatin lacks these modifications, which appear only later, when rapid embryonic cell cycles slow down at the midblastula transition (MBT). …”
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5937por McCorkindale, Alexandra L., Wahle, Philipp, Werner, Sascha, Jungreis, Irwin, Menzel, Peter, Shukla, Chinmay J., Abreu, Rúben Lopes Pereira, Irizarry, Rafael A., Meyer, Irmtraud M., Kellis, Manolis, Zinzen, Robert P.“…Cell type specification during early nervous system development in Drosophila melanogaster requires precise regulation of gene expression in time and space. …”
Publicado 2019
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5938por Groot, Astrid T., van Wijk, Michiel, Villacis-Perez, Ernesto, Kuperus, Peter, Schöfl, Gerhard, van Veldhuizen, Dennis, Heckel, David G.“…This finding is in contrast to Drosophila melanogaster, where a single desaturase gene affects both female pheromone production and male behavioural response, but similar to other Lepidoptera where these traits are under independent genetic control. …”
Publicado 2019
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5939“…In this review, we present an overview of TBI pathology, discuss mammalian models for TBI and focus on current methods using Drosophila melanogaster as a model for TBI study. The relatively small brain size (∼100,000 neurons and glia), conserved neurotransmitter signaling mechanisms and sophisticated genetics of Drosophila allows for cell biological, molecular and genetic analyses that are impractical in mammalian models of TBI.…”
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5940Assessing the Architecture of Drosophila mojavensis Locomotor Evolution with Bulk Segregant Analysis“…Using three alternative statistical approaches, we found strong evidence for two relatively large-effect QTL that is localized in a region homologous to a region of densely packed behavior loci in Drosophila melanogaster, suggesting that clustering of behavior genes may display relatively deep evolutionary conservation. …”
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