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6401por Tanimura, Ayako, Horiguchi, Taigo, Miyoshi, Keiko, Hagita, Hiroko, Noma, Takafumi“…In a previous study, Drosophila adenylate kinase isozyme 2 (Dak2) knockout was reported to cause developmental lethality at the larval stage in Drosophila melanogaster. In addition, two other studies reported that AK2 is a responsible gene for reticular dysgenesis (RD), a human disease that is characterized by severe combined immunodeficiency and deafness. …”
Publicado 2014
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6402“…We applied our method to two closely related Drosophila species, Drosophila melanogaster and D. simulans, in which we discovered 10 new HTs in addition to all the HTs previously detected in different studies, which underscores our method’s high sensitivity and specificity. …”
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6403“…These results are consistent with previous studies of the VRK/BAF signaling axis in Caenorhabditis elegans and Drosophila melanogaster and validate VRK1 as a key regulator of NE architecture and mitotic chromosome dynamics in mammalian cells.…”
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6404por Hild, M, Beckmann, B, Haas, SA, Koch, B, Solovyev, V, Busold, C, Fellenberg, K, Boutros, M, Vingron, M, Sauer, F, Hoheisel, JD, Paro, R“…In order to get a more complete gene content of the Drosophila melanogaster genome, we based our new D. melanogaster whole-transcriptome microarray, the Heidelberg FlyArray, on the combination of the Berkeley Drosophila Genome Project (BDGP) annotation and a novel ab initio gene prediction of lower stringency using the Fgenesh software. …”
Publicado 2004
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6405“…We describe a method for modeling the 3D organization of the interphase nucleus, and its application to analysis of chromosome-nuclear envelope (Chr-NE) attachments of polytene (giant) chromosomes in Drosophila melanogaster salivary glands. The model represents chromosomes as self-avoiding polymer chains confined within the nucleus; parameters of the model are taken directly from experiment, no fitting parameters are introduced. …”
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6406“…Existing models of invertebrate Class 2 B1 GPCR evolution are mainly centered on Caenorhabditis elegans and Drosophila melanogaster and a few other nematode and arthropod representatives. …”
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6407por Claudius, Ann-Katrin, Romani, Patrizia, Lamkemeyer, Tobias, Jindra, Marek, Uhlirova, Mirka“…The steroid-deficient ecdysoneless(1) (ecd(1)) strain of Drosophila melanogaster has long served to assess the impact of ecdysone on gene regulation, morphogenesis, or reproduction. …”
Publicado 2014
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6408por Kuzin, Boris A., Nikitina, Ekaterina A., Cherezov, Roman O., Vorontsova, Julia E., Slezinger, Mikhail S., Zatsepina, Olga G., Simonova, Olga B., Enikolopov, Grigori N., Savvateeva-Popova, Elena V.“…We now demonstrate synergistic interactions of spineless and CG5017 in pathways controlling oxidative stress response and long-term memory formation in Drosophila melanogaster. Oxidative stress was induced by low doses of X-ray irradiation of flies carrying hypomorphic mutation of spineless, mutation of CG5017, and their combination. …”
Publicado 2014
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6409por Hauling, Thomas, Krautz, Robert, Markus, Robert, Volkenhoff, Anne, Kucerova, Lucie, Theopold, Ulrich“…For this, animal models where genetic changes in specific cells and tissues can be performed in a controlled way have become increasingly important, including the fruitfly Drosophila melanogaster. Many tumor mutants in Drosophila affect the germline and, as a consequence, also the immune system itself, making it difficult to ascribe their phenotype to a specific tissue. …”
Publicado 2014
