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  1. 7661
    “…Phylogenetic analysis of CLIPs in P. xylostella, two other Lepidoptera species (Bombyx mori and Manduca sexta), and two more distantly related insects (Drosophila melanogaster and Apis mellifera) showed that seven of the 13 PxCLIPs were clustered with homologs of the Lepidoptera rather than other species. …”
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    Genome-wide identification and expression profiling of serine proteases and homologs in the diamondback moth, Plutella xylostella (L.)
  2. 7662
    “…To explore principles of TAD folding in Drosophila melanogaster, we performed Hi-C and poly(A)(+) RNA-seq in four cell lines of various origins (S2, Kc167, DmBG3-c2, and OSC). …”
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    Active chromatin and transcription play a key role in chromosome partitioning into topologically associating domains
  3. 7663
    “…However, a subsequent Drosophila melanogaster Orai crystal structure raises concerns about this model, as the side chains of W76 and Y80 are predicted to face the pore lumen and create a steric clash between bound CaM and other Orai1 pore helices. …”
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    Orai1 pore residues control CRAC channel inactivation independently of calmodulin
  4. 7664
    “…Wolbachia and Spiroplasma endosymbionts naturally inhabit various insects including Drosophila melanogaster fruit flies. Therefore, this symbiotic association is considered an excellent model to investigate whether endosymbiotic bacteria participate in host immune processes against certain pathogens. …”
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    Effects of co-occurring Wolbachia and Spiroplasma endosymbionts on the Drosophila immune response against insect pathogenic and non-pathogenic bacteria
  5. 7665
    “…Here we report that mutant alleles of wavy (wy), a classic locus of the fruit fly Drosophila melanogaster, map to IP(3) 3-kinase 2 (IP3K2), a member of the inositol polyphosphate kinase gene family. …”
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    The wavy Mutation Maps to the Inositol 1,4,5-Trisphosphate 3-Kinase 2 (IP3K2) Gene of Drosophila and Interacts with IP3R to Affect Wing Development
  6. 7666
    “…RESULTS: We identified neuropeptide precursor sequences within whole-body transcriptome data from these five hexapod groups and complemented this dataset with homologous sequences from three crustaceans (including Daphnia pulex), three myriapods, and the fruit fly Drosophila melanogaster. Our results indicate that the reported loss of several neuropeptide genes in a number of winged insects, particularly holometabolous insects, is a trend that has occurred within Pterygota. …”
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    Evolution of neuropeptides in non-pterygote hexapods
  7. 7667
    “…In this study, we systematically studied the associations between the CPEs and histone modifications by integrating the Drosophila Core Promoter Database and time-series ChIP-seq data for histone modifications (H3K4me3, H3K27ac, and H3K27me3) during development in Drosophila melanogaster via the modENCODE project. We classified 96 core promoters into four groups based on the presence or absence of the TATA box or DPE, calculated the histone modification ratio at the core promoter region, and transcribed region for each core promoter. …”
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    Classification of Promoters Based on the Combination of Core Promoter Elements Exhibits Different Histone Modification Patterns
  8. 7668
    “…Whereas nitrilase1 and Fhit are discrete proteins in mammals, they are merged in Drosophila melanogaster and Caenorhabditis elegans. According to the Rosetta-Stone hypothesis, proteins encoded as fusion proteins in one organism and as separate proteins in another organism may act in the same signalling pathway. …”
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    A novel role for the tumour suppressor Nitrilase1 modulating the Wnt/β-catenin signalling pathway
  9. 7669
    “…BACKGROUND: In contrast to the complexity found in mammals, only two Bcl-2 family genes have been found in Drosophila melanogaster including the pro-cell survival, human Bok-related orthologue, Buffy. …”
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    The Bcl-2 homologue Buffy rescues α-synuclein-induced Parkinson disease-like phenotypes in Drosophila
  10. 7670
    “…Loss-of-function mutations in ancestral orthologs of both genes in Drosophila melanogaster were associated with altered sensitivity to salt stress. …”
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    Trans-ethnic Fine Mapping Highlights Kidney-Function Genes Linked to Salt Sensitivity
  11. 7671
    “…When fungal spores were microinjected into Drosophila melanogaster, eight isolates proved to be highly pathogenic while the remaining strains showed moderate or no pathogenicity. …”
