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  1. 7881
    “…Notably, ALK activation in neurons impaired Stx17-dependent autophagosome maturation and this defect was reversed by a dominant-negative Grb2. In a Drosophila melanogaster model, transgenic flies neuronally expressing active Drosophila Alk exhibited the aggravated tau rough eye phenotype with retinal degeneration and shortened lifespan. …”
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    Aberrant role of ALK in tau proteinopathy through autophagosomal dysregulation
  2. 7882
    “…Dcr2 contains several domains crucial for its activities, including helicase and RNase III domains. In Drosophila melanogaster Dcr2, the helicase domain has been associated with binding to dsRNA with blunt-ended termini and a processive siRNA production mechanism, while the platform-PAZ domains bind dsRNA with 3’ overhangs and subsequent distributive siRNA production. …”
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    Mutational analysis of Aedes aegypti Dicer 2 provides insights into the biogenesis of antiviral exogenous small interfering RNAs
  3. 7883
    “…Twenty-two microRNAs with 56 experimentally validated target genes in the closely related Drosophila melanogaster were identified. Thus, the microRNA found display the unique evolution of BSF, along with the life stages and potential genes to target for robust mass rearing. …”
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    microRNA profile of Hermetia illucens (black soldier fly) and its implications on mass rearing
  4. 7884
    “…ABSTRACT: Fushi Tarazu Factor 1 (FTZ-F1), a member of the nuclear receptor superfamily, is the downstream factor of 20-hydroxyecdysone signaling. In Drosophila melanogaster, alternative transcription start and splicing in the FTZ-F1 gene generate αFTZ-F1 and βFTZ-F1 isoforms, which are vital for pair-rule segmentation in early embryogenesis and post-embryonic development, respectively. …”
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    Dissecting the Isoform-Specific Roles of FTZ-F1 in the Larval–Larval and Larval–Pupal Ecdyses in Henosepilachna vigintioctopunctata
  5. 7885
    “…We have previously shown that overexpression of Drosophila melanogaster uL11 enhances the transcription of many RPGs and Ribosomal Biogenesis genes (RiBis) suggesting that uL11 might globally regulate the level of translation through its transcriptional activity. …”
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    Single amino-acid mutation in a Drosoph ila melanogaster ribosomal protein: An insight in uL11 transcriptional activity
  6. 7886
    “…We previously showed that inserting this mutation into Drosophila melanogaster indirect flight muscle myosin yields mechanical and locomotory defects. …”
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    Myosin Transducer Inter-Strand Communication Is Critical for Normal ATPase Activity and Myofibril Structure
  7. 7887
    “…We predicted potential protein-coding gene regions associated with these transcripts in G. m. morsitans genome, annotated/curated these genes and identified their putative annotated orthologs/homologs in Drosophila melanogaster, Musca domestica or Anopheles gambiae genomes. …”
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    Annotations of novel antennae-expressed genes in male Glossina morsitans morsitans tsetse flies
  8. 7888
    “…BACKGROUND: The nose of most animals comprises multiple sensory subsystems, which are defined by the expression of different olfactory receptor families. Drosophila melanogaster antennae contain two morphologically and functionally distinct subsystems that express odorant receptors (Ors) or ionotropic receptors (Irs). …”
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    Pheromone sensing in Drosophila requires support cell-expressed Osiris 8
  9. 7889
    “…Here, we studied the parasitic wasp Leptopilina boulardi (Lb) and its host Drosophila melanogaster. Results showed that Lb successfully develops in conventional hosts (CN) with a gut microbiota but fails to develop in axenic hosts (AX) without a gut microbiota. …”
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    Parasite reliance on its host gut microbiota for nutrition and survival
  10. 7890
    “…For example, a system of paramutation in Drosophila melanogaster has been shown to be mediated by piRNAs, whose primary function is to silence transposable elements in the germline. …”
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    Paramutation-like Epigenetic Conversion by piRNA at the Telomere of Drosophila virilis
  11. 7891
