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6121“…Here, we find that NELF-depleted Drosophila melanogaster cells functionally recapitulate the NELF-independent pausing we previously observed in fission yeast (which lack NELF). …”
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6122por Kulkarni, Arpita, Ewen-Campen, Ben, Terao, Kanta, Matsumoto, Yukihisa, Li, Yaolong, Watanabe, Takayuki, Kao, Jonchee A., Parhad, Swapnil S., Ylla, Guillem, Mizunami, Makoto, Extavour, Cassandra G.“…One such gene, the novel insect-specific gene oskar, was first identified based on its role in establishing the Drosophila melanogaster germ line. We previously showed that this gene likely arose through an unusual domain transfer event involving bacterial endosymbionts and played a somatic role before evolving its well-known germ line function. …”
Publicado 2023
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6123por Álvarez-Ocaña, Raquel, Shahandeh, Michael P., Ray, Vijayaditya, Auer, Thomas O., Gompel, Nicolas, Benton, Richard“…We investigated the evolution and sensory basis of oviposition in Drosophila sechellia, a close relative of Drosophila melanogaster that exhibits extreme specialism for Morinda citrifolia noni fruit. …”
Publicado 2023
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6124por Kapun, Martin, Mitchell, Esra Durmaz, Kawecki, Tadeusz J, Schmidt, Paul, Flatt, Thomas“…Since the pioneering work of Dobzhansky in the 1930s and 1940s, many chromosomal inversions have been identified, but how they contribute to adaptation remains poorly understood. In Drosophila melanogaster, the widespread inversion polymorphism In(3R)Payne underpins latitudinal clines in fitness traits on multiple continents. …”
Publicado 2023
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6125por Sollazzo, Germano, Gouvi, Georgia, Nikolouli, Katerina, Aumann, Roswitha A, Djambazian, Haig, Whitehead, Mark A, Berube, Pierre, Chen, Shu-Huang, Tsiamis, George, Darby, Alistair C, Ragoussis, Jiannis, Schetelig, Marc F, Bourtzis, Kostas“…Furthermore, comparative transcriptomic analysis indicated the presence of 32 differentially expressed genes, and bioinformatic analysis revealed the presence of 33 orthologs with a described heat-sensitive phenotype of Drosophila melanogaster in this region. These data can be used in functional genetic studies to identify the tsl gene(s) and the causal mutation(s) responsible for the temperature-sensitive lethal phenotype in medfly, and potentially additional genes causing a similar phenotype.…”
Publicado 2023
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6126por Floc'hlay, Swann, Balaji, Ramya, Stanković, Dimitrije, Christiaens, Valerie M, Bravo González-Blas, Carmen, De Winter, Seppe, Hulselmans, Gert J, De Waegeneer, Maxime, Quan, Xiaojiang, Koldere, Duygu, Atkins, Mardelle, Halder, Georg, Uhlirova, Mirka, Classen, Anne-Kathrin, Aerts, Stein“…Here, we aim to characterize the regulatory states that emerge and cooperate in the wound response, using the Drosophila melanogaster wing disc as a model system, and compare these with cancer cell states induced by ras(V12)scrib(-/-) in the eye disc. …”
Publicado 2023
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6127por Zhuravlev, A.V., Zalomaeva, E.S., Egozova, E.S., Sokurova, V.V., Nikitina, E.A., Savvateeva-Popova, E.V.“…The signal pathway of actin remodeling, including LIM-kinase 1 (LIMK1) and its substrate cofilin, regulates multiple processes in neurons of vertebrates and invertebrates. Drosophila melanogaster is widely used as a model object for studying mechanisms of memory formation, storage, retrieval and forgetting. …”
Publicado 2023
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6128por Elya, Carolyn, Lavrentovich, Danylo, Lee, Emily, Pasadyn, Cassandra, Duval, Jasper, Basak, Maya, Saykina, Valerie, de Bivort, Benjamin“…Here, we leverage the Entomophthora muscae-Drosophila melanogaster “zombie fly” system to reveal the mechanistic underpinnings of summit disease, a manipulated behavior evoked by many fungal parasites. …”
Publicado 2023
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6129por Glastad, Karl M., Roessler, Julian, Gospocic, Janko, Bonasio, Roberto, Berger, Shelley L.“…Expression of hsalHSF2 in Drosophila melanogaster led to enhanced heat shock survival and extended life span in the absence of heat stress. …”
Publicado 2023
