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5981por Abrieux, Antoine, Xue, Yongbo, Cai, Yao, Lewald, Kyle M., Nguyen, Hoang Nhu, Zhang, Yong, Chiu, Joanna C.“…Here, we demonstrate that, in Drosophila melanogaster, EYES ABSENT (EYA) acts as a seasonal sensor by interpreting photoperiodic and temperature changes to trigger appropriate physiological responses. …”
Publicado 2020
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5982por Khallaf, Mohammed A., Auer, Thomas O., Grabe, Veit, Depetris-Chauvin, Ana, Ammagarahalli, Byrappa, Zhang, Dan-Dan, Lavista-Llanos, Sofía, Kaftan, Filip, Weißflog, Jerrit, Matzkin, Luciano M., Rollmann, Stephanie M., Löfstedt, Christer, Svatoš, Aleš, Dweck, Hany K. M., Sachse, Silke, Benton, Richard, Hansson, Bill S., Knaden, Markus“…These observations imply that subspecies-specific behaviors arise from differential interpretation of the same peripheral cue, reminiscent of sexually conserved detection but dimorphic interpretation of male pheromones in Drosophila melanogaster. Our results reveal that, during incipient speciation, pheromone production, detection, and interpretation do not necessarily evolve in a coordinated manner.…”
Publicado 2020
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5983por Walls, Stanley M., Chatfield, Dale A., Ocorr, Karen, Harris, Greg L., Bodmer, Rolf“…Sphingosine Δ4 desaturase (encoded by ifc in Drosophila melanogaster) enzymatically converts dihydroceramide into ceramide. …”
Publicado 2020
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5984“…We found substantial variation in resistance to the fly-specific pathogen Entomophthora muscae 'Berkeley' (Entomophthoromycota), in 20 lines from the Drosophila melanogaster Genetic Reference Panel (DGRP). Resistance to E. muscae is positively (r = 0.55) correlated with resistance to the broad host range ascomycete entomopathogen Metarhizium anisopliae (Ma549), indicative of generalist (non-specific) defenses. …”
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5985“…Research using the fruit fly Drosophila melanogaster has traditionally focused on understanding how mutations affecting gene regulation or function affect processes linked to animal development. …”
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5986por Maselko, Maciej, Feltman, Nathan, Upadhyay, Ambuj, Hayward, Amanda, Das, Siba, Myslicki, Nathan, Peterson, Aidan J., O’Connor, Michael B., Smanski, Michael J.“…Here, we demonstrate a general approach to create engineered genetic incompatibilities (EGIs) in the model insect Drosophila melanogaster. EGI couples a dominant lethal transgene with a recessive resistance allele. …”
Publicado 2020
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5987“…In this review, we collate transcriptional and epigenetic changes identified in adult Drosophila melanogaster dopaminergic neurons in response to either prolonged social deprivation or social enrichment, and compare them with changes identified in mammalian dopaminergic neurons during normal development, stress, injury, and neurodegeneration. …”
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5988por Manavalan, Balachandran, Hasan, Md. Mehedi, Basith, Shaherin, Gosu, Vijayakumar, Shin, Tae-Hwan, Lee, Gwang“…The tools 4mCCNN (Escherichia coli), DNA4mC-LIP (Arabidopsis thaliana), iDNA-MS (Fragaria vesca), DNA4mC-LIP and 4mCCNN (Drosophila melanogaster), and four tools for Caenorhabditis elegans achieved excellent overall performance compared with their counterparts. …”
Publicado 2020
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5989“…We discuss recent findings in Drosophila melanogaster showing that cell-autonomous environment and growth-sensing mechanisms, involving TOR and other growth-regulatory pathways, that converge on insulin and steroid relay centers are responsible for adjusting systemic growth, and development, in response to external and internal conditions. …”
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5990“…As a highly tractable and translatable genetic and behavioral model organism, Drosophila melanogaster has proven valuable to uncover important genes and mechanistic pathways that have obvious orthologs in humans and that help explain the complexities of addiction. …”
