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7041por Zhang, Yichi, Huang, Qiutang, Sheng, Chengwang, Liu, Genyan, Zhang, Kexin, Jia, Zhongqiang, Tang, Tao, Mao, Xin, Jones, Andrew K., Han, Zhaojun, Zhao, Chunqing“…Subsequently, G3’M(TMD3) was introduced into the Rdl gene of the fruit fly, Drosophila melanogaster, using the CRISPR/Cas9 system. Larvae of heterozygous lines bearing G3’M(TMD3) did not show significant resistance to avermectin, fipronil, broflanilide, and fluralaner. …”
Publicado 2023
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7042por Zhu, Xiaolong, Valbon, Wilson, Qiu, Mengdi, Hu, Chunhua T., Yang, Jingxiang, Erriah, Bryan, Jankowska, Milena, Dong, Ke, Ward, Michael D., Kahr, Bart“…FTEs, particularly per-fluorophenyl-trichloromethyl-ethanol (PFTE), exhibited rapid knockdown not only against Drosophila melanogaster but also against susceptible and resistant Aedes aegypti mosquitoes, major vectors of Dengue, Zika, yellow fever, and Chikungunya viruses. …”
Publicado 2023
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7043por Cavigliasso, Fanny, Savary, Loriane, Spangenberg, Jorge E, Gallart-Ayala, Hector, Ivanisevic, Julijana, Kawecki, Tadeusz J“…Here we study changes in metabolism associated with adaptation to nutrient shortage, evolved by replicate Drosophila melanogaster populations maintained on a nutrient-poor larval diet for over 240 generations. …”
Publicado 2023
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7044“…Spermatozoa in animal species are usually highly elongated cells with a long motile tail attached to a head that contains the haploid genome in a compact and often elongated nucleus. In Drosophila melanogaster, the nucleus is compacted two hundred-fold in volume during spermiogenesis and re-modeled into a needle that is thirty-fold longer than its diameter. …”
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7045“…In this study, we used Drosophila melanogaster to evaluate the effectiveness of molecular markers in estimating ID under suboptimal conditions. …”
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7046por da Silva Soares, Nuno Filipe, Quagliariello, Andrea, Yigitturk, Seren, Martino, Maria Elena“…To tackle this, we made use of the well-characterized Drosophila melanogaster/Lactiplantibacillus plantarum experimental model of nutritional symbiosis to generate a quantitative framework of gut microbes’ effect on the host. …”
Publicado 2023
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7047por Servettini, Ilenio, Talani, Giuseppe, Megaro, Alfredo, Setzu, Maria Dolores, Biggio, Francesca, Briffa, Michelle, Guglielmi, Luca, Savalli, Nicoletta, Binda, Francesca, Delicata, Francis, Bru–Mercier, Gilles, Vassallo, Neville, Maglione, Vittorio, Cauchi, Ruben J., Di Pardo, Alba, Collu, Maria, Imbrici, Paola, Catacuzzeno, Luigi, D’Adamo, Maria Cristina, Olcese, Riccardo, Pessia, Mauro“…In addition, NFA ameliorated the motor performance of a knock-in mouse model of EA1 and restored the neuromuscular transmission and climbing ability in Shaker (Kv1.1) mutant Drosophila melanogaster flies (Sh(5)). By virtue of its multiple actions, NFA has strong potential as an efficacious single-molecule-based therapeutic agent for EA1 and serves as a valuable model for drug discovery.…”
Publicado 2023
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7048“…Here we use the Drosophila melanogaster Y chromosome to investigate the relevance of sex chromosome heterochromatin in somatic organs in vivo. …”
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7049por Doyle, Dominique A, Burian, Florencia N, Aharoni, Benjamin, Klinder, Annabelle J, Menzel, Melissa M, Nifras, Gerard Carlo C, Shabazz-Henry, Ahad L, Palma, Bianca Ulrich, Hidalgo, Gisselle A, Sottolano, Christopher J, Ortega, Bianca M, Niepielko, Matthew G“…The copackaging of mRNAs into biomolecular condensates called germ granules is a conserved strategy to posttranscriptionally regulate germline mRNAs. In Drosophila melanogaster, mRNAs accumulate in germ granules by forming homotypic clusters, aggregates containing multiple transcripts from the same gene. …”
Publicado 2023
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7050por Bibi, Maria, Hussain, Adil, Ali, Farman, Ali, Asad, Said, Fazal, Tariq, Kaleem, Yun, Byung-Wook“…NCBI-CDD analysis showed the presence of a highly conserved 7tm_7 chemosensory receptor protein superfamily that includes gustatory and odorant receptors from insect species Anopheles gambiae and Drosophila melanogaster. Further, three significantly enriched ungapped motifs in the protein sequence of all 72 A. aegypti gustatory receptors were found. …”
Publicado 2023
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7051“…Leucine-rich repeats and immunoglobulin-like domains (LRIG) are transmembrane proteins shown to promote bone morphogenetic protein (BMP) signaling in Caenorhabditis elegans, Drosophila melanogaster, and mammals. BMPs comprise a subfamily of the transforming growth factor beta (TGFβ) superfamily, or TGFβ family, of ligands. …”
