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  1. 7981
    por Scheffer, Louis K, Xu, C Shan, Januszewski, Michal, Lu, Zhiyuan, Takemura, Shin-ya, Hayworth, Kenneth J, Huang, Gary B, Shinomiya, Kazunori, Maitlin-Shepard, Jeremy, Berg, Stuart, Clements, Jody, Hubbard, Philip M, Katz, William T, Umayam, Lowell, Zhao, Ting, Ackerman, David, Blakely, Tim, Bogovic, John, Dolafi, Tom, Kainmueller, Dagmar, Kawase, Takashi, Khairy, Khaled A, Leavitt, Laramie, Li, Peter H, Lindsey, Larry, Neubarth, Nicole, Olbris, Donald J, Otsuna, Hideo, Trautman, Eric T, Ito, Masayoshi, Bates, Alexander S, Goldammer, Jens, Wolff, Tanya, Svirskas, Robert, Schlegel, Philipp, Neace, Erika, Knecht, Christopher J, Alvarado, Chelsea X, Bailey, Dennis A, Ballinger, Samantha, Borycz, Jolanta A, Canino, Brandon S, Cheatham, Natasha, Cook, Michael, Dreher, Marisa, Duclos, Octave, Eubanks, Bryon, Fairbanks, Kelli, Finley, Samantha, Forknall, Nora, Francis, Audrey, Hopkins, Gary Patrick, Joyce, Emily M, Kim, SungJin, Kirk, Nicole A, Kovalyak, Julie, Lauchie, Shirley A, Lohff, Alanna, Maldonado, Charli, Manley, Emily A, McLin, Sari, Mooney, Caroline, Ndama, Miatta, Ogundeyi, Omotara, Okeoma, Nneoma, Ordish, Christopher, Padilla, Nicholas, Patrick, Christopher M, Paterson, Tyler, Phillips, Elliott E, Phillips, Emily M, Rampally, Neha, Ribeiro, Caitlin, Robertson, Madelaine K, Rymer, Jon Thomson, Ryan, Sean M, Sammons, Megan, Scott, Anne K, Scott, Ashley L, Shinomiya, Aya, Smith, Claire, Smith, Kelsey, Smith, Natalie L, Sobeski, Margaret A, Suleiman, Alia, Swift, Jackie, Takemura, Satoko, Talebi, Iris, Tarnogorska, Dorota, Tenshaw, Emily, Tokhi, Temour, Walsh, John J, Yang, Tansy, Horne, Jane Anne, Li, Feng, Parekh, Ruchi, Rivlin, Patricia K, Jayaraman, Vivek, Costa, Marta, Jefferis, Gregory SXE, Ito, Kei, Saalfeld, Stephan, George, Reed, Meinertzhagen, Ian A, Rubin, Gerald M, Hess, Harald F, Jain, Viren, Plaza, Stephen M
    Publicado 2020
    “…We summarize new methods and present the circuitry of a large fraction of the brain of the fruit fly Drosophila melanogaster. Improved methods include new procedures to prepare, image, align, segment, find synapses in, and proofread such large data sets. …”
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    A connectome and analysis of the adult Drosophila central brain
  2. 7982
    “…However, homologs of putative RNAi spreading defective-3 (Rsd-3) protein and scavenger receptors namely Eater and SR-CI that mediate endocytosis cellular update of dsRNA in C. elegans and Drosophila melanogaster were found in Acari genomes. This result suggests that cellular dsRNA uptake in Acari is endocytosis-dependent. …”
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    A genome-wide screening for RNAi pathway proteins in Acari
  3. 7983
    “…Protein sequence, the presence and number of conserved CAP-domains and phylogeny were used to group identified SCP/TAPS proteins; these were compared to those found in Drosophila melanogaster to make functional predictions. In addition, transcription levels of SCP/TAPS protein-encoding genes were explored in different developmental stages. …”
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    Major SCP/TAPS protein expansion in Lucilia cuprina is associated with novel tandem array organisation and domain architecture
  4. 7984
    “…The Model Organism Screening Center (MOSC) of the UDN is a unique resource dedicated to utilizing informatics and functional studies in model organisms, including worm (Caenorhabditis elegans), fly (Drosophila melanogaster), and zebrafish (Danio rerio), to aid in diagnosis. …”
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    Model organisms contribute to diagnosis and discovery in the undiagnosed diseases network: current state and a future vision
  5. 7985
