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  1. 7801
    “…The loss of Wnt subfamilies appears to be common in insects, but little is known about the Wnt repertoire in other arthropods, and moreover the expression and function of these genes have only been investigated in a few protostomes outside the relatively Wnt-poor model species Drosophila melanogaster and Caenorhabditis elegans. To investigate the evolution of this important gene family more broadly in protostomes, we surveyed the Wnt gene diversity in the crustacean Daphnia pulex, the chelicerates Ixodes scapularis and Achaearanea tepidariorum, the myriapod Glomeris marginata and the annelid Platynereis dumerilii. …”
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    Conservation, loss, and redeployment of Wnt ligands in protostomes: implications for understanding the evolution of segment formation
  2. 7802
    “…AIF-1 and Swiprosin-1/EFhd2 are already present in Bilateria, for instance in Drosophila melanogaster and Caenhorhabditis elegans. Swiprosin-2/EFhd1 arose later from gene duplication in the tetrapodal lineage. …”
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    Fraternal twins: Swiprosin-1/EFhd2 and Swiprosin-2/EFhd1, two homologous EF-hand containing calcium binding adaptor proteins with distinct functions
  3. 7803
    “…Many of the Ae. aegypti predicted sperm proteins were homologous to Drosophila melanogaster sperm proteins, suggesting conservation of their sperm-related function across Diptera. …”
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    Towards a Semen Proteome of the Dengue Vector Mosquito: Protein Identification and Potential Functions
  4. 7804
    “…BACKGROUND: Genetic studies in Drosophila melanogaster reveal an important role for Myc in controlling growth. …”
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    Drosophila insulin and target of rapamycin (TOR) pathways regulate GSK3 beta activity to control Myc stability and determine Myc expression in vivo
  5. 7805
    “…BACKGROUND: First identified in fruit flies with temperature-sensitive paralysis phenotypes, the Drosophila melanogaster TipE locus encodes four voltage-gated sodium (Na(V)) channel auxiliary subunits. …”
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    A remarkably stable TipE gene cluster: evolution of insect Para sodium channel auxiliary subunits
  6. 7806
    “…The model system Drosophila melanogaster therefore presents an excellent opportunity for the study of alternative splicing due to the availability of quality EST annotations in FlyBase. …”
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    Identification of conserved splicing motifs in mutually exclusive exons of 15 insect species
  7. 7807
    “…We compare the activity of R-Smads from a cnidarian (Nematostella vectensis), an arthropod (Drosophila melanogaster), and a vertebrate (Xenopus laevis) in Xenopus embryonic assays. …”
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    Conservation and evolutionary divergence in the activity of receptor-regulated smads
  8. 7808
    “…A comprehensive analysis was undertaken for promoter sequences from Arabidopsis thaliana, Drosophila melanogaster, Homo sapiens and Oryza sativa, and a more extensive analysis of tissue-specific promoters in humans. …”
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    Eukaryotic genomes may exhibit up to 10 generic classes of gene promoters
  9. 7809
    “…Predicted protein sequences were compared with counterparts in the flour beetle, Tribolium castaneum, the cerambycid beetle, Megacyllene caryae, and the fruit fly, Drosophila melanogaster. The most notable result was found among the ORs, for which large bark beetle-specific expansions were found. …”
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    Antennal transcriptome analysis of the chemosensory gene families in the tree killing bark beetles, Ips typographus and Dendroctonus ponderosae (Coleoptera: Curculionidae: Scolytinae)
  10. 7810
    “…Bateman’s experimental study of Drosophila melanogaster produced conclusions that are now part of the bedrock premises of modern sexual selection. …”
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    Mendel’s law reveals fatal flaws in Bateman’s 1948 study of mating and fitness
  11. 7811
    “…The complete sequence of the 1,267,782 bp genome of Wolbachia pipientis wMel, an obligate intracellular bacteria of Drosophila melanogaster, has been determined. Wolbachia, which are found in a variety of invertebrate species, are of great interest due to their diverse interactions with different hosts, which range from many forms of reproductive parasitism to mutualistic symbioses. …”
