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Mostrando 201 - 220 Resultados de 1,929 Para Buscar '"Dub"', tiempo de consulta: 0.22s Limitar resultados
  1. 201
    “…Deubiquitinating enzymes (DUBs) constitute a diverse protein family and their impact on numerous biological and pathological processes has now been widely appreciated. …”
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    PTMs in Conversation: Activity and Function of Deubiquitinating Enzymes Regulated via Post-Translational Modifications
  2. 202
    “…DUB activity was necessary for inflammasome association as DUB inhibition also impaired ASC oligomerization and caspase-1 activation without directly blocking caspase-1 activity. …”
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    Deubiquitinases Regulate the Activity of Caspase-1 and Interleukin-1β Secretion via Assembly of the Inflammasome
  3. 203
    “…BACKGROUND: The term dysfunctional uterine bleeding (DUB) refers to any abnormal bleeding from the uterus, unassociated with tumour, inflammation and pregnancy. …”
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    Clinco-Pathological Patterns in Women with Dysfunctional Uterine Bleeding
  4. 204
    “…The removal of ubiquitin from its target protein is catalyzed by deubiquitinating enzymes (DUBs). Although it was proposed that many DUBs specifically interact and recognize ubiquitinated proteins as substrates, more direct evidence is needed to support this notion. …”
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    Activity-based ubiquitin-protein probes reveal target protein specificity of deubiquitinating enzymes
  5. 205
    “…Inhibition of DUB activity does not affect elongation of RNA synthesis, and inhibition of RNA synthesis does not affect DUB activity. …”
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    Independent inhibition of the polymerase and deubiquitinase activities of the Crimean-Congo Hemorrhagic Fever Virus full-length L-protein
  6. 206
    “…A common strategy for exploring the biological roles of deubiquitinating enzymes (DUBs) in different pathways is to study the effects of replacing the wild‐type DUB with a catalytically inactive mutant in cells. …”
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    Active site alanine mutations convert deubiquitinases into high‐affinity ubiquitin‐binding proteins
  7. 207
    “…The ability to decouple the DUB activity of PL(pro) from its role in viral polyprotein processing now provides an approach to further dissect the role(s) of PL(pro) as a viral DUB during MERS-CoV infection.…”
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    Crystal Structure of the Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Papain-like Protease Bound to Ubiquitin Facilitates Targeted Disruption of Deubiquitinating Activity to Demonstrate Its Role in Innate Immune Suppression
  8. 208
    “…Deubiquitinating enzymes (DUBs) regulate ubiquitin signaling by trimming ubiquitin chains or removing ubiquitin from modified substrates. …”
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    A family of unconventional deubiquitinases with modular chain specificity determinants
  9. 209
    “…Attachment of ubiquitin to lysine 119 of Histone 2A (H2AK119Ub) is an epigenetic mark characteristic of repressed developmental genes, which is removed by the Polycomb Repressive-Deubiquitinase (PR-DUB) complex. Here we report the crystal structure of the Drosophila PR-DUB, revealing that the deubiquitinase Calypso and its activating partner ASX form a 2:2 complex. …”
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    A bidentate Polycomb Repressive-Deubiquitinase complex is required for efficient activity on nucleosomes
  10. 210
    “…The co-crystal structure of the DUB (OtDUB) domain with ubiquitin revealed three bound ubiquitins: one engages the S1 site, the second binds an S2 site contributing to chain specificity and the third binds a unique ubiquitin-binding domain (UBD). …”
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    A deubiquitylase with an unusually high-affinity ubiquitin-binding domain from the scrub typhus pathogen Orientia tsutsugamushi
  11. 211
    “…Activity-based protein profiling of L. mexicana C12, C19 and C65 deubiquitinating cysteine peptidases (DUBs) revealed DUB activity remains relatively constant during differentiation of procyclic promastigote to amastigote. …”
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    Essential roles for deubiquitination in Leishmania life cycle progression
  12. 212
    “…We generated Brcc36 deubiquitylating enzyme (DUB) inactive mice to address this gap in knowledge in a physiologic system. …”
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    Autologous K63 deubiquitylation within the BRCA1-A complex licenses DNA damage recognition
  13. 213
    “…Several viruses have been found to encode a deubiquitinating protease (DUB). These viral DUBs are proposed to play a role in regulating innate immune or inflammatory signaling. …”
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    Cooperative inhibition of RIP1-mediated NF-κB signaling by cytomegalovirus-encoded deubiquitinase and inactive homolog of cellular ribonucleotide reductase large subunit
  14. 214
    “…Despite a growing understanding of DUB biology at the structural and molecular level, little is known about the physiological importance of most DUBs. …”
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    Systematic Analysis of the Physiological Importance of Deubiquitinating Enzymes
  15. 215
    por Skelly, Michael J.
    Publicado 2022
    “…This review focuses on the most recent findings in plant DUB biology, particularly on newly identified DUB substrates and how these offer clues to the wide-ranging roles that DUBs play in the cell. …”
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    The emerging roles of deubiquitinases in plant proteostasis
  16. 216
    “…Importantly, mutations that alter DUB activity but not viral protease activity have been identified and arteriviruses expressing DUB mutants stimulated higher levels of acute inflammatory cytokines after infection. …”
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    Nidovirus papain-like proteases: Multifunctional enzymes with protease, deubiquitinating and deISGylating activities
  17. 217
    “…We utilized a DUB siRNA library to identify the ovarian tumor protease (OTU) family member deubiquitinase YOD1 as a critical DUB of PML/RARα. …”
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    Blockade of deubiquitinase YOD1 degrades oncogenic PML/RARα and eradicates acute promyelocytic leukemia cells
  18. 218
    “…METHODS: A total of 98 DUB patients were enrolled in this case–control study. …”
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    Decreased expression of survivin, estrogen and progesterone receptors in endometrial tissues after radiofrequency treatment of dysfunctional uterine bleeding
  19. 219
    por Mehrabian, Ferdous, Abbassi, Fariba
    Publicado 2013
    “…One hundred women who presented with DUB were randomly assigned into two groups of equal number, receiving the low dose oral contraceptive pills by oral or vaginal route for three month. …”
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    Comparing the effects of low-dose contraceptive pills to control dysfunctional uterine bleeding by oral and vaginal methods
  20. 220
    por Baxi, Seema N., Panchal, Nirav S.
    Publicado 2015
    “…Only few studies have used cytology in the diagnosis of dysfunctional uterine bleeding (DUB). Endometrial imprint cytology has been rarely used except for application of immunocytochemistry in diagnosis of endometrial carcinoma. …”
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    Histopathology-like categories based on endometrial imprint cytology in dysfunctional uterine bleeding
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