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  1. 6021
    “…We demonstrate for the first time that adult Drosophila melanogaster glial cells undergo spontaneous functional recovery following crush injury. …”
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    A novel injury paradigm in the central nervous system of adult Drosophila: molecular, cellular and functional aspects
  2. 6022
    “…To gain insight into neurological functions of ZC3H14, we previously developed a Drosophila melanogaster model of ZC3H14 loss by deleting the fly ortholog, Nab2. …”
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    The RNA-binding protein Nab2 regulates the proteome of the developing Drosophila brain
  3. 6023
    “…Here, we establish a robust and easy-to-implement model of oral S. aureus infection using Drosophila melanogaster larvae that allowed us to follow the fate of S. aureus at the whole-organism level as well as the host immune responses. …”
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    Reactive Oxygen Species-Dependent Innate Immune Mechanisms Control Methicillin-Resistant Staphylococcus aureus Virulence in the Drosophila Larval Model
  4. 6024
    “…It was also shown that ILPs in Drosophila melanogaster can directly and indirectly regulate AKH. …”
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    Insulin-Like Peptides and Cross-Talk With Other Factors in the Regulation of Insect Metabolism
  5. 6025
    por Wainman, Alan
    Publicado 2021
    “…Studies have identified a conserved pathway of proteins required for centriole formation, and investigations using the embryo of the fruit fly Drosophila melanogaster have been crucial in elucidating their dynamics. …”
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    SAPs as a new model to probe the pathway of centriole and centrosome assembly
  6. 6026
    “…We describe previously unknown receptor gene–dependent mechanisms that ensure singular expression of receptors encoded by a tandem gene array [Ionotropic receptor 75c (Ir75c), Ir75b, and Ir75a, organized 5′ to 3′] in Drosophila melanogaster. Transcription from upstream genes in the cluster runs through the coding region of downstream loci and inhibits their expression in cis, most likely via transcriptional interference. …”
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    Olfactory receptor–dependent receptor repression in Drosophila
  7. 6027
    “…The vinegar fly Drosophila melanogaster is a pivotal model for invertebrate development, genetics, physiology, neuroscience, and disease. …”
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    DrosoPhyla: Resources for Drosophilid Phylogeny and Systematics
  8. 6028
    “…To address this, we analyzed testis single-cell RNA-sequencing (scRNA-seq) data from two Drosophila melanogaster strains. We found evidence that the X chromosome is equally transcriptionally active as autosomes in somatic and pre-meiotic cells, and less transcriptionally active than autosomes in meiotic and post-meiotic cells. …”
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    Single-cell RNA-sequencing reveals pre-meiotic X-chromosome dosage compensation in Drosophila testis
  9. 6029
    “…Here, we take advantage of the model organism Drosophila melanogaster to investigate the role of AMPs and lysozymes in regulation of gut microbiota structure and diversity. …”
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    Drosophila Antimicrobial Peptides and Lysozymes Regulate Gut Microbiota Composition and Abundance
  10. 6030
    por Huang, Zhiqi, Yang, Peng, Wang, Fan
    Publicado 2021
    “…In this study, a cellular repressor of E1A-stimulated gene (CREG)-like protein, which is highly conserved from Drosophila melanogaster to Homo sapiens, was further characterized in shrimp plasma. …”
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    Shrimp Plasma CREG Is a Hemocyte Activation Factor
  11. 6031
    “…Protein components of the invertebrate occluding junction—known as the septate junction (SJ)—are required for morphogenetic developmental events during embryogenesis in Drosophila melanogaster. In order to determine whether SJ proteins are similarly required for morphogenesis during other developmental stages, we investigated the localization and requirement of four representative SJ proteins during oogenesis: Contactin, Macroglobulin complement-related, Neurexin IV, and Coracle. …”
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    Septate junction proteins are required for egg elongation and border cell migration during oogenesis in Drosophila
  12. 6032
    “…Using male sterility genes identified in human, mouse, and fruit fly databases as a starting point, 103 Drosophila melanogaster genes were screened for their association with male sterility by tissue-specific RNAi knockdown and CRISPR/Cas9-mediated mutagenesis. …”
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    A cross-species approach for the identification of Drosophila male sterility genes
  13. 6033
    “…Yet, the internal structure of the organism remains similar, i.e., the system scales to organism size. Drosophila melanogaster has been a powerful model system for exploring scaling mechanisms. …”
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    Scaling of internal organs during Drosophila embryonic development
  14. 6034
    por Itoh, Kazuyoshi, Nishihara, Shoko
    Publicado 2021
    “…The functions of mucin-type O-glycans have been studied in the fruit fly, Drosophila melanogaster. The basic structures of mucin-type O-glycans, including Tn antigen (GalNAcα1-Ser/Thr) and T antigen (Galβ1–3GalNAcα1-Ser/Thr), as well as the glycosyltransferases that synthesize them, are conserved between Drosophila and mammals. …”
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    Mucin-Type O-Glycosylation in the Drosophila Nervous System
  15. 6035
    “…We currently are the only application to offer pre-trained models for six different eukaryotic organisms: Arabidopsis thaliana, Drosophila melanogaster, Gallus gallus, Homo sapiens, Oryza sativa and Saccharomyces cerevisiae. …”
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    TSSFinder—fast and accurate ab initio prediction of the core promoter in eukaryotic genomes
  16. 6036
    “…We exercised w(1118) Drosophila melanogaster, investigating the effects of sex and group size at different stages of their lifetime, and recorded their lifespan. …”
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    Exercising D. melanogaster Modulates the Mitochondrial Proteome and Physiology. The Effect on Lifespan Depends upon Age and Sex
  17. 6037
    “…In order to ascertain the heath properties in vitro and in vivo, toxicity activities were assayed in the Drosophila melanogaster and leukaemia cell models; genomic safety was also assessed in both models using genotoxicity, fragmentation and comet assay. …”
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    Role of Glucosinolates in the Nutraceutical Potential of Selected Cultivars of Brassica rapa
  18. 6038
    “…Here, we evaluate the CRISPR-Cas9 system in Drosophila melanogaster to assess its ability to induce stem cell-derived tumors in the intestine. …”
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    Conditional CRISPR-Cas Genome Editing in Drosophila to Generate Intestinal Tumors
  19. 6039
    “…Here, we report that in four different species – Caenorhabditis elegans, Caenorhabditis remanei, Drosophila melanogaster, and Danio rerio – octopamine and norepinephrine play an essential role in maintaining oocyte quiescence. …”
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    Maintenance of quiescent oocytes by noradrenergic signals
  20. 6040
    por Herrera, Paul, Cauchi, Ruben J.
    Publicado 2021
    “…Recent studies have just started to underscore the utility of the fruit fly Drosophila melanogaster as a model system to study virus-host interactions and pathogenicity. …”
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    ACE and ACE2: insights from Drosophila and implications for COVID-19
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