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  1. 7501
    por Ghosh, Samadri, Lehner, Christian F.
    Publicado 2022
    “…In many species, centromere identity is specified epigenetically by special nucleosomes containing a centromere-specific histone H3 variant, designated as CENP-A in humans and CID in Drosophila melanogaster. After partitioning of centromere-specific nucleosomes onto newly replicated sister centromeres, loading of additional CENP-A/CID into centromeric chromatin is required for centromere maintenance in proliferating cells. …”
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    Incorporation of CENP-A/CID into centromeres during early Drosophila embryogenesis does not require RNA polymerase II–mediated transcription
  2. 7502
    “…We thus investigated the responses of mitochondrial oxidative phosphorylation (OXPHOS) to temperature in three flying insects: the honeybee (Apis mellifera carnica), the fruit fly (Drosophila melanogaster) and the Colorado potato beetle (Leptinotarsa decemlineata). …”
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    Flexible Thermal Sensitivity of Mitochondrial Oxygen Consumption and Substrate Oxidation in Flying Insect Species
  3. 7503
    “…Finally, downregulation of the Ydj1 fly homologue, Droj2, improves stress resistance, mitochondrial morphology, and memory performance in a Drosophila melanogaster AD model. These data reveal an unexpected and detrimental role for specific HSP40s in promoting hallmarks of Abeta42 toxicity.…”
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    The HSP40 chaperone Ydj1 drives amyloid beta 42 toxicity
  4. 7504
    “…Based on 16S rRNA gene sequencing data, we compared the gut microbiota of medicinal insects [Periplaneta americana, Protaetia (Liocola) brevitarsis (Lewis) and Musca domestica], in their medicinal stages, and non-medicinal insects (Hermetia illucens L., Tenebrio molitor, and Drosophila melanogaster), and found that the intestinal microbial richness of medicinal insects was higher, and there were significant differences in the microbial community structure between the two groups. …”
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    16S rRNA Gene Sequencing Reveals Specific Gut Microbes Common to Medicinal Insects
  5. 7505
    “…Mammalian cell line authentication is reliant on short tandem repeat (STR) profiling; however, the relatively low STR mutation rate in Drosophila melanogaster at the individual level is likely to preclude the value of this technique. …”
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    A novel transposable element-based authentication protocol for Drosophila cell lines
  6. 7506
    “…This includes an atypical SNORD13-like RNA in Drosophila melanogaster which guides ac(4)C to 18S rRNA helix 45 despite lacking one of the two rRNA antisense elements. …”
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    Probing small ribosomal subunit RNA helix 45 acetylation across eukaryotic evolution
  7. 7507
    “…When the entire coding sequence of P. xylostella RyR was integrated into Drosophila melanogaster, the I4790M variant conferred ~4.4‐fold resistance to chlorantraniliprole and 22‐fold resistance to flubendiamide in the 3rd instar larvae, confirming that it imparts only a moderate level of resistance to diamide insecticides. …”
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    Diamide insecticide resistance in transgenic Drosophila and Sf9‐cells expressing a full‐length diamondback moth ryanodine receptor carrying an I4790M mutation
  8. 7508
    “…Both types of small RNAs use a Drosophila melanogaster pre-miRNA-1 based hairpin for their expression, either with perfect base-pairing in the stem region (shRNA-like) or containing two mismatches (miRNA-like). …”
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    Intron-derived small RNAs for silencing viral RNAs in mosquito cells
  9. 7509
    “…In most insects, the pre-blastoderm embryo is a syncytium: nuclei divide and move throughout the shared cytoplasm, ultimately reaching the cortex. In Drosophila melanogaster, some early nuclear movements result from pulsed cytoplasmic flows that are coupled to synchronous divisions. …”
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    Nuclear speed and cycle length co-vary with local density during syncytial blastoderm formation in a cricket
  10. 7510
    “…Here we predict thousands of gene functions in five model eukaryotes (Saccharomyces cerevisiae, Caenorhabditis elegans, Drosophila melanogaster, Mus musculus and Homo sapiens) using machine learning models exclusively trained with features derived from the location of genes in the genomes to which they belong. …”