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    Phylogenomics of the Reproductive Parasite Wolbachia pipientis wMel: A Streamlined Genome Overrun by Mobile Genetic Elements
  12. 7812
    “…The unique neuronal ancillary subunit TipE-homologous protein 1 of Drosophila melanogaster (DmTEH1) strongly enhances the expression of insect Na(v) channels when heterologously expressed in Xenopus oocytes. …”
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    Intron Retention in mRNA Encoding Ancillary Subunit of Insect Voltage-Gated Sodium Channel Modulates Channel Expression, Gating Regulation and Drug Sensitivity
  13. 7813
    “…RESULTS: Gene ontology annotation based on orthologous relationships with Drosophila melanogaster genes placed the honeybee differentially expressed genes (DEGs) into distinct categories of Biological Process and Molecular Function, depending on developmental time, revealing the functional elements required for adult exoskeleton formation. …”
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    Genes involved in thoracic exoskeleton formation during the pupal-to-adult molt in a social insect model, Apis mellifera
  14. 7814
    “…The Sec-dependent substrate utilization behavior of TR1 may be the exception and not the rule as we show that a variety of high-M(r) TRs from other organisms, including Drosophila melanogaster, Caenorhabditis elegans, and Plasmodium falciparum, do not require Sec to reduce small molecule substrates, including 5,5′-dithiobis(2-nitrobenzoic acid), lipoic acid, selenite, and selenocystine. …”
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    Why Is Mammalian Thioredoxin Reductase 1 So Dependent upon the Use of Selenium?
  15. 7815
    “…RESULTS: We examined functional and evolutionary patterns in the recently constructed set of 5,873 clusters of predicted orthologs (eukaryotic orthologous groups or KOGs) from seven eukaryotic genomes: Caenorhabditis elegans, Drosophila melanogaster, Homo sapiens, Arabidopsis thaliana, Saccharomyces cerevisiae, Schizosaccharomyces pombe and Encephalitozoon cuniculi. …”
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    A comprehensive evolutionary classification of proteins encoded in complete eukaryotic genomes
  16. 7816
    “…Numerous nuclear genes were recently reported in Drosophila melanogaster, which exhibit male-specific patterns of differential expression when placed alongside different mtDNA haplotypes, suggesting that nuclear genes are sensitive to an underlying male-specific mitochondrial mutation load. …”
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    Mito-nuclear interactions as drivers of gene movement on and off the X-chromosome
  17. 7817
    “…Vertebrate (mouse and rat) and invertebrate (Drosophila melanogaster) animal studies for the FMR1 premutation and ovarian function exist and have been instrumental in advancing our understanding of the disease phenotype. …”
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    Use of model systems to understand the etiology of fragile X-associated primary ovarian insufficiency (FXPOI)
  18. 7818
    “…Compared with Drosophila melanogaster, the genome contains a rich resource of shared and novel protein coding genes, a significantly higher amount of repetitive elements, and substantial increases in copy number and diversity of both the recognition and effector components of the immune system, consistent with life in a pathogen-rich environment. …”
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    Genome of the house fly, Musca domestica L., a global vector of diseases with adaptations to a septic environment
  19. 7819
    “…The order Diptera contains two model organisms, the vinegar fly Drosophila melanogaster and the mosquito Anopheles gambiae, whose chemosensory genes have been extensively studied. …”
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    Sex- and tissue-specific profiles of chemosensory gene expression in a herbivorous gall-inducing fly (Diptera: Cecidomyiidae)
  20. 7820
    “…BACKGROUND: During metamorphosis in Drosophila melanogaster, larval muscles undergo two different developmental fates; one population is removed by cell death, while the other persistent subset undergoes morphological remodeling and survives to adulthood. …”
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    FMAj: a tool for high content analysis of muscle dynamics in Drosophila metamorphosis
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