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Mostrando 261 - 280 Resultados de 1,929 Para Buscar '"Dub"', tiempo de consulta: 0.15s Limitar resultados
  1. 261
    “…Both Ubp9 and Ubp13 interacted directly with Duf1 (DUB-associated factor 1), a WD40 motif-containing protein. …”
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    A Deubiquitylating Complex Required for Neosynthesis of a Yeast Mitochondrial ATP Synthase Subunit
  2. 262
    por Verrijzer, C. Peter
    Publicado 2022
    “…These findings suggest that PR-DUB ensures just-right levels of H2Aub1 to allow chromatin compaction by cPRC1.…”
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    Goldilocks meets Polycomb
  3. 263
    “…Histone H2A lysine 119 (H2AK119Ub) is monoubiquitinated by Polycomb repressive complex 1 and deubiquitinated by Polycomb repressive deubiquitinase complex (PR-DUB). PR-DUB cleaves H2AK119Ub to restrict focal H2AK119Ub at Polycomb target sites and to protect active genes from aberrant silencing. …”
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    Structural basis of histone H2A lysine 119 deubiquitination by Polycomb repressive deubiquitinase BAP1/ASXL1
  4. 264
    “…Deubiquitinating enzymes (DUBs) disassemble ubiquitin chains and remove ubiquitin moieties from proteins. …”
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    Effects of selected deubiquitinating enzyme inhibitors on the proliferation and motility of lung cancer and mesothelioma cell lines
  5. 265
    “…Notably, by utilizing the DUB-defective C111 mutant, we demonstrated that SCoV2-PLpro targeted RLR signaling pathway regulators via deubiquitination-dependent and -independent mechanisms, with the inhibitory activities of RIG-I and TBK1 correlating with DUB function, whereas the antagonism effects on MAVS, TRAF3, TRAF6, and IRF3 independent on DUB activity. …”
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    Papain-like protease of SARS-CoV-2 inhibits RLR signaling in a deubiquitination-dependent and deubiquitination-independent manner
  6. 266
    “…Pathogens can regulate eukaryotic proteolysis through the delivery of proteins with de-ubiquitinating (DUB) activities. The obligate intracellular pathogen Chlamydia trachomatis secretes Cdu1 (ChlaDUB1), a dual deubiquitinase and Lys-acetyltransferase, that promotes Golgi remodeling and survival of infected host cells presumably by regulating the ubiquitination of host and bacterial proteins. …”
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    The acetylase activity of Cdu1 regulates bacterial exit from infected cells by protecting Chlamydia effectors from degradation
  7. 267
    “…The deubiquitinating enzyme OTUB1 possesses canonical deubiquitinase (DUB) activity and noncanonical, catalytic-independent activity, which has been identified as an essential regulator of diverse physiological processes. …”
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    SET7 methylates the deubiquitinase OTUB1 at Lys (122) to impair its binding to E2 enzyme UBC13 and relieve its suppressive role on ferroptosis
  8. 268
    “…These observations raise the question of whether a DUB can control the fate of a nonubiquitinated ERAD substrate. …”
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    A deubiquitinase negatively regulates retro-translocation of nonubiquitinated substrates
  9. 269
    “…These data reveal a new mechanism of metabolite regulation of DUB activity and inflammatory signaling.…”
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    Metabolic control of BRISC-SHMT2 assembly regulates immune signaling
  10. 270
    “…Deubiquitinating enzymes (DUBs), ~100 of which are found in human cells, are proteases that remove ubiquitin conjugates from proteins, thereby regulating protein turnover. …”
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    Integrating multi-omics data reveals function and therapeutic potential of deubiquitinating enzymes
  11. 271
    “…Meanwhile, the Linker region of dTrbd is involved in modulating its condensation, a functional state representing the Dub enzymatical activity of dTrbd. Of interest, the activated IMD signals following bacterial stimuli enhance the dTrbd/dTak1 interaction, as well as the condensate assembly and Dub enzymatical activity of dTrbd. …”
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    A Feedback Regulatory Loop Involving dTrbd/dTak1 in Controlling IMD Signaling in Drosophila Melanogaster
  12. 272
    “…Deubiquitinases (DUBs) are required for the reverse reaction of ubiquitination and act as major regulators of ubiquitin signaling processes. …”
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    Mechanisms orchestrating the enzymatic activity and cellular functions of deubiquitinases
  13. 273
    por Haq, Saba, Ramakrishna, Suresh
    Publicado 2017
    “…Deubiquitylating enzymes (DUBs) reverse the ubiquitylation of target proteins, thereby regulating diverse cellular functions. …”
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    Deubiquitylation of deubiquitylases
  14. 274
    “…Together, this makes vDUBs highly attractive antiviral drug targets. However, structural similarity between the catalytic cores of vDUBs and human DUBs complicates the development of selective small molecule vDUB inhibitors. …”
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    Potent and selective inhibition of pathogenic viruses by engineered ubiquitin variants
  15. 275
    “…Loss of DUB activity was tightly linked to lowered pR-Ub modification of Rtn4, consistent with the DUB activity fueling the production of pR-Ub-Rtn4. …”
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    Sde Proteins Coordinate Ubiquitin Utilization and Phosphoribosylation to Promote Establishment and Maintenance of the Legionella Replication Vacuole
  16. 276
    “…USP25 mutants lacking DUB activity lost the ability to block virus-induced type I IFN to some degree. …”
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    Ubiquitin-Specific Proteases 25 Negatively Regulates Virus-Induced Type I Interferon Signaling
  17. 277
    “…Here we show that, in breast cancer cells, KLF5 is stabilized by the deubiquitinase (DUB) BAP1. With a genome-wide siRNA library screen of DUBs, we identify BAP1 as a bona fide KLF5 DUB. …”
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    BAP1 promotes breast cancer cell proliferation and metastasis by deubiquitinating KLF5
  18. 278
    “…BACKGROUND: Dysfunctional uterine bleeding (DUB) is one of the most common gynecological disorders encountered in women during the reproductive age. …”
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    Yoga as a Therapeutic Intervention in the Management of Dysfunctional Uterine Bleeding: A Controlled Pilot Study
  19. 279
    “…Usp9x knockdown, as well as inhibition with DUB inhibitor, G9, blocked SOX2 expression, suppressed in vitro colony growth, and induced apoptosis of BRAF-mutant melanoma cells. …”
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    Downregulation of SOX2 by inhibition of Usp9X induces apoptosis in melanoma
  20. 280
    “…The SAGA (Spt Ada Gcn5 Acetyl-transferase) is a transcriptional coactivator and its DUB module removes ub from H2Bub1. The mammalian SAGA DUB module has four subunits, ATXN7, ATXN7L3, USP22, and ENY2. …”
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    SAGA-Dependent Histone H2Bub1 Deubiquitination Is Essential for Cellular Ubiquitin Balance during Embryonic Development
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