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7861por Gao, Rui, Li, Chun-Lin, Tong, Xiao-Ling, Han, Min-Jin, Lu, Kun-Peng, Liang, Shu-Bo, Hu, Hai, Luan, Yue, Zhang, Bi-Li, Liu, Yan-Yu, Dai, Fang-Yin“…Phylogenetic analysis showed that genes in a subfamily among different animals were well clustered, and the expression pattern of EMEs is constant among Bombyx mori, Drosophila melanogaster, and Mus musculus. These are most highly expressed in brain, early embryo, and internal genitalia. …”
Publicado 2020
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7862por Kolonko, Marta, Bystranowska, Dominika, Taube, Michał, Kozak, Maciej, Bostock, Mark, Popowicz, Grzegorz, Ożyhar, Andrzej, Greb-Markiewicz, Beata“…The Drosophila melanogaster Germ cell-expressed protein (GCE) is a paralog of the juvenile hormone (JH) receptor - Methoprene tolerant protein (MET). …”
Publicado 2020
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7863“…We highlight the conservation of disorder by quantifying the extent of computationally-predicted protein disorder in the core clock of the key eukaryotic circadian model organisms Drosophila melanogaster, Neurospora crassa, and Mus musculus. …”
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7864por Carraretto, Davide, Aketarawong, Nidchaya, Di Cosimo, Alessandro, Manni, Mosè, Scolari, Francesca, Valerio, Federica, Malacrida, Anna R., Gomulski, Ludvik M., Gasperi, Giuliano“…RESULTS: Using Representational Difference Analysis, fluorescent in situ hybridisation on mitotic chromosomes and in silico genome resources, we show that the B. dorsalis Y chromosome harbours transcribed sequences of gyf, (typo-gyf) a homologue of the Drosophila melanogaster Gigyf gene, and of a non-LTR retrotransposon R1. …”
Publicado 2020
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7865por Singgih, Euginia L., van der Voet, Monique, Schimmel-Naber, Marlies, Brinkmann, Emma L., Schenck, Annette, Franke, Barbara“…Here, we tested whether manipulating neuronal expression of cNT5-II orthologues affects neuropsychiatric disorders-related phenotypes in the model organism Drosophila melanogaster. We investigated the brain expression of Drosophila orthologues of cNT5-II family (dNT5A-CG2277, dNT5B-CG32549, and dNT5C-CG1814) using quantitative real-time polymerase chain reaction (qRT-PCR). …”
Publicado 2021
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7866por Ma, Haihao, Yan, Xiumei, Yan, Lin, Zhao, Jingyan, Song, Jiping, Peng, Rong, Yang, Yongbo, Peng, Jianxin, Liu, Kaiyu“…The apoptosis signal pathways are well documented in mammals and Drosophila melanogaster. However, it remains less clear in lepidopteran insects. …”
Publicado 2021
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7867por Catalani, Elisabetta, Bongiorni, Silvia, Taddei, Anna Rita, Mezzetti, Marta, Silvestri, Federica, Coazzoli, Marco, Zecchini, Silvia, Giovarelli, Matteo, Perrotta, Cristiana, De Palma, Clara, Clementi, Emilio, Ceci, Marcello, Prantera, Giorgio, Cervia, Davide“…The analysis of two dystrophic mutants of the fruit fly Drosophila melanogaster, the homozygous Dys(E17) and Dys(EP3397), lacking functional large-isoforms of dystrophin-like protein, revealed rhabdomere degeneration. …”
Publicado 2020
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7868por Jia, Zhihao, Jiang, Shuai, Wang, Mengqiang, Wang, Xiudan, Liu, Yu, Lv, Zhao, Song, Xiaorui, Li, Yiqun, Wang, Lingling, Song, Linsheng“…DM9 refers to an uncharacterized protein domain that is originally discovered in Drosophila melanogaster. Two proteins with DM9 repeats have been recently identified from Pacific oyster Crassostrea gigas as mannose-specific binding pattern-recognition receptors (PRRs). …”
Publicado 2021
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7869por Higareda Alvear, Victor Manuel, Mateos, Mariana, Cortez, Diego, Tamborindeguy, Cecilia, Martinez-Romero, Esperanza“…Spiroplasma poulsonii strain sMel (hereafter Spiroplasma), a male-killing heritable symbiont of Drosophila melanogaster, confers protection against some species of parasitic wasps. …”
Publicado 2021
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7870por Pizzo, Lucilla, Lasser, Micaela, Yusuff, Tanzeen, Jensen, Matthew, Ingraham, Phoebe, Huber, Emily, Singh, Mayanglambam Dhruba, Monahan, Connor, Iyer, Janani, Desai, Inshya, Karthikeyan, Siddharth, Gould, Dagny J., Yennawar, Sneha, Weiner, Alexis T., Pounraja, Vijay Kumar, Krishnan, Arjun, Rolls, Melissa M., Lowery, Laura Anne, Girirajan, Santhosh“…To test this model, we examined how neurodevelopmental defects conferred by knockdown of individual 16p12.1 homologs are modulated by simultaneous knockdown of homologs of “second-hit” genes in Drosophila melanogaster and Xenopus laevis. We observed that knockdown of 16p12.1 homologs affect multiple phenotypic domains, leading to delayed developmental timing, seizure susceptibility, brain alterations, abnormal dendrite and axonal morphology, and cellular proliferation defects. …”