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6130por de Senes-Lopes, Tiago Felipe, da Luz, Jefferson Romáryo Duarte, Guterres, Zaira da Rosa, Barbosa, Eder A., Batista, Débora, Galdino, Ony Araújo, Ururahy, Marcela Abbott Galvão, Gomes dos Santos, Elizabeth Cristina, López, Jorge A., Araujo-Silva, Gabriel, Almeida, Maria das Graças“…Cytotoxicity, mutagenicity, and acute oral and repeated dose indicated no toxic effects on cell culture, Drosophila melanogaster, and Wistar rat exposure to different EBHE concentrations, respectively. …”
Publicado 2023
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6131por Ravenscroft, Thomas A., Jacobs, Ashleigh, Gu, Mingxue, Eberl, Daniel F., Bellen, Hugo J.“…The fruit fly Drosophila melanogaster has provided important insights into how sensory information is transduced by transient receptor potential (TRP) channels in the peripheral nervous system (PNS). …”
Publicado 2023
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6132por Dong, Haiyang, Yang, Xi, Wu, Lili, Zhang, Shixin, Zhang, Jian, Guo, Pengjuan, Du, Yiwen, Pan, Changkun, Fu, Ying, Li, Lei, Shi, Jilong, Zhu, Yanda, Ma, Hongru, Bian, Lina, Xu, Bingbing, Li, Guo, Shi, Feng, Huang, Jianhua, He, Haihuai, Jin, Yongfeng“…Drosophila melanogaster Down syndrome cell adhesion molecule 1 (Dscam1) encodes 19,008 diverse ectodomain isoforms via the alternative splicing of exon 4, 6, and 9 clusters. …”
Publicado 2023
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6133“…To explore potential mechanisms for host control of symbiont titer, we leveraged population genomic data from the model system Drosophila melanogaster. In this host, we found a number of SNPs associated with titer in candidate genes potentially relevant to host interactions with Wolbachia. …”
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6134“…We performed affinity purification-mass spectrometry (AP-MS) experiments with Drosophila melanogaster Strip as a bait protein and copurified additional Striatin-interacting phosphatase and kinase (STRIPAK) complex members from larval muscle tissue. …”
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6135por Dirnberger, Benedict, Korona, Dagmara, Popovic, Rebeka, Deery, Michael J., Barber, Helen, Russell, Steven, Lilley, Kathryn S.“…We showcase the method on the isolation of a low copy number plasma membrane receptor complex, the nicotinic acetylcholine receptor (nAChR), from adult Drosophila melanogaster heads. We demonstrate that these nanodiscs can be used to study native receptor–ligand interactions. …”
Publicado 2023
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6136por Fleck, Sophie A., Biswas, Puja, DeWitt, Emily D., Knuteson, Rebecca L., Eisman, Robert C., Nemkov, Travis, D’Alessandro, Angelo, Tennessen, Jason M., Rideout, Elizabeth J., Weaver, Lesley N.“…The ease of genetic manipulation in Drosophila melanogaster using the Gal4/UAS system has been beneficial in addressing key biological questions. …”
Publicado 2023
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6137por Guo, Lei, Qiao, Xiaomu, Haji, Diler, Zhou, Tianhao, Liu, Zhihan, Whiteman, Noah K., Huang, Jia“…We used in vivo genome editing in Drosophila melanogaster to evaluate the fitness effects of each putative resistance mutation and found that pleiotropy both facilitates and constrains the evolution of GABA receptor resistance. …”
Publicado 2023
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6138“…We performed genome- and transcriptome-wide analyses of TTS in Drosophila melanogaster and found that only 0.3% (123) of total unique transcripts (35,642) show the potential of forming 12-purine long triplex forming sites that contain at least one guanine. …”
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6139por Meissner, Justyna M., Akhmetova, Katarina, Szul, Tomasz, Viktorova, Ekaterina G., Sha, Bingdong, Bhatt, Jay M., Lee, Eunjoo J., Kahn, Richard A., Belov, George A., Chesnokov, Igor, Sztul, Elizabeth“…Herein, we identify the HDS3 domain as essential for GBF1 membrane association in mammalian cells and document the critical role of HDS3 during the development of Drosophila melanogaster. We show that upon binding to Golgi membranes, GBF1 undergoes conformational changes in regions bracketing the catalytic Sec7d. …”
Publicado 2023
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6140por Aalto, Anna L., Saadabadi, Atefeh, Lindholm, Fanny, Kietz, Christa, Himmelroos, Emmy, Marimuthu, Parthiban, Salo-Ahen, Outi M. H., Eklund, Patrik, Meinander, Annika“…METHODS: To study how stilbenoid compounds affect inflammatory signaling in vivo, we have utilized the fruit fly, Drosophila melanogaster, as a model system. To induce intestinal inflammation in the fly, we have fed flies with the intestinal irritant dextran sodium sulphate (DSS). …”
Publicado 2023
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