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  1. 7321
    “…Furthermore, the NF1 gene mutations were referred with Canis lupus familiaris, Rattus norvegicus, Gallus gallus, Danio rerio, and Drosophila melanogaster NF1 sequencing for evolutionary conservativeness and then analyzed in Condel databases for pathogenicity prediction. …”
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    The investigation for potential modifier genes in patients with neurofibromatosis type 1 based on next-generation sequencing
  2. 7322
    “…Here we examined the trajectories of flying fruit flies (Drosophila melanogaster) and mosquitoes (Aedes aegypti) navigating in controlled plumes of attractive odorants. …”
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    History dependence in insect flight decisions during odor tracking
  3. 7323
    “…We herein modeled the study of UCHL1 in Drosophila melanogaster and investigated its functions in PD. …”
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    Drosophila Ubiquitin C-Terminal Hydrolase Knockdown Model of Parkinson’s Disease
  4. 7324
    “…Circadian plasticity of the visual system of Drosophila melanogaster depends on functioning of both the neuronal and glial oscillators. …”
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    Different Levels of Expression of the Clock Protein PER and the Glial Marker REPO in Ensheathing and Astrocyte-Like Glia of the Distal Medulla of Drosophila Optic Lobe
  5. 7325
    “…One of the mechanisms that facilitates social interaction is pheromone-based communication. In Drosophila melanogaster, the male-specific pheromone cis-vaccenyl acetate (cVA) elicits different responses in male and female flies, and functions to modulate behavior in a context and experience-dependent manner. …”
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    Odorant binding protein 69a connects social interaction to modulation of social responsiveness in Drosophila
  6. 7326
    “…In both vertebrates and invertebrates, including Drosophila melanogaster, dopamine is at the center of a network of neurotransmitters and neuromodulators acting in concert to encode rewards. …”
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    A Fly’s Eye View of Natural and Drug Reward
  7. 7327
    “…The fruit fly Drosophila melanogaster is a nice model organism for longevity investigations because of its biological features. …”
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    The Investigations of Nitric Oxide Influence on Lifespan of Fruit Fly D. melanogaster Transgenic Strain dNOS4
  8. 7328
    “…To explore the medical applications of the WAP peptide, a wap gene transgenic Drosophila melanogaster was constructed. In wap-expressing flies, high expression levels of wap gene (>100 times) were achieved, in contrast to those of control flies, by qRT-PCR analysis. …”
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    Expression of the Shrimp wap gene in Drosophila elicits defense responses and protease inhibitory activity
  9. 7329
    “…The K50 (lysine at amino acid position 50) homeodomain (HD) protein Orthodenticle (Otd) is critical for anterior patterning and brain and eye development in most metazoans. In Drosophila melanogaster, another K50HD protein, Bicoid (Bcd), has evolved to replace Otd's ancestral function in embryo patterning. …”
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    A feed-forward relay integrates the regulatory activities of Bicoid and Orthodenticle via sequential binding to suboptimal sites
  10. 7330
    por Dai, Hong-Jie, Singh, Onkar
    Publicado 2018
    “…The abbreviated term ‘SIN’ exemplifies such issue as it may stand for Sindbis virus or the sex-lethal interactor gene (Drosophila melanogaster). To overcome this ambiguity, entities should be identified by linking them to the respective entries in notable biological databases. …”
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    SPRENO: a BioC module for identifying organism terms in figure captions
  11. 7331
    “…The resulting phenotypes include muscle, cardiac, neuronal, lipodystrophic and metabolic pathologies, early aging phenotypes, and combined complex phenotypes. The Drosophila melanogaster genome codes for lamin B-type (lamin Dm), lamin A-type (lamin C), and for LEM-domain proteins, BAF, LINC-complex proteins and all typical nuclear proteins. …”
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    Laminopathies: what can humans learn from fruit flies
  12. 7332
    por Tran, Linh, Hamp, Tobias, Rost, Burkhard
    Publicado 2018
