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Mostrando 181 - 200 Resultados de 1,929 Para Buscar '"Dub"', tiempo de consulta: 0.15s Limitar resultados
  1. 181
    “…Little is known about the demographic and clinical differences between short and long duration of untreated bipolar disorder (DUB) in Chinese patients. This study examined the demographic and clinical features of short (≤2 years) and long DUB (>2 years) in China. …”
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    Duration of untreated bipolar disorder: a multicenter study
  2. 182
    “…The present study sought to assess the magnitude of duration of untreated bipolar disorder (DUB) in Brazil. We hypothesized that DUB would be longer in Brazil than in developed countries, and would be associated with poor clinical outcomes. …”
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    Association between duration of untreated bipolar disorder and clinical outcome: data from a Brazilian sample
  3. 183
    “…Introducing a single-point mutation in TYMV PRO/DUB aimed at improving ubiquitin-binding led to a much more active DUB. …”
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    Turnip yellow mosaic virus protease binds ubiquitin suboptimally to fine-tune its deubiquitinase activity
  4. 184
    “…Two groups were vaccinated, either with DUB-positive (n = 9) or DUB-negative (n = 9) recombinant EAV. …”
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    In vivo assessment of equine arteritis virus vaccine improvement by disabling the deubiquitinase activity of papain-like protease 2
  5. 185
    “…These studies provide a framework for dissecting DUB signaling pathways in S. pombe and may shed light on DUB functions in metazoans.…”
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    A Global Census of Fission Yeast Deubiquitinating Enzyme Localization and Interaction Networks Reveals Distinct Compartmentalization Profiles and Overlapping Functions in Endocytosis and Polarity
  6. 186
    “…The subsequent mutagenesis analyses revealed that the requirement for PLP2 DUB activity surprisingly resembled that for cis-cleavage activity, as several mutations (e.g., D91R, D85R, etc.) that largely ablated the DUB function also blocked the cis- but not trans-proteolytic cleavage of nsp2/3 polyprotein. …”
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    Characterizing the PRRSV nsp2 Deubiquitinase Reveals Dispensability of Cis-Activity for Replication and a Link of nsp2 to Inflammation Induction
  7. 187
    “…However, the influence of DUb on CRC remains unclear. Herein, we found that DUb significantly inhibited CRC growth in the patient-derived xenograft (PDX) and CT26 xenograft models. …”
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    Decylubiquinone Inhibits Colorectal Cancer Growth Through Upregulating Sirtuin2
  8. 188
    “…DUb-TSG101 had no effect on budding of MoMLV or EIAV, two retroviruses that rely on the ESCRT machinery for exit. …”
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    Ubiquitin conjugation to Gag is essential for ESCRT-mediated HIV-1 budding
  9. 189
    “…Therefore, dissecting the underlying mechanism of DUB recognition is needed to advance the development of drugs related to DUB signaling pathways. …”
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    Deubiquitination complex platform: A plausible mechanism for regulating the substrate specificity of deubiquitinating enzymes
  10. 190
    “…M48 DUB activity also influences MCK2 incorporation into virions. …”
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    Murine Cytomegalovirus Deubiquitinase Regulates Viral Chemokine Levels To Control Inflammation and Pathogenesis
  11. 191
    “…We characterize the DUB activity of eight Simkania-encoded enzymes belonging to five different DUB classes. …”
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    Functional and structural diversity in deubiquitinases of the Chlamydia-like bacterium Simkania negevensis
  12. 192
    “…Results show that we can selectively modulate DUB activity at amino acid positions 1649 and 1653 while mutation of Val1691 or His1652 of PLpro to a positive charged residue completely impairs both DUB/deISG activities. …”
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    Decoupling deISGylating and deubiquitinating activities of the MERS virus papain-like protease
  13. 193
    “…Coronaviruses express a papain-like protease (PLpro) that is required for replicase polyprotein maturation and also serves as a deubiquitinating enzyme (DUB). In this study, using a Middle East respiratory syndrome virus (MERS-CoV) PLpro modified virus in which the DUB is selectively inactivated, we show that the PLpro DUB is an important MERS-CoV interferon antagonist and virulence factor. …”
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    Engineering potent live attenuated coronavirus vaccines by targeted inactivation of the immune evasive viral deubiquitinase
  14. 194
    “…The human genome contains nearly 100 deubiquitinating enzymes (DUBs) responsible for removing ubiquitin moieties from a large variety of substrates. …”
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    A Proteomic Approach for Systematic Mapping of Substrates of Human Deubiquitinating Enzymes
  15. 195
    por Skelly, Michael J., Spoel, Steven H.
    Publicado 2021
    “…Understanding how DUBs function in vitro is a vital first step to uncovering their cellular roles. …”
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    Characterising Plant Deubiquitinases with in vitro Activity-based Labelling and Ubiquitin Chain Disassembly Assays
  16. 196
    “…Identification of selective deubiquitinase (DUB) inhibitors is critical for probe development to further understand and explore DUB biological function. …”
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    Identification of deubiquitinase inhibitors via high-throughput screening using a fluorogenic ubiquitin-rhodamine assay
  17. 197
    por Harrigan, Jeanine, Jacq, Xavier
    Publicado 2016
    “…Deubiquitylating enzymes or DUBs are a class of enzymes that selectively remove the polypeptide posttranslational modification ubiquitin from a number of substrates. …”
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    Monitoring Target Engagement of Deubiquitylating Enzymes Using Activity Probes: Past, Present, and Future
  18. 198
    “…In yeast, we predict 85 UBE and 24 DUB genes, for 814 UBE and 107 DUB genes in the human genome. …”
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    The Repertoires of Ubiquitinating and Deubiquitinating Enzymes in Eukaryotic Genomes
  19. 199
    “…LotA is unique among other OTU DUBs because it possesses two distinct DUB domains and exclusively exhibits catalytic activity against K6-linked diUb and polyUb chains. …”
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    Structural basis for the dual catalytic activity of the Legionella pneumophila ovarian tumor (OTU) domain deubiquitinase LotA
  20. 200
    “…Here we reported on mitigation of type I interferon (IFN) production by EBV deubiquitinase (DUB) BPLF1 through cGAS-STING and RIG-I-MAVS pathways. …”
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    Suppression of cGAS- and RIG-I-mediated innate immune signaling by Epstein-Barr virus deubiquitinase BPLF1
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