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6181Publicado 1989“…We have recently described the purification and characterization of an insulin-degrading enzyme (IDE) from Drosophila melanogaster that can cleave porcine insulin, is highly conserved through evolution and is developmentally regulated. …”
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6182Publicado 1989“…The Notch locus of Drosophila melanogaster is one of a small number of zygotically acting "neurogenic" genes involved in the correct segregation of neural from epidermal lineages during embryogenesis as well as in other postembryonic developmental events. …”
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6183Publicado 1995“…CP190, a protein of 1,096 amino acids from Drosophila melanogaster, oscillates in a cell cycle-specific manner between the nucleus during interphase, and the centrosome during mitosis. …”
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6184por Karp, Peter D., Keseler, Ingrid M., Shearer, Alexander, Latendresse, Mario, Krummenacker, Markus, Paley, Suzanne M., Paulsen, Ian, Collado-Vides, Julio, Gama-Castro, Socorro, Peralta-Gil, Martin, Santos-Zavaleta, Alberto, Peñaloza-Spínola, Mónica I., Bonavides-Martinez, César, Ingraham, John“…A comparison to genome annotations for other model organisms shows that the E. coli genome contains the most experimentally determined gene functions in both relative and absolute terms: 2941 (66%) for E. coli, 2319 (37%) for Saccharomyces cerevisiae, 1816 (5%) for Arabidopsis thaliana, 1456 (4%) for Mus musculus and 614 (4%) for Drosophila melanogaster. Database queries to EcoCyc survey the global properties of E. coli cellular networks and illuminate the extent of information gaps for E. coli, such as dead-end metabolites. …”
Publicado 2007
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6185“…Further evidence for this hypothesis was provided by experiments in which H-2K(b) produced in Drosophila melanogaster cells and immobilized on the surface of a tissue culture plate was able to stimulate hybridomas derived from these alloreactive T cells. …”
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6186“…Comparison with well studied arthropods such as Drosophila melanogaster and Anopheles gambiae suggests that female-biased patterns tend to be conserved, whereas male-biased genes are evolving faster in D. pulex. …”
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6187“…A quality validation of LTRharvest against a gold standard annotation for Saccharomyces cerevisae and Drosophila melanogaster shows a sensitivity of up to 90% and 97% and specificity of 100% and 72%, respectively. …”
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6188por Mayhew, George F, Bartholomay, Lyric C, Kou, Hang-Yen, Rocheleau, Thomas A, Fuchs, Jeremy F, Aliota, Matthew T, Tsao, I-Yu, Huang, Chiung-Yen, Liu, Tze-Tze, Hsiao, Kwang-Jen, Tsai, Shih-Feng, Yang, Ueng-Cheng, Perna, Nicole T, Cho, Wen-Long, Christensen, Bruce M, Chen, Cheng-Chen“…EST clusters were annotated and curated manually within ASAP (A Systematic Annotation Package for Community Analysis of Genomes) web portal according to BLAST results from comparisons to Genbank, and the Anopheles gambiae and Drosophila melanogaster genome projects. CONCLUSION: The resulting dataset is the first of its kind for this mosquito vector and provides a basis for future studies of mosquito vectors regarding the cascade of events that occurs in response to infection, and thereby providing insight into vector competence and innate immunity.…”
Publicado 2007
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6189Publicado 1992“…In this report we show that Drosophila melanogaster muscles contain the standard form of the thick filament protein paramyosin, as well as a novel paramyosin isoform, which we call miniparamyosin. …”
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6190Publicado 1992“…To gain insight into the structure of the kinesin stalk, we expressed it from a segment of the Drosophila melanogaster kinesin heavy chain gene and purified it from Escherichia coli. …”
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6191Publicado 1992“…We have used a combination of classical genetic, molecular genetic, histological, biochemical, and biophysical techniques to identify and characterize a null mutation of the myosin light chain-2 (MLC-2) locus of Drosophila melanogaster. Mlc2E38 is a null mutation of the MLC-2 gene resulting from a nonsense mutation at the tenth codon position. …”
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6192Publicado 1995“…We have cloned the oho31 gene of Drosophila melanogaster and determined its nucleotide sequence. …”
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6193por Tomancak, Pavel, Berman, Benjamin P, Beaton, Amy, Weiszmann, Richard, Kwan, Elaine, Hartenstein, Volker, Celniker, Susan E, Rubin, Gerald M“…RESULTS: We determined and documented embryonic expression patterns for 6,003 (44%) of the 13,659 protein-coding genes identified in the Drosophila melanogaster genome with over 70,000 images and controlled vocabulary annotations. …”
Publicado 2007
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6194“…While evidence challenging this hypothesis is accumulating with Caenorhabditis elegans, for Drosophila melanogaster it is still thought that insulin/IGF and the mechanisms of dietary restriction (DR) might as yet function through overlapping mechanisms. …”
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6195por Zou, Zhen, Evans, Jay D, Lu, Zhiqiang, Zhao, Picheng, Williams, Michael, Sumathipala, Niranji, Hetru, Charles, Hultmark, Dan, Jiang, Haobo“…In most cases, paralog counts are lower than those of Drosophila melanogaster or Anopheles gambiae but are substantially higher than those of Apis mellifera. …”
Publicado 2007
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6196por Juhász, Gábor, Hill, Jahda H., Yan, Ying, Sass, Miklós, Baehrecke, Eric H., Backer, Jonathan M., Neufeld, Thomas P.“…To determine potential in vivo functions of Vps34, we generated mutations in the single Drosophila melanogaster Vps34 orthologue, causing cell-autonomous disruption of autophagosome/autolysosome formation in larval fat body cells. …”
Publicado 2008
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6197“…In the well-studied insect Drosophila melanogaster, eight Sox genes have been identified and are involved in processes such as neurogenesis, dorsal-ventral patterning and segmentation. …”
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6198por Weaver, Daniel B, Anzola, Juan M, Evans, Jay D, Reid, Jeffrey G, Reese, Justin T, Childs, Kevin L, Zdobnov, Evgeny M, Samanta, Manoj P, Miller, Jonathan, Elsik, Christine G“…CONCLUSION: Computational approaches successfully identified miRNAs in the honey bee and indicated previously unrecognized miRNAs in the well-studied Drosophila melanogaster genome despite the 280 million year distance between these insects. …”
Publicado 2007
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6199“…RESULTS: Expression profiling using cDNA microarrays was conducted in Drosophila melanogaster adult female heads for 58 nearly isogenic lines from a North Carolina population and 50 from a California population. …”
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6200por Chen, Xiaohua, Hua, Haiqing, Balamurugan, Kuppusamy, Kong, Xiangming, Zhang, Limei, George, Graham N., Georgiev, Oleg, Schaffner, Walter, Giedroc, David P.“…Drosophila melanogaster MTF-1 (dMTF-1) is a copper-responsive transcriptional activator that mediates resistance to Cu, as well as Zn and Cd. …”
Publicado 2008
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