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Mostrando 241 - 260 Resultados de 1,929 Para Buscar '"Dub"', tiempo de consulta: 0.30s Limitar resultados
  1. 241
    “…Finally, we show that this DUB activity contributes to viral infectivity in plant cells. …”
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    A viral deubiquitylating enzyme targets viral RNA-dependent RNA polymerase and affects viral infectivity
  2. 242
    “…Deubiquitinating enzymes (DUBs) are important regulators of the posttranslational protein ubiquitination system. …”
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    An evolutionary approach to systematic discovery of novel deubiquitinases, applied to Legionella
  3. 243
    por Kim, Hyo Jin, Kim, Jongchan
    Publicado 2021
    “…Through pull-down assays with the human DUB library, we identified OTUD6A as an Aurora-A-specific DUB. …”
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    OTUD6A Is an Aurora Kinase A-Specific Deubiquitinase
  4. 244
    “…Deubiquitinases (DUBs) have been the subject of intense scrutiny in recent years. …”
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    On the Study of Deubiquitinases: Using the Right Tools for the Job
  5. 245
    “…This study provides new indications for further mechanism research of HH on DUB and the development of HH or its components as an alternative therapy for patients with DUB. …”
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    Identification and verification of effective components of Huanghuai for dysfunctional uterine bleeding based on network pharmacology and molecular docking
  6. 246
    “…[Image: see text] Deubiquitinylating enzymes (DUBs) regulate the deubiquitinylation process of post-translationally modified proteins and thus control protein signaling in various cellular processes. …”
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    Structural Dynamics of Lys11-Selective Deubiquitinylase Cezanne-1 during the Catalytic Cycle
  7. 247
    “…We included 46,337 subjects with newly diagnosed DUB (ICD-9-CM codes 626.8) from January 1, 1997 to December 31, 2010. …”
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    The utilization of traditional Chinese medicine in patients with dysfunctional uterine bleeding in Taiwan: a nationwide population-based study
  8. 248
    “…We identified multiple and specific DUBs inhibited by BA either in PCa cells or using recombinant DUBs. …”
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    Inhibiting Multiple Deubiquitinases to Reduce Androgen Receptor Expression in Prostate Cancer Cells
  9. 249
    “…The tumor suppressor and deubiquitinase (DUB) BAP1 and its Drosophila ortholog Calypso assemble DUB complexes with the transcription regulators Additional sex combs-like (ASXL1, ASXL2, ASXL3) and Asx respectively. …”
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    Monoubiquitination of ASXLs controls the deubiquitinase activity of the tumor suppressor BAP1
  10. 250
    “…There is a growing body of evidence that UCH-L1 de-ubiquitinating (DUB) activity plays a major pro-metastatic role in certain carcinomas. …”
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    Inhibition of UCH-L1 Deubiquitinating Activity with Two Forms of LDN-57444 Has Anti-Invasive Effects in Metastatic Carcinoma Cells
  11. 251
    “…Metastasis and chemoresistance are major causes of poor prognosis in patients with esophageal squamous cell carcinoma (ESCC), manipulated by multiple factors including deubiquitinating enzyme (DUB). DUB PSMD14 is reported to be a promising therapeutic target in various cancers. …”
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    The PSMD14 inhibitor Thiolutin as a novel therapeutic approach for esophageal squamous cell carcinoma through facilitating SNAIL degradation
  12. 252
    “…Among these three enzymes, PLpro exhibits both proteolytic and deubiquitinase (DUB) activity and is responsible for disrupting the host’s innate immune response against SARS-CoV-2. …”
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    Inhibitory effect of phytochemicals towards SARS-CoV-2 papain like protease (PLpro) proteolytic and deubiquitinase activity
  13. 253
    “…RESULTS: In this study, we used a combination of structure based virtual screening and an in vitro deubiquitinase (DUB) assay to identify several small molecules that inhibit TRABID DUB activity. …”
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    Identification Of Small Molecule TRABID Deubiquitinase Inhibitors By Computation-Based Virtual Screen
  14. 254
    “…Deubiquitinating enzymes (DUBs) control vital processes in eukaryotes by hydrolyzing ubiquitin adducts. …”
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    Mechanism of UCH-L5 Activation and Inhibition by DEUBAD Domains in RPN13 and INO80G
  15. 255
    por March, Eduardo, Farrona, Sara
    Publicado 2018
    “…We describe current knowledge in the molecular and functional characterisation of DUB proteins, focusing primarily on Arabidopsis thaliana. …”
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    Plant Deubiquitinases and Their Role in the Control of Gene Expression Through Modification of Histones
  16. 256
    “…DUBs play several functional roles other than deubiquitination. …”
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    Deubiquitinating enzymes as cancer biomarkers: new therapeutic opportunities?
  17. 257
    “…Ubiquitin chain specificity has been described for some deubiquitinases (DUBs) but lacks a comprehensive profiling in vivo. …”
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    Ubiquitin Linkage Specificity of Deubiquitinases Determines Cyclophilin Nuclear Localization and Degradation
  18. 258
    “…Many of its virulence factors function as ubiquitin ligases or deubiquitinases (DUBs). Here, we identify Lem27 as a DUB that displays a preference for diubiquitin formed by K6, K11, or K48. …”
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    Interplay between bacterial deubiquitinase and ubiquitin E3 ligase regulates ubiquitin dynamics on Legionella phagosomes
  19. 259
    “…Yeast Doa4, a deubiquitylating enzyme (DUB), removes ubiquitin from membrane proteins destined for vacuolar degradation. …”
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    A conserved late endosome–targeting signal required for Doa4 deubiquitylating enzyme function
  20. 260
    “…Isopeptidase activity releases PLA(2), which cleaves its substrate, generating a signal that is linear with deubiquitylase (DUB) concentration and is able to discriminate DUB, deSUMOylase, deNEDDylase, and deISGylase activities. …”
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    Characterization of ubiquitin and ubiquitin-like-protein isopeptidase activities
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