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  1. 7521
    “…In addition, the toxicity of both compounds was verified in Drosophila melanogaster. Broth microdilution assays were performed to obtain the minimum inhibitory concentration (MIC) values of ellagic acid and gallic acid, whereas efflux pump inhibition was tested using a subinhibitory concentration of standard efflux pump inhibitors, gallic acid and ellagic acid (MIC/8), where the ability of these compounds to decrease the MIC of ethidium bromide (EtBr) and antibiotics was verified. …”
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    Evaluation of ellagic acid and gallic acid as efflux pump inhibitors in strains of Staphylococcus aureus
  2. 7522
    “…To investigate the relative enrichment of F(ST_MaxSNP) outliers from real data, we applied the two F(ST) statistics to a panel of Drosophila melanogaster populations. We found that F(ST_MaxSNP) had a genome-wide enrichment of outliers compared with demographic expectations, and though it yielded a lesser enrichment than window F(ST), it detected mostly unique outlier genes and functional categories. …”
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    Maximum SNP F(ST) Outperforms Full-Window Statistics for Detecting Soft Sweeps in Local Adaptation
  3. 7523
    “…G6PD overexpression in Drosophila Melanogaster and mice protects against metabolic stress, oxidative damage, and age-associated functional decline, and results in an extended median lifespan. …”
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    Glucose 6-P Dehydrogenase—An Antioxidant Enzyme with Regulatory Functions in Skeletal Muscle during Exercise
  4. 7524
    “…Thus, the present study aimed to evaluate the cellular effects of a copper(II) complex with 4-fluorophenoxyacetic acid hydrazide and 1,10-phenanthroline (1) on PCa cell lines, as well as the mutagenic/recombinogenic and anticarcinogenic potential of 1 in Drosophila melanogaster. PNT-2 (non-tumorigenic), LNCaP (hormone-responsive PCa) and PC-3 (androgen-independent PCa) cells were cultured, and cytotoxicity was assessed using the MTT assay. …”
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    Copper(II) Complex Containing 4-Fluorophenoxyacetic Acid Hydrazide and 1,10-Phenanthroline: A Prostate Cancer Cell-Selective and Low-Toxic Copper(II) Compound
  5. 7525
    “…Mutant screening in Drosophila melanogaster has identified teflon (tef) as being required specifically for alternative homolog conjunction (AHC) of autosomal bivalents. …”
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    Teflon promotes chromosomal recruitment of homolog conjunction proteins during Drosophila male meiosis
  6. 7526
    “…Mifepristone increases life span in female Drosophila melanogaster, and its molecular target(s) remain unclear. …”
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    A screen of small molecule and genetic modulators of life span in female Drosophila identifies etomoxir, RH5849 and unanticipated temperature effects
  7. 7527
    “…PSA also reduced prion levels in infected cerebellar organotypic slices and alleviated locomotor deficits in prion‐infected Drosophila melanogaster expressing ovine PrP(C). Hence, genome‐wide QUIPPER‐based perturbations can discover actionable cellular pathways involved in prion propagation. …”
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    An arrayed genome‐wide perturbation screen identifies the ribonucleoprotein Hnrnpk as rate‐limiting for prion propagation
  8. 7528
    “…The gene product, hTomm40, encoded in the APOE gene cluster, is a core component of TOM, the translocase that imports nascent proteins across the mitochondrial outer membrane. We used Drosophila melanogaster eyes as an in vivo model to investigate the relationship between elevated Tom40 (the Drosophila homologue of hTomm40) expression and neurodegeneration. …”
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    An increase in mitochondrial TOM activates apoptosis to drive retinal neurodegeneration
  9. 7529
    “…Replicated populations of the two parasitoids were subjected to 10 generations of laboratory selection on D. suzukii with Drosophila melanogaster serving as the co‐evolved host. We assessed developmental success of selected and control lines in generations 0, 3, and 10. …”
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    Limited gains in native parasitoid performance on an invasive host beyond three generations of selection
  10. 7530
    “…Here, we show that loss of TGS1 in Caenorhabditis elegans, Drosophila melanogaster and Danio rerio results in neurological phenotypes similar to those caused by survival motor neuron (SMN) deficiency. …”
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    TGS1 impacts snRNA 3′-end processing, ameliorates survival motor neuron-dependent neurological phenotypes in vivo and prevents neurodegeneration
  11. 7531
    “…When expressed together with genetically encoded Ca(2+) indicators in Drosophila melanogaster mushroom body output neurons, CapChRs mediate light-evoked Ca(2+) entry in brain explants.…”
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    Calcium-permeable channelrhodopsins for the photocontrol of calcium signalling
  12. 7532
    por Xie, Na, Gross, Aaron D.
