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6641por Mazin, Pavel V., Shagimardanova, Elena, Kozlova, Olga, Cherkasov, Alexander, Sutormin, Roman, Stepanova, Vita V., Stupnikov, Alexey, Logacheva, Maria, Penin, Aleksey, Sogame, Yoichiro, Cornette, Richard, Tokumoto, Shoko, Miyata, Yugo, Kikawada, Takahiro, Gelfand, Mikhail S., Gusev, Oleg“…Here, using published and newly generated datasets reflecting detailed transcriptome changes during anhydrobiosis, as well as a developmental series, we show that the TCTAGAA DNA motif, which closely resembles the binding motif of the Drosophila melanogaster heat shock transcription activator (Hsf), is significantly enriched in the promoter regions of desiccation-induced genes in P. vanderplanki, such as genes encoding late embryogenesis abundant (LEA) proteins, thioredoxins, or trehalose metabolism-related genes, but not in P. nubifer. …”
Publicado 2018
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6642por Siibak, Triinu, Clemente, Paula, Bratic, Ana, Bruhn, Helene, Kauppila, Timo E.S., Macao, Bertil, Rosenberger, Florian A., Lesko, Nicole, Wibom, Rolf, Naess, Karin, Nennesmo, Inger, Wedell, Anna, Peter, Bradley, Freyer, Christoph, Falkenberg, Maria, Wredenberg, Anna“…Using a combination of disease models of Drosophila melanogaster and in vitro biochemistry analysis, we compare the molecular consequences of the p.Y955H mutation to the well-documented p.Y955C mutation. …”
Publicado 2017
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6643“…How genes promote growth and coordinate adaptation to nutrient availability is still an open question. p53 is a transcription factor that commands the cellular response to different types of stresses. In adult Drosophila melanogaster, p53 regulates the metabolic adaptation to nutrient restriction that supports fly viability. …”
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6644por Langellotti, Simona, Romano, Giulia, Feiguin, Fabian, Baralle, Francisco Ernesto, Romano, Maurizio“…Given the high degree of functional similarity between the human and fly orthologs of TDP-43, Drosophila melanogaster is a simple and useful model to study the pathophysiological role of this protein in vivo. …”
Publicado 2018
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6645por Beck, Katherina, Hovhanyan, Anna, Menegazzi, Pamela, Helfrich-Förster, Charlotte, Raabe, Thomas“…This study focuses on the molecular function of Ribosomal S6 Kinase (RSK) in the Drosophila melanogaster circadian clock. Mutations in the human rsk2 gene cause Coffin–Lowry syndrome, which is associated with severe mental disabilities. …”
Publicado 2018
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6646por Lee, Hangnoh, Cho, Dong-Yeon, Wojtowicz, Damian, Harbison, Susan T., Russell, Steven, Oliver, Brian, Przytycka, Teresa M.“…We systematically examined the impact of Drosophila melanogaster deletions on gene expression profiles to ask whether increased expression variability owing to reduced gene dose might underlie this phenotypic heterogeneity. …”
Publicado 2017
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6647“…While previous studies have investigated the roles of Drosophila melanogaster Robo1’s five Immunoglobulin-like (Ig) domains, little is known about the importance of the three evolutionarily conserved Fibronectin (Fn) type-III repeats. …”
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6648por Lam, Alexander, Karekar, Priyanka, Shah, Kajol, Hariharan, Girija, Fleyshman, Michelle, Kaur, Harmehak, Singh, Harpreet, Gururaja Rao, Shubha“…We have carried out a paraquat (PQ) screen in Drosophila to identify ion channels regulating the ROS handling and survival in Drosophila melanogaster. Our screen has revealed that α1-subunits (D-type, T-type, and cacophony) of voltage-gated calcium channels (VGCCs) handle PQ-mediated ROS stress differentially in a gender-based manner. …”
Publicado 2018
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6649por Serrato-Salas, Javier, Hernández-Martínez, Salvador, Martínez-Barnetche, Jesús, Condé, Renaud, Alvarado-Delgado, Alejandro, Zumaya-Estrada, Federico, Lanz-Mendoza, Humberto“…We hypothesized that the Aedes aegypti orthologue of the Drosophila melanogaster hindsight gene (not previously annotated in Aedes aegypti transcriptome/genome) is part of the Delta-Notch pathway. …”
Publicado 2018
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6650“…By analyzing 85 genomes from five populations of Drosophila melanogaster, we discover that TEs commonly form tandem dimers. …”
