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  1. 7421
    “…However, our understanding of the early genomic and functional evolution of tandemly arranged gene families remains incomplete as paralog sequence similarity hinders their accurate characterization. The Drosophila melanogaster-specific gene family Sdic is tandemly repeated and impacts sperm competition. …”
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    Understanding the Early Evolutionary Stages of a Tandem Drosophilamelanogaster-Specific Gene Family: A Structural and Functional Population Study
  2. 7422
    “…In order to investigate mechanisms underlying Alk oncogenic signaling, we conducted a genetic suppressor screen in Drosophila melanogaster. Our screen identified multiple loci important for Alk signaling, including members of Ras/Raf/ERK-, Pi3K-, and STAT-pathways as well as tailless (tll) and foxo whose orthologues NR2E1/TLX and FOXO3 are transcription factors implicated in human neuroblastoma. …”
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    Identification of the Wallenda JNKKK as an Alk suppressor reveals increased competitiveness of Alk-expressing cells
  3. 7423
    “…In the popular model organism Drosophila melanogaster, gene editing has so far relied exclusively on the prototypical CRISPR nuclease Cas9. …”
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    Multiplexed conditional genome editing with Cas12a in Drosophila
  4. 7424
    “…Moreover, population genomic analyses suggested that many genes of small effect enriched in developmental functional categories underlie variation in dormancy timing and overlap with gene sets associated with development rate in Drosophila melanogaster. Our transcriptional data also suggested that a recent evolutionary shift from a seasonally late to a seasonally early host plant drove more rapid development during diapause in the early fly population. …”
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    Genome-wide variation and transcriptional changes in diverse developmental processes underlie the rapid evolution of seasonal adaptation
  5. 7425
    “…Compared with holometabolous insects such as Drosophila melanogaster, the coding genes for sulfakinin, corazonin, arginine vasopressin-like peptide (AVLP), and trissin and the corresponding receptors were not found in A. craccivora. …”
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    Identification and Characterization of Neuropeptides and Their G Protein-Coupled Receptors (GPCRs) in the Cowpea Aphid Aphis craccivora
  6. 7426
    “…To investigate the genetic basis of tubulogenesis, we study the formation of Drosophila melanogaster eggshell structures, called dorsal appendages, which are produced by epithelial tubes. …”
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    Detecting New Allies: Modifier Screen Identifies a Genetic Interaction Between Imaginal disc growth factor 3 and combover, a Rho-kinase Substrate, During Dorsal Appendage Tube Formation in Drosophila
  7. 7427
    “…There are sex-specific and non sex-specific transcripts generated by alternative promoters as found in Drosophila melanogaster and other insects. RNAi knockdown of Bdtra transcripts showed that BdTRA controls the sex-specific splicing of Bddsx and Bdfru pre-mRNAs. …”
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    The transformer-2 and fruitless characterisation with developmental expression profiles of sex-determining genes in Bactrocera dorsalis and B. correcta
  8. 7428
    “…We used genetically tractable Drosophila melanogaster to explore the role of sirtuins in shaping signaling pathways in the context of a host-symbiont model. …”
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    Wolbachia and Sirtuin-4 interaction is associated with alterations in host glucose metabolism and bacterial titer
  9. 7429
    “…METHODS: Expression levels of some autophagy genes, Hook, Atg6, Atg8, and Cathepsin D, were measured using quantitative PCR in transgenic Drosophila melanogaster expressing either Aβ42 or Tau R406W. …”
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    Distinctive alteration in the expression of autophagy genes in Drosophila models of amyloidopathy and tauopathy
  10. 7430
    “…Many relevant aspects of mammal’s cardiac physiology have been mainly investigated in insect models such as Drosophila melanogaster and Periplaneta americana. Cardiac function has been poorly studied in the cockroach Gromphadorhina portentosa, which has some advantages for experimental purposes such as an easier culture, bigger organs and a robust physiology. …”
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    Three-dimensional analysis of the heart function and effect cholinergic agonists in the cockroach Gromphadorhina portentosa
  11. 7431
    “…ABSTRACT: The Hippo signaling pathway is an evolutionarily conserved pathway that was initially discovered in Drosophila melanogaster and was later found to have mammalian orthologues. …”
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    USP1 Regulates TAZ Protein Stability Through Ubiquitin Modifications in Breast Cancer
  12. 7432
    “…AVAILABILITY AND IMPLEMENTATION: To test the accuracy of T-lex3, we called 1630 individual TE insertions in Drosophila melanogaster, 1600 individual TE insertions in humans, and 3067 individual TE insertions in the rice genome. …”
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    T-lex3: an accurate tool to genotype and estimate population frequencies of transposable elements using the latest short-read whole genome sequencing data
  13. 7433
    “…We next use RNA interference in cultured Drosophila melanogaster cells to identify the gene required for m(2,2)G(26) formation on cytosolic tRNA. …”
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    Identification of the enzymes responsible for m(2,2)G and acp(3)U formation on cytosolic tRNA from insects and plants
  14. 7434
    “…Here, we used data on whole genome sequences, deep RNA sequencing, and high quality phenotypes for three quantitative traits in the ∼200 inbred lines of the Drosophila melanogaster Genetic Reference Panel (DGRP) to compare the prediction accuracies of gene expression and genotypes for three complex traits. …”
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    Leveraging Multiple Layers of Data To Predict Drosophila Complex Traits
  15. 7435
    “…To specifically investigate the role of PDCD2L in germ cells, we employed Drosophila melanogaster as a model system. Consistent with the mouse data, global knockdown of trus, the fly ortholog of PDCD2L, resulted in lethality in flies at the third instar larval stage. …”
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    Programmed Cell Death 2-Like (Pdcd2l) Is Required for Mouse Embryonic Development
  16. 7436
    “…A clear example is the series of binary cell-fate decisions that take place during asymmetric cell divisions that give rise to the sensory organs of Drosophila melanogaster. The regulated trafficking of Sanpodo, a transmembrane protein that potentiates receptor activity, plays a pivotal role in this process. …”
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    Phosphatidic acid increases Notch signalling by affecting Sanpodo trafficking during Drosophila sensory organ development
  17. 7437
    “…Upon binding its ligand ETH, ETHR initiates a precisely programed ecdysis behavior series and physiological events. In Drosophila melanogaster, the ethr gene produces two functionally distinct splicing isoforms, ethra and ethrb. …”
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    Two Splice Isoforms of Leptinotarsa Ecdysis Triggering Hormone Receptor Have Distinct Roles in Larva-Pupa Transition
  18. 7438
    “…Using this method, we generated novel recombination rate maps of three wild-derived strains of Drosophila melanogaster, which strongly correlate with previous measurements. …”
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    The Theory and Applications of Measuring Broad-Range and Chromosome-Wide Recombination Rate from Allele Frequency Decay around a Selected Locus
  19. 7439
    “…Here, we generate a Drosophila melanogaster model of Ras/Lkb1 mutant carcinoma. …”
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    The level of oncogenic Ras determines the malignant transformation of Lkb1 mutant tissue in vivo
  20. 7440
    “…In the fruit fly, Drosophila melanogaster, Sex Peptide (SP) is the best-characterized protein mediator of these effects. …”
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    Drosophila Sex Peptide controls the assembly of lipid microcarriers in seminal fluid
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