    “…BACKGROUND: Most insects are relatively short-lived, with a maximum lifespan of a few weeks, like the aging model organism, the fruit-fly Drosophila melanogaster. By contrast, the queens of many social insects (termites, ants and some bees) can live from a few years to decades. …”
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    Disentangling the aging gene expression network of termite queens
  6. 7986
    “…We knocked hαSyn(TP) or hαSyn(Δ119) (h stands for “human”) into the murine αSyn locus. hαSyn(TP) is a structure-based mutant with triple alanine to proline substitutions that favors oligomers, is neurotoxic and evokes PD-like symptoms in Drosophila melanogaster. hαSyn(Δ119) lacks 21 amino acids at the C-terminus, favors fibrillary aggregates and occurs in PD. …”
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    Low-Expressing Synucleinopathy Mouse Models Based on Oligomer-Forming Mutations and C-Terminal Truncation of α-Synuclein
  7. 7987
    “…Here, taking advantage of the genetically accessible adult Drosophila melanogaster intestine and the availability of ex vivo single cell sequencing data, we tested that hypothesis and investigated the metabolism of the intestinal lineage from stem cell (ISC) to differentiated epithelial cell in their native context under homeostatic conditions. …”
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    The MicroRNA miR-277 Controls Physiology and Pathology of the Adult Drosophila Midgut by Regulating the Expression of Fatty Acid β-Oxidation-Related Genes in Intestinal Stem Cells
  8. 7988
    “…The results of a comparative analysis of antibiotic-resistant and parental strains indicate that the development of resistance to the corresponding antimicrobial drugs in L. plantarum in vitro is accompanied by the following: (i) significant changes in the genomic profile (point mutations as well as deletions, insertions, duplications, and displacement of DNA sequences) associated in part with the resistome and mobilome; (ii) changes in phenotypic sensitivity to a number of antimicrobial drugs; and (iii) an increase in the level of virulence against Drosophila melanogaster, a model organism for which L. plantarum is considered to be a symbiont. …”
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    Development of Resistance to Clarithromycin and Amoxicillin-Clavulanic Acid in Lactiplantibacillus plantarum In Vitro Is Followed by Genomic Rearrangements and Evolution of Virulence
  9. 7989
    “…Although this is not practical for most model organisms, it is potentially possible in Drosophila melanogaster, where collections of timed and yet somewhat asynchronous embryos are easy to obtain, such that, at least in principle, one can achieve arbitrarily high temporal resolution. …”
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    The continuum of Drosophila embryonic development at single-cell resolution
  10. 7990
    “…We investigated effects of IASC and IRSC on two aspects of somatic investment, immune defence strategies and longevity, using previously established female-limited experimental evolution lines in Drosophila melanogaster. We found little evidence for any effect of either type of sexual conflict on investment in the immune defence resistance or tolerance. …”
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    Female-limited X chromosome evolution reveals that lifespan is mainly modulated by interlocus rather than intralocus sexual conflict
  11. 7991
    “…We report NUP93 cases in the UK and demonstrate in vivo functional effects of Nup93 depletion in a fly (Drosophila melanogaster) nephrocyte model. METHODS: Three hundred thirty-seven paediatric SRNS patients from the National cohort of patients with Nephrotic Syndrome (NephroS) were whole exome and/or whole genome sequenced. …”
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    Exploring the relevance of NUP93 variants in steroid-resistant nephrotic syndrome using next generation sequencing and a fly kidney model
  12. 7992
    por Ruden, Douglas M.
