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7701por Yan, Wen, Zheng, Chunge, He, Jiayang, Zhang, Wenjie, Huang, Xin-An, Li, Xiong, Wang, Yutao, Wang, Xinhua“…The docking score of Drosophila melanogaster MAN2A1 (3BVT) was 11.3029, whereas that of POLR2A was 9.0133. …”
Publicado 2018
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7702por Calcino, Andrew D., Fernandez-Valverde, Selene L., Taft, Ryan J., Degnan, Bernard M.“…This approach was validated on 11 small RNA libraries in Drosophila melanogaster, demonstrating the successful annotation of RNAi-associated loci with properties consistent with previous reports. …”
Publicado 2018
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7703“…There is no or very limited overlap between An. stephensi pEZGs and Drosophila melanogaster or Aedes aegypti pEZGs. Interestingly, the upstream region of An. stephensi pEZGs lack significant enrichment of a previously reported TAGteam/VBRGGTA motif found in the regulatory region of pEZGs in D. melanogaster and Ae. aegypti. …”
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7704por Huang, Yu-Chi, Wang, Cheng-Te, Su, Ta-Shun, Kao, Kuo-Wei, Lin, Yen-Jen, Chuang, Chao-Chun, Chiang, Ann-Shyn, Lo, Chung-Chuan“…While considerable effort has been dedicated into simulating primate or rodent brains, the fruit fly (Drosophila melanogaster) is becoming a promising model animal in computational neuroscience for its small brain size, complex cognitive behavior, and abundancy of data available from genes to circuits. …”
Publicado 2019
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7705por Rass, Mathias, Oestreich, Svenja, Guetter, Severin, Fischer, Susanne, Schneuwly, Stephan“…However, to be able to characterize the endogenous Fuss function in Drosophila melanogaster, we have generated a number of state of the art tools including anti-Fuss antibodies, specific fuss-Gal4 lines and fuss mutant fly lines via the CRISPR/Cas9 system. …”
Publicado 2019
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7706por Adamski, Zbigniew, Bufo, Sabino A., Chowański, Szymon, Falabella, Patrizia, Lubawy, Jan, Marciniak, Paweł, Pacholska-Bogalska, Joanna, Salvia, Rosanna, Scrano, Laura, Słocińska, Małgorzata, Spochacz, Marta, Szymczak, Monika, Urbański, Arkadiusz, Walkowiak-Nowicka, Karolina, Rosiński, Grzegorz“…Among insects, Drosophila melanogaster, Galleria mellonella, Apis mellifera, Bombyx mori, Periplaneta americana, and Locusta migratoria are often used. …”
Publicado 2019
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7707“…Using different Drosophila melanogaster host genotypes and two bacterial pathogens, Lactococcus lactis and Pseudomonas entomophila, we tested whether previous exposure results in resistance or tolerance and whether it modifies immune gene expression during an acute‐phase infection (one day post‐challenge). …”
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7708por Bräcker, Lasse B., Schmid, Christian A., Bolini, Verena A., Holz, Claudia A., Prud’homme, Benjamin, Sirota, Anton, Gompel, Nicolas“…Using high-speed imaging, we quantified in depth the oviposition behavior of single females of Drosophila suzukii, Drosophila biarmipes and Drosophila melanogaster in a novel behavioral assay. By computing transitions between microbehaviors, we identified a common ethogram structure underlying oviposition of all three species. …”
Publicado 2019
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7709“…BACKGROUND: The gap gene system controls the early cascade of the segmentation pathway in Drosophila melanogaster as well as other insects. Owing to its tractability and key role in embryo patterning, this system has been the focus for both computational modelers and experimentalists. …”
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7710por Duc, Céline, Yoth, Marianne, Jensen, Silke, Mouniée, Nolwenn, Bergman, Casey M., Vaury, Chantal, Brasset, Emilie“…RESULTS: To address this question, we analyze Drosophila melanogaster lines harboring a deletion within flamenco, a major piRNA cluster specifically expressed in somatic follicular cells. …”
Publicado 2019
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7711por Mazaud, David, Kottler, Benjamin, Gonçalves-Pimentel, Catarina, Proelss, Sandra, Tüchler, Nadine, Deneubourg, Celine, Yuasa, Yoshihiro, Diebold, Celine, Jungbluth, Heinz, Lai, Eric C., Hirth, Frank, Giangrande, Angela, Fanto, Manolis“…The fruitfly Drosophila melanogaster has been extensively used as a genetic model for the maintenance of nervous system's functions. …”
Publicado 2019
