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  1. 6921
    “…For example, at low temperature and short day-length, Drosophila melanogaster enters a state called adult reproductive diapause. …”
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    Enhanced germline stem cell longevity in Drosophila diapause
  2. 6922
    “…Insect immune responses to multiple pathogen groups including viruses, bacteria, fungi, and entomopathogenic nematodes have traditionally been documented in model insects such as Drosophila melanogaster, or medically important insects such as Aedes aegypti. …”
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    Physiological and transcriptional immune responses of a non-model arthropod to infection with different entomopathogenic groups
  3. 6923
    “…Drosophila melanogaster tumor models are growing in popularity, driven by the high degree of genetic as well as functional conservation to humans. …”
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    Computed tomography with segmentation and quantification of individual organs in a D. melanogaster tumor model
  4. 6924
    “…This study compares whole-genome sequence variation of recently collected natural population samples of Drosophila melanogaster against a collection made approximately 35 years prior from the same locality—encompassing roughly 500 generations of evolution. …”
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    A Population Genomic Assessment of Three Decades of Evolution in a Natural Drosophila Population
  5. 6925
    “…OBJECTIVES: Drosophila melanogaster has become an excellent model organism to explore the genetic mechanisms underlying tumour progression. …”
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    Toll‐7 promotes tumour growth and invasion in Drosophila
  6. 6926
    “…The functional characterization of PaOctβ2R and the bioinformatics data uncovered that the monoaminergic receptor family in the hemimetabolic P. americana is similarly complex as in holometabolic model insects like Drosophila melanogaster and the honeybee, Apis mellifera. …”
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    PaOctβ2R: Identification and Functional Characterization of an Octopamine Receptor Activating Adenylyl Cyclase Activity in the American Cockroach Periplaneta americana
  7. 6927
    “…Although the molecular function of Gro has been investigated in holometabolous insects such as Aedes aegypti and Drosophila melanogaster, their role in the hemimetabolous insect, brown planthopper, and the relationship between NlGro/NlGro1-L and JH/ecdysone signaling pathway, remained unknown. …”
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    Role of Groucho and Groucho1-like in Regulating Metamorphosis and Ovary Development in Nilaparvata lugens (Stål)
  8. 6928
    “…Here, we characterized the R‐loop landscape in aging Drosophila melanogaster photoreceptor neurons and showed that bulk R‐loop levels increased with age. …”
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    Proper control of R‐loop homeostasis is required for maintenance of gene expression and neuronal function during aging
  9. 6929
    “…The piRNAs of Caenorhabditis elegans have been observed to bind targets with high mismatch tolerance and appear to lack specific transposon targets, unlike piRNAs in Drosophila melanogaster and other organisms. These observations support a model in which C. elegans piRNAs provide a broad, indiscriminate net of silencing, competing with siRNAs associated with the CSR-1 Argonaute that specifically protect self-genes from silencing. …”
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    piRNAs of Caenorhabditis elegans broadly silence nonself sequences through functionally random targeting
  10. 6930
    “…Here, we assess quantitative trait differentiation in gene expression levels and alternative splicing (intron usage) between three closely related pairs of natural populations of Drosophila melanogaster from contrasting thermal environments that reflect three separate instances of cold tolerance evolution. …”
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    Parallel and population-specific gene regulatory evolution in cold-adapted fly populations
  11. 6931
    “…Here we pursue this problem in the Drosophila melanogaster ON motion vision circuit(4,5), in which we record the membrane potentials of direction-selective T4 neurons and of their columnar input elements(6,7) in response to visual and pharmacological stimuli in vivo. …”
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    A biophysical account of multiplication by a single neuron
  12. 6932
    “…Here we present FlyWire, an online community for proofreading neural circuits in a Drosophila melanogaster brain, and explain how its computational and social structures are organized to scale up to whole-brain connectomics. …”
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    FlyWire: Online community for whole-brain connectomics
  13. 6933
    “…Here, we adapted native elongating transcript sequencing technology (NET-seq) to measure cotranscriptional splicing dynamics during the early developmental stages of Drosophila melanogaster embryos. Our results reveal the position of RNA polymerase II (Pol II) when both canonical and recursive splicing occur. …”
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    Transcription and splicing dynamics during early Drosophila development
  14. 6934
    “…The existence of three independent binary systems for conditional gene expression (Gal4/UAS; LexA/LexAop; QF/QUAS) has greatly expanded versatile genetic analyses in the Drosophila melanogaster; however, the experimental application of these tools is limited by the need to generate multiple collections of noninterchangeable transgenic fly strains for each inducible gene expression system. …”
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    A LexAop > UAS > QUAS trimeric plasmid to generate inducible and interconvertible Drosophila overexpression transgenes
  15. 6935
    “…In the arthropod model species Drosophila melanogaster, a dipteran fly, segmentation of the anterior–posterior body axis is under control of a hierarchic gene cascade. …”
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    Lack of evidence for conserved parasegmental grooves in arthropods
  16. 6936
    “…Here we show that the growth and body size response to moderate hypoxia (10% O(2)) in Drosophila melanogaster is systemically regulated via the steroid hormone ecdysone. …”
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    The steroid hormone ecdysone regulates growth rate in response to oxygen availability
  17. 6937
    “…Nevertheless, little is known about how enhancers evolve after gene duplication and how regulatory information is rewired between duplicated genes. The Drosophila melanogaster bric-a-brac (bab) complex, comprising the tandem paralogous genes bab1 and bab2, provides a paradigm to address these issues. …”
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    A shared ancient enhancer element differentially regulates the bric-a-brac tandem gene duplicates in the developing Drosophila leg
  18. 6938
    “…Aedes aegypti aeNKCC1 is an ortholog of Drosophila melanogaster Ncc69, a bumetanide-sensitive Na(+)- K(+)−2Cl(−) cotransporter (NKCC). …”
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    Sequence analysis and function of mosquito aeCCC2 and Drosophila Ncc83 orthologs
  19. 6939
    “…CCHamide-2 is a newly identified brain-gut neuropeptide that regulates feeding behavior in several insect species including Drosophila melanogaster. However, little is known about the mechanisms controlling the feeding-related behavior and metabolic functions modulated by CCHamide-2 in other insects. …”
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    CCHamide-2 Signaling Regulates Food Intake and Metabolism in Gryllus bimaculatus
  20. 6940
    “…TETs’ enzymatic function in demethylating 5-methyl cytosine in DNA is required for proper development and TETs are frequently mutated in cancer. Recently, Drosophila melanogaster Tet (dTet) was shown to be highly expressed in developing fly brains and discovered to play an important role in brain and muscle development as well as fly behavior. …”
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    Drosophila Tet Is Required for Maintaining Glial Homeostasis in Developing and Adult Fly Brains
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