    Publicado 2022
    “…Ruden’s laboratory and titled, “Using Drosophila melanogaster as a model for genotoxic chemical mutational studies with a new program, SnpSift.” …”
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    10 Years of Toxicogenomics section in Frontiers in Genetics: Past discoveries and Future Perspectives
  13. 7993
    “…Therefore, we evaluated different dissociation protocols to obtain single cells from small tissue samples of Drosophila melanogaster eye-antennal imaginal discs. RESULTS: We show that a combination of mechanical and chemical dissociation resulted in sufficient high-quality cells. …”
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    Tissue dissociation for single-cell and single-nuclei RNA sequencing for low amounts of input material
  14. 7994
    “…We annotated P. auratus transcripts using Homo sapiens and Drosophila melanogaster genes as references; 50.5% of P. auratus transcripts were assigned to H. sapiens genes, and 54.0% of P. auratus transcripts were assigned to D. melanogaster genes. …”
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    Nutritional and metabolic process of the dung beetle Phelotrupes auratus depends on the plant ingredients that the herbivores eat
  15. 7995
    “…Other studies in humans also show that both sleep quantity and sleep quality decrease with age. Drosophila melanogaster is a useful model to study aging and sleep, and inheriting mutations affecting the potassium current Shaker results in flies that sleep less and have a shorter lifespan. …”
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    Sleep, aging, and lifespan in Drosophila
  16. 7996
    “…Its genome also contains 2.1-fold more duplicated genes and 1.4-fold more single copy genes than the Drosophila melanogaster genome. The Nasonia gene count is larger than those of other sequenced hymenopteran species, owing both to improvements in the genome annotation and to unique genes in the wasp lineage. …”
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    OGS2: genome re-annotation of the jewel wasp Nasonia vitripennis
  17. 7997
    “…Finally, the profiling of a Drosophila melanogaster microbiome using the set of six primer pairs provided a ~ 100-fold increase in resolution and thus enabling efficient downstream analysis. …”
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    Combining 16S rRNA gene variable regions enables high-resolution microbial community profiling
  18. 7998
    por Abi-Dargham, Anissa
    Publicado 2018
    “…He demonstrated these dysfunctions in brains of Drosophila melanogaster expressing hDAT ∆N336. Furthermore, these flies are hyperactive and display fear and impaired social interactions, traits associated with impaired DA neurotransmission. …”
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    27. THE ROLE OF DOPAMINE IN SHAPING CIRCUITRY RELATED TO SCHIZOPHRENIA AND ADDICTION
  19. 7999
    por Konrad, Enrico D. H., Nardini, Niels, Caliebe, Almuth, Nagel, Inga, Young, Dana, Horvath, Gabriella, Santoro, Stephanie L., Shuss, Christine, Ziegler, Alban, Bonneau, Dominique, Kempers, Marlies, Pfundt, Rolph, Legius, Eric, Bouman, Arjan, Stuurman, Kyra E., Õunap, Katrin, Pajusalu, Sander, Wojcik, Monica H., Vasileiou, Georgia, Le Guyader, Gwenaël, Schnelle, Hege M., Berland, Siren, Zonneveld-Huijssoon, Evelien, Kersten, Simone, Gupta, Aditi, Blackburn, Patrick R., Ellingson, Marissa S., Ferber, Matthew J., Dhamija, Radhika, Klee, Eric W., McEntagart, Meriel, Lichtenbelt, Klaske D., Kenney, Amy, Vergano, Samantha A., Abou Jamra, Rami, Platzer, Konrad, Ella Pierpont, Mary, Khattar, Divya, Hopkin, Robert J., Martin, Richard J., Jongmans, Marjolijn C. J., Chang, Vivian Y., Martinez-Agosto, Julian A., Kuismin, Outi, Kurki, Mitja I., Pietiläinen, Olli, Palotie, Aarno, Maarup, Timothy J., Johnson, Diana S., Venborg Pedersen, Katja, Laulund, Lone W., Lynch, Sally A., Blyth, Moira, Prescott, Katrina, Canham, Natalie, Ibitoye, Rita, Brilstra, Eva H., Shinawi, Marwan, Fassi, Emily, Sticht, Heinrich, Gregor, Anne, Van Esch, Hilde, Zweier, Christiane
    Publicado 2019
    “…We performed transcriptome analysis on RNA from blood samples and utilized Drosophila melanogaster to investigate the impact of Ctcf dosage alteration on nervous system development and function. …”
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    CTCF variants in 39 individuals with a variable neurodevelopmental disorder broaden the mutational and clinical spectrum
  20. 8000
    “…METHODS: We produced the first models of myosin-based DA1 (F437I) and DA2B (A234T) using transgenic Drosophila melanogaster and performed an integrative analysis of the effects of the mutations. …”
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    Drosophila myosin mutants model the disparate severity of type 1 and type 2B distal arthrogryposis and indicate an enhanced actin affinity mechanism
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