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6651por Symonenko, Alexander V., Roshina, Natalia V., Krementsova, Anna V., Pasyukova, Elena G.“…Previously, we demonstrated that several genes that encode RNA polymerase II transcription factors and that are involved in the development of the nervous system affect life span in Drosophila melanogaster. Among other genes, escargot (esg) was demonstrated to be causally associated with an increase in the life span of male flies. …”
Publicado 2018
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6652por Konganti, Kranti, Guerrero, Felix D., Schilkey, Faye, Ngam, Peter, Jacobi, Jennifer L., Umale, Pooja E., Perez de Leon, Adalberto A., Threadgill, David W.“…Comparative genomics analysis with the Dipteran flies Musca domestica L., Drosophila melanogaster, and Lucilia cuprina, show that the horn fly is most closely related to M. domestica, sharing 8,748 orthologous clusters followed by D. melanogaster and L. cuprina, sharing 7,582 and 7,490 orthologous clusters respectively. …”
Publicado 2018
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6653por Kittelmann, Sebastian, Buffry, Alexandra D., Franke, Franziska A., Almudi, Isabel, Yoth, Marianne, Sabaris, Gonzalo, Couso, Juan Pablo, Nunes, Maria D. S., Frankel, Nicolás, Gómez-Skarmeta, José Luis, Pueyo-Marques, Jose, Arif, Saad, McGregor, Alistair P.“…The repeated evolutionary loss of larval trichomes among Drosophila species is caused by the loss of shavenbaby (svb) expression. svb is also required for development of leg trichomes, but the evolutionary gain of trichomes in the ‘naked valley’ on T2 femurs in Drosophila melanogaster is caused by reduced microRNA-92a (miR-92a) expression rather than changes in svb. …”
Publicado 2018
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6654SWI/SNF regulates half of its targets without the need of ATP-driven nucleosome remodeling by Brahmapor Jordán-Pla, Antonio, Yu, Simei, Waldholm, Johan, Källman, Thomas, Östlund Farrants, Ann-Kristin, Visa, Neus“…BACKGROUND: Brahma (BRM) is the only catalytic subunit of the SWI/SNF chromatin-remodeling complex of Drosophila melanogaster. The function of SWI/SNF in transcription has long been attributed to its ability to remodel nucleosomes, which requires the ATPase activity of BRM. …”
Publicado 2018
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6655por Kim, Taemook, Seo, Hogyu David, Hennighausen, Lothar, Lee, Daeyoup, Kang, Keunsoo“…Currently, it can process NGS data from popular model genomes such as, human (Homo sapiens), mouse (Mus musculus), dog (Canis lupus familiaris), plant (Arabidopsis thaliana), zebrafish (Danio rerio), fruit fly (Drosophila melanogaster), worm (Caenorhabditis elegans), and budding yeast (Saccharomyces cerevisiae) genomes. …”
Publicado 2018
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6656por Blount, Jessica R., Libohova, Kozeta, Marsh, Gregory B., Sutton, Joanna R., Todi, Sokol V.“…We generated Drosophila melanogaster lines that express Ub chains non-cleavable into mono-Ub by DUBs. …”
Publicado 2018
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6657“…If the mother experiences challenging environmental conditions, such as poor nutrition, previous studies in Drosophila melanogaster have demonstrated a plastic response wherein these mothers may produce larger eggs to buffer the offspring against the same difficult environment. …”
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6658por Lajbner, Zdeněk, Pnini, Reuven, Camus, M. Florencia, Miller, Jonathan, Dowling, Damian K.“…Here, we use laboratory-based experimental evolution in the fruit fly, Drosophila melanogaster, to test whether thermal selection can shift population frequencies of two mtDNA haplogroups whose natural frequencies exhibit clinal associations with latitude along the Australian east-coast. …”
Publicado 2018
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6659por Mortensen, Richard D., Moore, Regan P., Fogerson, Stephanie M., Chiou, Hellen Y., Obinero, Chimdindu V., Prabhu, Neel K., Wei, Angela H., Crawford, Janice M., Kiehart, Daniel P.“…Here, we used a set of large deletions (deficiencies), which collectively remove 98.5% of the genes on the right arm of Drosophila melanogaster’s 2(nd) chromosome to identify “dorsal closure deficiencies”. …”
Publicado 2018
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6660por Rodriguez, Tamy Portillo, Mast, Joshua D., Hartl, Tom, Lee, Tom, Sand, Peter, Perlstein, Ethan O.“…Here we conducted a natural history study and chemical-modifier screen on the Drosophila melanogaster NGLY1 homolog, Pngl. We generated a new fly model of NGLY1 Deficiency, engineered with a nonsense mutation in Pngl at codon 420 that results in a truncation of the C-terminal carbohydrate-binding PAW domain. …”
Publicado 2018
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