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Mostrando 281 - 300 Resultados de 1,929 Para Buscar '"Dub"', tiempo de consulta: 0.38s Limitar resultados
  1. 281
    por Selby, Sarah T., Haughey, Marianne
    Publicado 2013
    “…Dysfunctional uterine bleeding (DUB) is a common presentation in the emergency department and has a wide differential. …”
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    Uterine Arteriovenous Malformation with Sudden Heavy Vaginal Hemmorhage
  2. 282
    “…However, the interplay of chromatin modifiers and deubiquitinase (DUB) in ferroptosis remains unclear. Here, we found that ubiquitin‐specific protease 5 (USP5) is regarded as a bona fide DUB of lymphoid‐specific helicase (LSH), a DNA methylation repressor, in hepatocellular carcinoma (HCC). …”
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    The ubiquitin‐specific protease 5 mediated deubiquitination of LSH links metabolic regulation of ferroptosis to hepatocellular carcinoma progression
  3. 283
    “…The present study examins the anti‐tumor effects of deubiquitylating enzymes (DUB) inhibitors in HCC. It is found that the inhibitor of ubiquitin specific peptidase 8 (USP8) and DUB‐IN‐3 shows the most effective anti‐cancer responses. …”
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    Targeting USP8 Inhibits O‐GlcNAcylation of SLC7A11 to Promote Ferroptosis of Hepatocellular Carcinoma via Stabilization of OGT
  4. 284
    “…Although deubiquitylating (deubiquitinating) enzymes (DUBs) play a key role in this process, however, their function and regulation remain insufficiently understood. …”
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    Genome-wide loss-of-function analysis of deubiquitylating enzymes for zebrafish development
  5. 285
    “…To examine the role of DUBs during norovirus infection, we used WP1130, a small molecule inhibitor of a subset of cellular DUBs. …”
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    Antiviral Activity of a Small Molecule Deubiquitinase Inhibitor Occurs via Induction of the Unfolded Protein Response
  6. 286
    “…However, it remains unclear which deubiquitylating enzyme (DUB) removes H2AK13,15ub. Here we show that USP51, a previously uncharacterized DUB, deubiquitylates H2AK13,15ub and regulates DNA damage response. …”
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    USP51 deubiquitylates H2AK13,15ub and regulates DNA damage response
  7. 287
    “…USP37 is a deubiquitinase (DUB) with roles in the regulation of DNA damage repair and the cohesion of sister chromatids during mitosis. …”
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    The ubiquitin interacting motifs of USP37 act on the proximal Ub of a di-Ub chain to enhance catalytic efficiency
  8. 288
    “…HSV1 ΔDUB also induced elevated IFN expression in murine and human microglia and exhibited reduced viral replication in the brain. …”
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    HSV1 VP1-2 deubiquitinates STING to block type I interferon expression and promote brain infection
  9. 289
    “…Ubiquitination, and its control by deubiquitinating enzymes (DUBs), mediates protein stability, function, signaling and cell fate. …”
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    Ubiquitin-dependent and -independent functions of OTULIN in cell fate control and beyond
  10. 290
    “…Distinct families of eukaryotic deubiquitinases (DUBs) are regulators of ubiquitin signaling. Here, we report on the presence of an additional DUB class broadly distributed in eukaryotes and several bacteria. …”
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    A widely distributed family of eukaryotic and bacterial deubiquitinases related to herpesviral large tegument proteins
  11. 291
    “…We used a 74-DUB library-based yeast two-hybrid assay and determined that a novel DUB, valosin-containing protein-interacting protein 1 (VCPIP1), interacted with HBx. …”
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    Hepatitis B Virus X Protein Is Stabilized by the Deubiquitinating Enzyme VCPIP1 in a Ubiquitin-Independent Manner by Recruiting the 26S Proteasome Subunit PSMC3
  12. 292
    “…Our review provides a framework to understand key aspects of DUB biology.…”
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    The structure and function of deubiquitinases: lessons from budding yeast
  13. 293
    “…CL was correlated with the Dubousset’s lumbosacral angle (Dub-LSA), pelvic tilt (PT), and thoracic kyphosis (TK). …”
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    Cervical sagittal alignment in adolescent high dysplastic developmental spondylolisthesis: how does the cervical spine respond to the reduction of spondylolisthesis?
  14. 294
    “…An immunofluorescence-based screening of an shRNA library allowed us to identify eIF3f, previously known as one of the subunits of the translation initiation factor eIF3, as a DUB targeting the activated Notch receptor. We show that eIF3f has an intrinsic DUB activity. …”
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    The Translation Initiation Factor 3f (eIF3f) Exhibits a Deubiquitinase Activity Regulating Notch Activation
  15. 295
    “…Using active site-directed probes, we show that one of these putative DUBs, the conserved herpesvirus large tegument protein BPLF1, acts as a functional DUB in EBV-producing B cells. …”
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    Epstein-Barr Virus Large Tegument Protein BPLF1 Contributes to Innate Immune Evasion through Interference with Toll-Like Receptor Signaling
  16. 296
    “…In addition, we demonstrated that in contrast to USP15 de-ubiquitinating (DUB) activity, USP15-mediated inhibition of IFN signaling was not abolished by mutations eliminating the catalytic activity, indicating that a fraction of USP15-mediated IFN antagonism was independent of the DUB activity. …”
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    Ubiquitin-specific Protease 15 Negatively Regulates Virus-induced Type I Interferon Signaling via Catalytically-dependent and -independent Mechanisms
  17. 297
    “…Mass spectrometry technology has now reached the capacity to cover the proteome with enough depth to interrogate entire biochemical pathways including those that contain DUBs and E3 ligase substrates. We have recently characterized the breast cancer cell (MCF7) deep proteome by detecting and quantifying ~10,000 proteins, and within this data set, we can detect endogenous expression of 65 deubiquitylating enzymes (DUBs), whereas matching transcriptomics detected 78 DUB mRNAs. …”
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    Comprehensive Landscape of Active Deubiquitinating Enzymes Profiled by Advanced Chemoproteomics
  18. 298
    “…Deubiquitinates (DUBs) have been suggested as novel promising targets for cancer therapies. …”
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    Regulation of Bax-dependent apoptosis by mitochondrial deubiquitinase USP30
  19. 299
    “…To understand its physics, we compute ghost-mediated scatterings among matter particles at tree-level, finding a new power-like infra-red enhancement typical of 4-derivative theories, that we dub ‘ghostrahlung’. Super-Planckian scatterings get downgraded to Planckian by radiating hard gravitons and ghosts, which are weakly coupled and carry away the energy.…”
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    New infra-red enhancements in 4-derivative gravity
  20. 300
    por Kowalski, Jennifer R., Juo, Peter
    Publicado 2012
    “…The importance of DUB function at the synapse is underscored by the association of specific mutations in DUB genes with several neurological disorders. …”
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    The Role of Deubiquitinating Enzymes in Synaptic Function and Nervous System Diseases
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