    “…After acute injury in muscle of both mouse and the fruit fly Drosophila melanogaster (used as alternative in vivo model) we found that RACK1 accumulated in regenerating fibers while it declined with the progression of repair process. …”
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    RACK1 is evolutionary conserved in satellite stem cell activation and adult skeletal muscle regeneration
  12. 7892
    “…In order to understand the consequences of mutations in TRPC6 on nervous system function, we used the fruit fly, Drosophila melanogaster, to show that null mutations in transient receptor gamma (trpγ; the fly gene most similar to TRPC6), cause a number of behavioral defects that mirror features seen in ASD patients, including deficits in social interactions (based on courtship behavior), impaired sleep homeostasis (without affecting the circadian control of sleep), hyperactivity in both young and old flies, and defects in learning and memory. …”
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    Mutations in trpγ, the homologue of TRPC6 autism candidate gene, causes autism-like behavioral deficits in Drosophila
  13. 7893
    “…RESULTS: In this study, we utilized the natural variation present in multiple populations of Drosophila melanogaster collected across Europe to screen for variation in copper tolerance. …”
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    The genomic basis of copper tolerance in Drosophila is shaped by a complex interplay of regulatory and environmental factors
  14. 7894
    “…Together, these data suggested that DrDprA is largely structurally conserved with other DprA homologs but shows some unique structure-function features like the existence of an additional C-terminal Drosophila melanogaster Miasto-like protein 1 (DML1) domain, equal affinities for ssDNA and dsDNA, and the collective roles of oligomerization and DNA binding properties in supporting DrRecA functions. …”
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    Characterization of DNA Processing Protein A (DprA) of the Radiation-Resistant Bacterium Deinococcus radiodurans
  15. 7895
    “…The ellipsoid body (EB) is a major structure of the central complex of the Drosophila melanogaster brain. Twenty-two subtypes of EB ring neurons have been identified based on anatomic and morphologic characteristics by light-level microscopy and EM connectomics. …”
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    Subtype-Specific Roles of Ellipsoid Body Ring Neurons in Sleep Regulation in Drosophila
  16. 7896
    “…Saprophytic drosophilid puparia (=SD) belonging to the Drosophila melanogaster group and SWD were found in all tested microhabitats. …”
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    Implications of the Niche Partitioning and Coexistence of Two Resident Parasitoids for Drosophila suzukii Management in Non-Crop Areas
  17. 7897
    “…However, there are examples of non-canonical telomeres among eukaryotes where telomeric tandem repeats are invaded by specific retrotransposons. Drosophila melanogaster represents an extreme example with telomeres composed solely by three retrotransposons—Het-A, TAHRE and TART (HTT). …”
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    Telomeric retrotransposons show propensity to form G-quadruplexes in various eukaryotic species
  18. 7898
    “…We next performed functional studies on the disease-associated variants in cultured cells and knock-down of ptpa in Drosophila melanogaster. We first identified a homozygous PTPA variant, c.893T>G (p.Met298Arg), in patients from a South African family with early-onset parkinsonism and intellectual disability. …”
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    PTPA variants and impaired PP2A activity in early-onset parkinsonism with intellectual disability
  19. 7899
    “…Taking advantage of the Gal4‐UAS system, we used the Drosophila melanogaster wing imaginal disc as an in vivo model to study the regulation of Plin2 proteostasis and LD homeostasis. …”
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    Identification of Ubr1 as an amino acid sensor of steatosis in liver and muscle
  20. 7900
    por Malhotra, Pooja, Basu, Saumik
    Publicado 2023
    “…The mechanism of ETH function on ecdysis has been well investigated in holometabolous insects such as moths Manduca sexta and Bombyx mori, fruit fly Drosophila melanogaster, the yellow fever mosquito Aedes aegypti and beetle Tribolium castaneum etc. …”
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    The Intricate Role of Ecdysis Triggering Hormone Signaling in Insect Development and Reproductive Regulation
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