    Publicado 2022
    “…Here, we investigated target‐site synergism using small molecule probes (agonist and antagonist) against the muscarinic system and their ability to enhance the toxicity of GABAergic insecticides in Drosophila melanogaster (Meigen). RESULTS: Oral delivery of pilocarpine (muscarinic agonist) enhanced the toxicity of dieldrin, fipronil, and lindane, resulting in synergist ratios (SRs) between 4–32‐fold (orally delivered) or between 2–67‐fold when insecticides were topically applied. …”
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    Muscarinic acetylcholine receptor activation synergizes the knockdown and toxicity of GABA‐gated chloride channel insecticides
  13. 7533
    “…To understand how the auditory system underlying acoustic communication could evolve, we conducted a systematic comparison of the early stages of the auditory neural circuit involved in song information processing between closely-related fruit-fly species. Male Drosophila melanogaster and D. simulans produce different sound signals during mating rituals, known as courtship songs. …”
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    Evolutionary conservation and diversification of auditory neural circuits that process courtship songs in Drosophila
  14. 7534
    por Armstrong, Noah S., Frank, C. Andrew
    Publicado 2023
    “…PHP is expressed at the Drosophila melanogaster larval neuromuscular junction (NMJ) synapse, as well as other NMJs. …”
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    The calcineurin regulator Sarah enables distinct forms of homeostatic plasticity at the Drosophila neuromuscular junction
  15. 7535
    “…To efficiently regulate histone biogenesis, the repetitive Drosophila melanogaster replication-dependent histone genes are arrayed and clustered at a single locus. …”
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    A bioinformatics screen reveals Hox and chromatin remodeling factors at the Drosophila histone locus
  16. 7536
    “…We show that the generation of secreted Pel contributes to the biomechanical properties of the biofilm and decreases the virulence of P. aeruginosa in Caenorhabditis elegans and Drosophila melanogaster. Our results reveal that glycoside hydrolases found in exopolysaccharide biosynthetic systems can help shape the soft matter attributes of a biofilm and propose that secreted matrix components be referred to as matrix associated to better reflect their influence.…”
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    Glycoside hydrolase processing of the Pel polysaccharide alters biofilm biomechanics and Pseudomonas aeruginosa virulence
  17. 7537
    “…Herein, we have dissected functional roles of a previously uncharacterized gene, CG3995, in cell-type specific dendritic development in Drosophila melanogaster. CG3995, which we have named bedwarfed (bdwf), encodes a zinc-finger BED-type protein which is required for proportional growth and branching of dendritic arbors, exhibits nucleocytoplasmic expression, and functions in both transcriptional and translational cellular pathways. …”
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    The Zinc-BED transcription factor Bedwarfed promotes proportional dendritic growth and branching through transcriptional and translational regulation in Drosophila
  18. 7538
    “…ABSTRACT: Research on Piwi proteins and piRNAs in insects has focused on three experimental models: oogenesis and spermatogenesis in Drosophila melanogaster, the antiviral response in Aedes mosquitoes and the molecular analysis of primary and secondary piRNA biogenesis in Bombyx mori-derived BmN4 cells. …”
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    What Are the Functional Roles of Piwi Proteins and piRNAs in Insects?
  19. 7539
    “…We show that the 52 C-terminal amino acid residues of Drosophila melanogaster CRY, lacking the canonical FAD-binding domain and tryptophan chain, are sufficient to facilitate magnetoreception. …”
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    Essential elements of radical pair magnetosensitivity in Drosophila
  20. 7540
    “…TA is expressed in both Caenorhabditis elegans and Drosophila melanogaster and plays important roles in the regulation of essential life functions in each organism. …”
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    Regulation and modulation of biogenic amine neurotransmission in Drosophila and Caenorhabditis elegans
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