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6410por Obiero, George F. O., Mireji, Paul O., Nyanjom, Steven R. G., Christoffels, Alan, Robertson, Hugh M., Masiga, Daniel K.“…Glossina morsitans morsitans genome ORs and GRs were annotated using homologs of these genes in Drosophila melanogaster and an ab initio approach based on OR and GR specific motifs in G. m. morsitans gene models coupled to gene ontology (GO). …”
Publicado 2014
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6411por Siciliano, P., He, X.L., Woodcock, C., Pickett, J.A., Field, L.M., Birkett, M.A., Kalinova, B., Gomulski, L.M., Scolari, F., Gasperi, G., Malacrida, A.R., Zhou, J.J.“…This OBP has a high homology to Drosophila melanogaster OBPs OS-E and OS-F, which are associated with trichoid sensilla and co-expressed with the well-studied Drosophila pheromone binding protein LUSH. …”
Publicado 2014
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6412por Palsson, Arnar, Wesolowska, Natalia, Reynisdóttir, Sigrún, Ludwig, Michael Z., Kreitman, Martin“…Consistently, in this analysis of 13 regulatory elements in Drosophila melanogaster populations, single base and insertion/deletion polymorphism are rare in characterized regulatory elements. …”
Publicado 2014
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6413por Vásquez, Gissella M., Syed, Zainulabeuddin, Estes, Patricia A., Leal, Walter S., Gould, Fred“…In a previous study, the Drosophila melanogaster OR67d(GAL4);UAS system was used to functionally characterize the receptor for the major component of the sex pheromone in the tobacco budworm, Heliothis virescens Fabricius (Lepidoptera: Noctuidae), HvOR13. …”
Publicado 2013
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6414“…CONCLUSIONS: As a result of the work described here, the DAO provides a high-quality, queryable reference for the wild-type anatomy of Drosophila melanogaster and a set of terms to annotate data related to that anatomy. …”
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6415“…To examine these interactions in the context of longevity, we generated 18 “mito-nuclear” genotypes by placing mtDNA from strains of Drosophila melanogaster and D. simulans onto controlled nuclear backgrounds of D. melanogaster (Oregon-R, w (1118), SIR2 overexpression and control) and quantified the lifespan of each mitonuclear genotype on five different sugar:yeast diets spanning a range of caloric and dietary restriction (CR and DR). …”
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6416por Matsuo, Eriko, Yamada, Daichi, Ishikawa, Yuki, Asai, Tomonori, Ishimoto, Hiroshi, Kamikouchi, Azusa“…The fruit fly Drosophila melanogaster responds behaviorally to sound, gravity, and wind. …”
Publicado 2014
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6417por Tennessen, Jason M., Bertagnolli, Nicolas M., Evans, Janelle, Sieber, Matt H., Cox, James, Thummel, Carl S.“…The fruit fly Drosophila melanogaster also utilizes aerobic glycolysis to support the rapid growth that occurs during larval development. …”
Publicado 2014
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6418“…These are the homologs of ark and buffy Drosophila melanogaster genes, respectively, involved in activating and inhibiting PCD. …”
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6419por Wacker, Jessica, Rönicke, Raik, Westermann, Martin, Wulff, Melanie, Reymann, Klaus G, Dobson, Christopher M, Horn, Uwe, Crowther, Damian C, Luheshi, Leila M, Fändrich, Marcus“…RESULTS: We show that oligomer targeting with the KW1 antibody fragment, but not fibril targeting with the B10 antibody fragment, affects toxicity in Aβ-expressing Drosophila melanogaster. The effect of KW1 is observed to occur selectively with flies expressing Aβ(1–40) and not with those expressing Aβ(1–42) or the arctic variant of Aβ(1–42) This finding is consistent with the binding preference of KW1 for Aβ(1–40) oligomers that has been established in vitro. …”
Publicado 2014
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6420“…The target is a multicopy motif (designated ARM: A-supergroup repeat motif) discovered in the genome of wMel (the Wolbachia in Drosophila melanogaster). ARM is found in at least seven other Wolbachia A-supergroup strains infecting various Drosophila, the wasp Muscidifurax and the tsetse fly Glossina. …”
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