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    Gene function prediction in five model eukaryotes exclusively based on gene relative location through machine learning
  11. 7511
    “…We further generated trafficking-optimized versions of Aion, which show enhanced membrane localization and allow precisely timed, long-lasting all-optical control of nociceptive responses in larvae of Drosophila melanogaster. Thus, Aion is an optogenetic silencing tool for inhibition of neuronal activity over many hours which can be switched between an active and inactive state with millisecond precision.…”
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    Aion is a bistable anion-conducting channelrhodopsin that provides temporally extended and reversible neuronal silencing
  12. 7512
    “…We used 11 sequences from Drosophila melanogaster and 10 from Homo sapiens, that are predicted de novo proteins from former studies, for heterologous expression. …”
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    Heterologous expression of naturally evolved putative de novo proteins with chaperones
  13. 7513
    “…Many recent studies of the fruit fly, Drosophila melanogaster, have described the mechanisms of post-mating changes within the female reproductive tract and digestive system. …”
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    The Effects of Male Seminal Fluid Proteins on Gut/Gonad Interactions in Drosophila
  14. 7514
    “…Additionally, we compared the dynamics of sex-biased gene expression during development in T. californicum to those of the holometabolous fly Drosophila melanogaster by reanalyzing publicly available RNA-seq data from third instar larval, pupal and adult stages. …”
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    Dynamics of sex-biased gene expression during development in the stick insect Timema californicum
  15. 7515
    “…The initial studies on insect PRRs were done using established dipteran model organisms such as Drosophila melanogaster, but there are differences in the numbers and functional role of PRRs in different insects. …”
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    Rhodnius prolixus uses the peptidoglycan recognition receptor rpPGRP-LC/LA to detect Gram-negative bacteria and activate the IMD pathway
  16. 7516
    “…When manP or manR is impaired, the mannose-induced inhibition of biofilm formation was reversed and intestinal colonization was significantly reduced in a Drosophila melanogaster infection model. Our results show that ManR recognizes mannose and fructose in the environment and facilitates V. cholerae survival in the host.…”
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    A mannose-sensing AraC-type transcriptional activator regulates cell–cell aggregation of Vibrio cholerae
  17. 7517
    “…Here, we investigate these hypotheses by examining differential gene expression in Drosophila melanogaster following several treatments that have widespread transcriptomic effects: bacterial infection, viral infection, and abiotic stress. …”
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    Induction and inhibition of Drosophila X chromosome gene expression are both impeded by the dosage compensation complex
  18. 7518
    “…We expressed fatty acyl-CoA desaturases from Drosophila melanogaster (Dmd9) or Lobesia botrana (Lbo_PPTQ) and fatty acyl-CoA reductase from Helicoverpa armigera (HarFAR) in combinations with 11 peroxisomal oxidases of different origins. …”
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    Biosynthesis of insect sex pheromone precursors via engineered β-oxidation in yeast
  19. 7519
    “…On the other hand, recent studies in Drosophila melanogaster demonstrated that chronic BL exposure across lifespan leads to accelerated aging manifested in reduced lifespan and brain neurodegeneration even in flies with genetically ablated eyes, suggesting that BL can damage cells and tissues not specialized for light perception. …”
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    Chronic blue light leads to accelerated aging in Drosophila by impairing energy metabolism and neurotransmitter levels
  20. 7520
    “…Methionine 1 (M1)‐linked ubiquitination plays a key role in the regulation of inflammatory nuclear factor‐κB (NF‐κB) signalling and is important for clearance of pathogen infection in Drosophila melanogaster. M1‐linked ubiquitin (M1‐Ub) chains are assembled by the linear ubiquitin E3 ligase (LUBEL) in flies. …”
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    M1‐linked ubiquitination facilitates NF‐κB activation and survival during sterile inflammation
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