    “…RESULTS: We extracted reliable experimental data about which proteins interact (binary) for eight diverse model organisms from public databases, namely from Escherichia coli, Schizosaccharomyces pombe, Plasmodium falciparum, Drosophila melanogaster, Caenorhabditis elegans, Mus musculus, Rattus norvegicus, Arabidopsis thaliana, and for the previously used Homo sapiens and Saccharomyces cerevisiae. …”
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    ProfPPIdb: Pairs of physical protein-protein interactions predicted for entire proteomes
  13. 7333
    “…To verify this hypothesis, we analyzed SNP data derived from 216 natural strains of Drosophila melanogaster. Comparing SNPs located in functional and nonfunctional regions within experimentally validated cis-regulatory modules (CRMs) from D. melanogaster that are active in the blastoderm stage of development, we found that SNPs within functional regions tended to cause smaller DNA shape variations. …”
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    Analysis of Genetic Variation Indicates DNA Shape Involvement in Purifying Selection
  14. 7334
    “…Although the Drosophila melanogaster (fly) model is a popular platform for investigating diet-related phenomena, it can be challenging to measure the volume of agar-based food media flies consume. …”
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    Measurement of solid food intake in Drosophila via consumption-excretion of a dye tracer
  15. 7335
    “…OBJECTIVE: To develop an in vivo system to test the pathogenicity of human AIP mutations using the fruit fly Drosophila melanogaster. METHODS: We generated a null mutant of the Drosophila AIP orthologue, CG1847, a gene located on the Xchromosome, which displayed lethality at larval stage in hemizygous knockout male mutants (CG1847(exon1_3)). …”
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    In vivo bioassay to test the pathogenicity of missense human AIP variants
  16. 7336
    “…Moreover, the ttcA mutant demonstrated attenuated virulence in a Drosophila melanogaster host model. Site-directed mutagenesis analysis revealed that the conserved cysteine motifs involved in [Fe-S] cluster ligation were required for TtcA function. …”
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    Pseudomonas aeruginosa ttcA encoding tRNA-thiolating protein requires an iron-sulfur cluster to participate in hydrogen peroxide-mediated stress protection and pathogenicity
  17. 7337
    “…Here, we use the intimate relationship between mitochondria and oxygen availability to dissect the roles of nuclear DNA (nDNA) variation, mitochondrial DNA (mtDNA) variation, hypoxia, and their interactions on gene expression in Drosophila melanogaster. Mitochondria provide an important evolutionary and medical context for understanding G × G and G × E given their central role in integrating cellular signals. …”
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    Mitonuclear Interactions Mediate Transcriptional Responses to Hypoxia in Drosophila
  18. 7338
    “…To characterize cellular problems potentially triggered by Ca(V)2.1 gains of function, we engineered mutations encoding FHM1 amino-acid substitutions S218L (SL) and R192Q (RQ) into transgenes of Drosophila melanogaster Ca(V)2/cacophony. We expressed the transgenes pan-neuronally. …”
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    Drosophila Ca(V)2 channels harboring human migraine mutations cause synapse hyperexcitability that can be suppressed by inhibition of a Ca(2+) store release pathway
  19. 7339
    por Chu, Chong, Pei, Jingwen, Wu, Yufeng
    Publicado 2018
    “…RESULTS: We compare the performance of the new method with REPdenovo and RepARK on Human, Arabidopsis thaliana and Drosophila melanogaster short sequencing data. And the new method fully constructs more repeats in Repbase than the original REPdenovo and RepARK, especially for repeats of higher divergence rates and lower copy number. …”
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    An improved approach for reconstructing consensus repeats from short sequence reads
  20. 7340
    por Frolov, Roman V.
    Publicado 2018
    “…The role of Shaker-dependent IA in Drosophila melanogaster photoreceptors was previously investigated by comparing intracellular recordings from Shaker and wild-type photoreceptors. …”
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    On the role of transient depolarization-activated K(+) current in microvillar photoreceptors
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