Publicado 2021
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7871Natural abundance isotope ratios to differentiate sources of carbon used during tumor growth in vivo“…IRMS measurements were found to be sufficiently sensitive to measure organs from individual Drosophila melanogaster larvae, giving robust measurements down to 2.5 μg per sample. …”
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7872por Aguilar, Jenny I, Cheng, Mary Hongying, Font, Josep, Schwartz, Alexandra C, Ledwitch, Kaitlyn, Duran, Amanda, Mabry, Samuel J, Belovich, Andrea N, Zhu, Yanqi, Carter, Angela M, Shi, Lei, Kurian, Manju A, Fenollar-Ferrer, Cristina, Meiler, Jens, Ryan, Renae Monique, Mchaourab, Hassane S, Bahar, Ivet, Matthies, Heinrich JG, Galli, Aurelio“…We demonstrate that Drosophila melanogaster expressing hDAT R445C show impaired hDAT activity, which is associated with DA dysfunction in isolated brains and with abnormal behaviors monitored at high-speed time resolution. …”
Publicado 2021
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7873“…BACKGROUND: In the vinegar fly Drosophila melanogaster, the homeodomain containing transcription factor Teashirt (Tsh) appears to specify trunk identity in concert with the function of the Hox genes. …”
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7874por Marot-Lassauzaie, Valérie, Goldberg, Tatyana, Armenteros, Jose Juan Almagro, Nielsen, Henrik, Rost, Burkhard“…This work compared the location spectra for ten eukaryotes: Homo sapiens (human), Gorilla gorilla (gorilla), Pan troglodytes (chimpanzee), Mus musculus (mouse), Rattus norvegicus (rat), Drosophila melanogaster (fruit/vinegar fly), Anopheles gambiae (African malaria mosquito), Caenorhabitis elegans (nematode), Saccharomyces cerevisiae (baker’s yeast), and Schizosaccharomyces pombe (fission yeast). …”
Publicado 2021
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7875por Slavik, Kailey M., Morehouse, Benjamin R., Ragucci, Adelyn E., Zhou, Wen, Ai, Xianlong, Chen, Yuqiang, Li, Lihua, Wei, Ziming, Bähre, Heike, König, Martin, Seifert, Roland, Lee, Amy S. Y., Cai, Hua, Imler, Jean-Luc, Kranzusch, Philip J.“…We demonstrate that surface remodelling of cGLRs enables altered ligand specificity and used a forward biochemical screen to identify cGLR1 as a double-stranded RNA sensor in the model organism Drosophila melanogaster. We show that RNA recognition activates Drosophila cGLR1 to synthesize the novel product cG[3′–5′]pA[2′–5′]p (3′2′-cGAMP). …”
Publicado 2021
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7876por Driscoll, Margaret, Buchert, Steven N, Coleman, Victoria, McLaughlin, Morgan, Nguyen, Amanda, Sitaraman, Divya“…The fruit fly, Drosophila melanogaster, provides a powerful model system for the study of sleep and circuit mechanisms underlying state transitions and persistence of states to meet the organisms motivational and cognitive needs. …”
Publicado 2021
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7877por Landis, Gary N., Hilsabeck, Tyler A. U., Bell, Hans S., Ronnen-Oron, Tal, Wang, Lu, Doherty, Devon V., Tejawinata, Felicia I., Erickson, Katherine, Vu, William, Promislow, Daniel E. L., Kapahi, Pankaj, Tower, John“…We previously reported that mifepristone blocks the negative effect on life span caused by mating in female Drosophila melanogaster. Methods: Here we asked if mifepristone could protect virgin females from the life span-shortening effect of HFD. …”
Publicado 2021
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7878“…Throughout the experiment, we collected data from 7 species, including Homo sapiens, Mus musculus, Drosophila melanogaster, Arabidopsis thaliana, Kluyveromyces lactis, Pichia pastoris and Schizosaccharomyces pombe. …”
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7879por Klöppel, Christine, Hildebrandt, Kirsten, Kolb, Dieter, Fürst, Nora, Bley, Isabelle, Karlowatz, Ruth-Jessica, Walldorf, Uwe“…Many transcriptional activators are involved in formation of the brain during the development of Drosophila melanogaster. The transcription factor Drosophila Retinal homeobox (DRx), a member of the 57B homeobox gene cluster, is also one of these factors for brain development. …”
Publicado 2021
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7880por Huggett, Spencer B., Hatfield, Jeffrey S., Walters, Joshua D., McGeary, John E., Welsh, Justine W., Mackay, Trudy F. C., Anholt, Robert R. H., Palmer, Rohan H. C.“…We assessed the therapeutic efficacy of ibrutinib using the Drosophila melanogaster model. Ibrutinib reduced cocaine-induced startle response and cocaine-induced seizures (n = 61–142 per group; sex: 51% female), despite increasing cocaine consumption. …”
Publicado 2021
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