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7712por Fouchécourt, Sophie, Picolo, Floriane, Elis, Sébastien, Lécureuil, Charlotte, Thélie, Aurore, Govoroun, Marina, Brégeon, Mégane, Papillier, Pascal, Lareyre, Jean-Jacques, Monget, Philippe“…RESULTS: We retrieved 379 Drosophila melanogaster genes that are functionally involved in male reproduction according to their mutant phenotypes and listed their vertebrate orthologs. 83% of the fly genes have at least one vertebrate ortholog for a total of 625 mouse orthologs. …”
Publicado 2019
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7713por Chen, Xia, Luan, Xiaojin, Zheng, Qianwen, Qiao, Chen, Chen, Wanyin, Wang, Min, Yan, Yidan, Xie, Bing, Shen, Cong, He, Zeyu, Zhang, Jun, Liu, Mingxi, Hu, Xing, Li, Hong, Zheng, Bo, Fang, Jie, Yu, Jun“…In the present study, using genetic manipulation of a Drosophila melanogaster testis model, we demonstrated that Prp3 is essential for male fertility in Drosophila. …”
Publicado 2019
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7714“…These data show that peripheral circadian rhythms and clocks should also be considered in “non-conventional” molecular model systems, i.e., outside Drosophila melanogaster, Danio rerio, and Mus musculus, and build a basic foundation for future investigations of interactions of clocks with different period lengths in marine organisms.…”
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7715por Luna-Peláez, Noelia, March-Díaz, Rosana, Ceballos-Chávez, María, Guerrero-Martínez, Jose A., Grazioli, Paolo, García-Gutiérrez, Pablo, Vaccari, Thomas, Massa, Valentina, Reyes, Jose C., García-Domínguez, Mario“…Functional analysis in vivo, using mutants of Drosophila melanogaster, confirmed the genetic interaction between Nipped-B and fs(1)h, the orthologs of human NIPBL and BRD4, respectively. …”
Publicado 2019
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7716por Ramos, Ana Patricia, Gustafsson, Ola, Labert, Nicolas, Salecker, Iris, Nilsson, Dan-Eric, Averof, Michalis“…Yet our ability to genetically manipulate the visual system to investigate its function is largely limited to a single species, the fruit fly Drosophila melanogaster. Here, we describe the visual system of Parhyale hawaiensis, an amphipod crustacean for which we have established tailored genetic tools. …”
Publicado 2019
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7717por Fang, Evandro F., Hou, Yujun, Lautrup, Sofie, Jensen, Martin Borch, Yang, Beimeng, SenGupta, Tanima, Caponio, Domenica, Khezri, Rojyar, Demarest, Tyler G., Aman, Yahyah, Figueroa, David, Morevati, Marya, Lee, Ho-Joon, Kato, Hisaya, Kassahun, Henok, Lee, Jong-Hyuk, Filippelli, Deborah, Okur, Mustafa Nazir, Mangerich, Aswin, Croteau, Deborah L., Maezawa, Yoshiro, Lyssiotis, Costas A., Tao, Jun, Yokote, Koutaro, Rusten, Tor Erik, Mattson, Mark P., Jasper, Heinrich, Nilsen, Hilde, Bohr, Vilhelm A.“…At the organismal level, NAD(+) repletion remarkably extends lifespan and delays accelerated aging, including stem cell dysfunction, in Caenorhabditis elegans and Drosophila melanogaster models of WS. Our findings suggest that accelerated aging in WS is mediated by impaired mitochondrial function and mitophagy, and that bolstering cellular NAD(+) levels counteracts WS phenotypes.…”
Publicado 2019
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7718por Singh, Samarjeet, Giesecke, Astrid, Damulewicz, Milena, Fexova, Silvie, Mazzotta, Gabriella M., Stanewsky, Ralf, Dolezel, David“…Drosophila melanogaster has served as an excellent genetic model to decipher the molecular basis of the circadian clock. …”
Publicado 2019
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7719por Pazos Obregón, Flavio, Palazzo, Martín, Soto, Pablo, Guerberoff, Gustavo, Yankilevich, Patricio, Cantera, Rafael“…Previously, we had trained an ensemble machine learning model to assign a probability of having synaptic function to every protein-coding gene in Drosophila melanogaster. This approach resulted in the publication of a catalogue of 893 genes which we postulated to be very enriched in genes with a still undocumented synaptic function. …”
Publicado 2019
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7720“…Models of the Hippo pathway have evolved from a series of genetic interactions defined in the fruit fly Drosophila melanogaster into a complex series of biochemical mechanisms in which transmembrane and cytoskeletal proteins modulate cytoplasmic phosphatase and kinase activities that converge on the serine/threonine kinase Warts (Wts) to regulate nuclear entry of the co-activator protein Yorkie (Yki; vertebrate Yap1). …”
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