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7052por Deng, Ting, Su, Shichen, Yuan, Xun, He, Jinqiu, Huang, Ying, Ma, Jinbiao, Wang, Jia“…Small interference RNAs are the key components of RNA interference, a conserved RNA silencing or viral defense mechanism in many eukaryotes. In Drosophila melanogaster, Dicer-2 (DmDcr-2)-mediated RNAi pathway plays important roles in defending against viral infections and protecting genome integrity. …”
Publicado 2023
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7053“…Finally, we find that CBX3 and RAC1/EGFR genetically interact in the model organism Drosophila melanogaster, suggesting that the simultaneous overexpression as well as well the co-occurrence of high- or low-grade copy number alterations in these genes is not accidental and could reflect evolutionarily conserved functional relationships.…”
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7054por Kolonko-Adamska, M., Zawadzka-Kazimierczuk, A., Bartosińska-Marzec, P., Koźmiński, W., Popowicz, G., Krężel, A., Ożyhar, A., Greb-Markiewicz, B.“…Methoprene-tolerant (Met) and germ cell-expressed (Gce) proteins were shown to be juvenile hormone (JH) receptors of Drosophila melanogaster with partially redundant functions. …”
Publicado 2023
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7055por Rombaut, Antoine, Gallet, Romain, Qitout, Kenza, Samy, Mukherjy, Guilhot, Robin, Ghirardini, Pauline, Lazzaro, Brian P., Becher, Paul G., Xuéreb, Anne, Gibert, Patricia, Fellous, Simon“…We studied competition between two insect species, the invasive pest Drosophila suzukii and the model Drosophila melanogaster, whose larval ecological niches overlap in ripe, but not rotten, fruit. …”
Publicado 2023
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7056por Auradkar, Ankush, Guichard, Annabel, Kaduwal, Saluja, Sneider, Marketta, Bier, Ethan“…When targeted near transcriptional start sites, these short 14–15 nts tgRNAs efficiently repress expression of several target genes throughout somatic tissues in Drosophila melanogaster without generating any detectable target site mutations. tgRNAs also can activate target gene expression when complexed with a Cas9-VPR fusion protein or modulate enhancer activity, and can be incorporated into a gene-drive, wherein a traditional gRNA sustains drive while a tgRNA inhibits target gene expression.…”
Publicado 2023
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7057“…wingless expression is exquisitely regulated by different factors and enhancers in the imaginal wing discs of Drosophila melanogaster in four domains: the dorsal band, the dorso-ventral boundary, and the inner and outer ring domains. tonalli is a trithorax group gene that encodes a putative SUMO E3 ligase that binds to chromatin to regulate the expression of its targets, including the Hox genes. …”
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7058A plant cytorhabdovirus modulates locomotor activity of insect vectors to enhance virus transmissionpor Gao, Dong-Min, Qiao, Ji-Hui, Gao, Qiang, Zhang, Jiawen, Zang, Ying, Xie, Liang, Zhang, Yan, Wang, Ying, Fu, Jingyan, Zhang, Hua, Han, Chenggui, Wang, Xian-Bing“…Additionally, expression of BYSMV P6 in the CNS of transgenic Drosophila melanogaster disturbs circadian rhythm and induces high locomotor activity. …”
Publicado 2023
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7059por Venkei, Zsolt G., Gainetdinov, Ildar, Bagci, Ayca, Starostik, Margaret R., Choi, Charlotte P., Fingerhut, Jaclyn M., Chen, Peiwei, Balsara, Chiraag, Whitfield, Troy W., Bell, George W., Feng, Suhua, Jacobsen, Steven E., Aravin, Alexei A., Kim, John K., Zamore, Phillip D., Yamashita, Yukiko M.“…Here, using Suppressor of Stellate (Su(Ste)), a Y-linked Drosophila melanogaster piRNA locus as a model, we show that Su(Ste) piRNAs are made in the early male germline via 5′-to-3′ phased piRNA biogenesis initiated by maternally deposited 1360/Hoppel transposon piRNAs. …”
Publicado 2023
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7060por Chvilicek, Maggie M., Seguin, Alexandra, Lathen, Daniel R., Titos, Iris, Cummins-Beebe, Pearl N, Pabon, Miguel A., Miscevic, Masa, Nickel, Emily A., Merrill, Collin B, Rodan, Aylin R., Rothenfluh, Adrian“…Tolerance is historically not well-understood, and numerous researchers have turned to model organisms, particularly Drosophila melanogaster, to unravel its mechanisms. Flies have high translational relevance for human alcohol responses, and there is substantial overlap in disease-causing genes between flies and humans, including those associated with Alcohol Use Disorder. …”
Publicado 2023
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