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    Isolation of fungi from dead arthropods and identification of a new mosquito natural pathogen
  12. 7672
    “…This species has a unique life history and several ecological features that differentiate it from other Diptera such as Drosophila melanogaster and blood-feeding mosquitoes. These features include a short, non-feeding adult life stage (1–2 days) and the use of a long-range sex pheromone produced and released by adult females. …”
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    A Sex Pheromone Receptor in the Hessian Fly Mayetiola destructor (Diptera, Cecidomyiidae)
  13. 7673
    “…Mammals have at least twenty proapoptotic and antiapoptotic Bcl-2 family members, in contrast, only two Bcl-2 family genes have been identified in Drosophila melanogaster, the proapoptotic mitochondrial localized Debcl and the antiapoptotic Buffy. …”
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    Bcl-2 homologue Debcl enhances α-synuclein-induced phenotypes in Drosophila
  14. 7674
    “…Citrate uptake modifies intracellular hepatic energy metabolism and is controlled by the conserved sodium-dicarboxylate cotransporter solute carrier family 13 member 5 (SLC13A5, mammalian homolog of INDY: mINDY). In Drosophila melanogaster and Caenorhabditis elegans INDY reduction decreased whole-body lipid accumulation. …”
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    Inhibition of citrate cotransporter Slc13a5/mINDY by RNAi improves hepatic insulin sensitivity and prevents diet-induced non-alcoholic fatty liver disease in mice
  15. 7675
    “…While only a few enhancer blocking IBPs have been identified in vertebrates, the common fruit fly Drosophila melanogaster harbors at least twelve different enhancer blocking IBPs. …”
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    Transcriptomic data from panarthropods shed new light on the evolution of insulator binding proteins in insects: Insect insulator proteins
  16. 7676
    “…The life cycle of many animals includes a larval stage(s) that precedes metamorphic transition to a reproductively active adult stage but, with the exception of Drosophila melanogaster and other insects, research on neuropeptide signaling has hitherto largely focused on adult animals. …”
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    Localization of Neuropeptide Gene Expression in Larvae of an Echinoderm, the Starfish Asterias rubens
  17. 7677
    “…It is now established that the basic structural and functional elements are highly conserved from sponges to the crown taxa within the Protostomia (Drosophila melanogaster and Caenorhabditis elegans) and Deuterostomia (human); therefore, it is obvious that the molecular etiology of diseases within the metazoan animals have a common basis. …”
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    Traditional and Modern Biomedical Prospecting: Part II—the Benefits: Approaches for a Sustainable Exploitation of Biodiversity (Secondary Metabolites and Biomaterials from Sponges)
  18. 7678
    por Lafont, R., Dinan, L.
    Publicado 2003
    “…Abbreviation: / 20E: 20-hydroxyecdysone 2d20E: 2-deoxy-20-hydroxyecdysone 2dE: 2-deoxyecdysone BAH: bisacylhydrazine BmEcR: Bombyx mori EcR CfEcR: Choristoneura fumiferana EcR CfUSP: Choristoneura fumiferana USP CHO: Chinese hamster ovary CMV: cytomegalovirus DBD: DNA-binding domain DmEcR: Drosophila melanogaster EcR AbbE: ecdysone EcR: ecdysteroid receptor EcRE: ecdysteroid response element EHT: effective half-time ERE: oestrogen response element GR: glucocorticoid receptor GRE: glucocorticoid response element HEK: human embryonic kidney HvEcR: Heliothis virescens EcR LBD: ligand binding domain murA: muristerone A PKA: protein kinase A polB: polypodine B ponA: ponasterone A PPAR: peroxisome proliferator-activated receptor RAR: retinoic acid receptor RXR: retinoid X receptor TR: thyroid receptor USP: ultraspiracle VDR: vitamin D receptor VEGF: vascular endothelial growth factor…”
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    Practical uses for ecdysteroids in mammals including humans: an update
  19. 7679
    “…The ΔfinR mutant showed an increased paraquat sensitivity phenotype and attenuated virulence in the Drosophila melanogaster host model. These phenotypes could be complemented by high expression of fprA, indicating that the observed phenotypes of the ΔfinR mutant arose from the inability to up-regulate fprA expression. …”
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    The FinR-regulated essential gene fprA, encoding ferredoxin NADP(+) reductase: Roles in superoxide-mediated stress protection and virulence of Pseudomonas aeruginosa
  20. 7680
    “…Applying a correction factor deduced from a parallel analysis performed with Drosophila melanogaster ORESTES, we estimate that approximately half of these no-match ESTs contigs (22%) should represent Apis-specific genes. …”
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    The use of Open Reading frame ESTs (ORESTES) for analysis of the honey bee transcriptome
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