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5991por Runtuwene, Lucky R., Kawashima, Shuichi, Pijoh, Victor D., Tuda, Josef S. B., Hayashida, Kyoko, Yamagishi, Junya, Sugimoto, Chihiro, Nishiyama, Shoko, Sasaki, Michihito, Orba, Yasuko, Sawa, Hirofumi, Takasaki, Tomohiko, James, Anthony A., Kobayashi, Takashi, Eshita, Yuki“…In contrast, the RNAi-mediated suppression of l(2)efl gene products resulted in enhanced DENV-2 replication, but this enhancement occurred only if multiple l(2)efl genes were suppressed. l(2)efl homologs induce the phosphorylation of eukaryotic initiation factor 2α (eIF2α) in the fruit fly Drosophila melanogaster, and we confirmed this finding in the cell line. …”
Publicado 2020
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5992“…To further explore the biological role of the m-AAA proteases and the pathological consequences of their deficiency, we used a genetic approach in the fruit fly Drosophila melanogaster to inactivate the ATPase family gene 3-like 2 (AFG3L2) gene, which encodes a critical component of the m-AAA proteases. …”
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5993“…We used genome editing and established transgenic lines to visualize cells expressing the conserved transcription factor retinal homeobox, thereby marking homologous genetic neural lineages in both the fly Drosophila melanogaster and the beetle Tribolium castaneum. …”
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5994por Vlachakis, Dimitrios, Papageorgiou, Louis, Papadaki, Ariadne, Georga, Maria, Kossida, Sofia, Eliopoulos, Elias“…Much of what is known about Notch family proteins function comes from studies done in Caenorhabditis Elegans and Drosophila Melanogaster. Although, human Notch homologs had also been identified, the molecular mechanisms which modulate the Notch signaling pathway remained substantially unknown. …”
Publicado 2020
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5995por González de Cózar, Jose M, Carretero-Junquera, Maria, Ciesielski, Grzegorz L, Miettinen, Sini M, Varjosalo, Markku, Kaguni, Laurie S, Dufour, Eric, Jacobs, Howard T“…The enzyme comprises a C-terminal catalytic domain and an N-terminal hybrid-binding domain (HBD), separated by a linker of variable length, 115 amino acids in Drosophila melanogaster (Dm). Molecular modelling predicted this extended linker to fold into a structure similar to the conserved HBD. …”
Publicado 2020
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5996“…These sophisticated techniques are fundamentally genetic and have found their greatest application in genetic model organisms, such as the fruit fly Drosophila melanogaster. Drosophila combines genetic tractability with a compact, but cell-type rich, nervous system and has been the incubator for a variety of methods of neuronal targeting. …”
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5997por Mao, Decai, Jia, Yu, Peng, Ping, Shen, Da, Ren, Xingjie, Zhu, Ruibao, Qiu, Yuhao, Han, Yuting, Yu, Jinchao, Che, Qinyun, Li, Yutong, Lu, Xinyi, Liu, Lu-Ping, Wang, Zhao, Liu, Qingfei, Sun, Jin, Ni, Jian-Quan“…The flySAM/CRISPRa system has recently emerged as a powerful tool for gain-of-function studies in Drosophila melanogaster. This system includes Gal4/UAS-driven dCas9 activators and U6 promoter-controlled sgRNA. …”
Publicado 2020
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5998por Kessissoglou, Irini A., Langui, Dominique, Hasan, Amr, Maral, Maral, Dutta, Suchetana B., Hiesinger, Peter Robin, Hassan, Bassem A.“…We investigated the physiological function of APP in the adult brain using the fruit fly Drosophila melanogaster, which harbors a single APP homologue called APP Like (APPL). …”
Publicado 2020
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5999por Tripodi, Farida, Lombardi, Linda, Guzzetti, Lorenzo, Panzeri, Davide, Milanesi, Riccardo, Leri, Manuela, Bucciantini, Monica, Angeloni, Cristina, Beghelli, Daniela, Hrelia, Silvana, Onorato, Giada, Di Schiavi, Elia, Falletta, Ermelinda, Nonnis, Simona, Tedeschi, Gabriella, Labra, Massimo, Coccetti, Paola“…Here, we show that an aqueous extract of V. unguiculata beans delays senescence both in Saccharomyces cerevisiae and Drosophila melanogaster, in a Snf1/AMPK-dependent manner. …”
Publicado 2020
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6000“…The fruit fly Drosophila melanogaster is an established model organism in chronobiology, because genetic manipulation and breeding in the laboratory are easy. …”
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