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Mostrando 301 - 320 Resultados de 1,929 Para Buscar '"Dub"', tiempo de consulta: 0.11s Limitar resultados
  1. 301
    por Penn, Ying Ying
    Publicado 2018
    “…A 17-year-old girl with a history of dysfunctional uterine bleeding (DUB) and severe dysmenorrhoea was treated with different conventional hormonal therapies for 16 months without improvement. …”
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    Acupuncture treatment for dysfunctional uterine bleeding in an adolescent
  2. 302
    “…Here, we briefly discuss the pathophysiological and physiological roles of DUBs in key cancer-related pathways. We also discuss the clinical applications of promising DUB inhibitors that may contribute to the development of DUBs as key therapeutic targets in the future.…”
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    Advances in Deubiquitinating Enzyme Inhibition and Applications in Cancer Therapeutics
  3. 303
    por Liu, Sijia, ten Dijke, Peter
    Publicado 2020
    “…We developed a specific DUB activity-based inhibitor and probe and applied it to obtain new insights into breast cancer.…”
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    Uncovering the deubiquitinase activity landscape of breast cancer
  4. 304
    “…E3 ubiquitin ligases (E3s) and deubiquitinating enzymes (DUBs) play key roles in protein degradation. However, a large number of E3 substrate interactions (ESIs) and DUB substrate interactions (DSIs) remain elusive. …”
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    Deep-learning based approach to identify substrates of human E3 ubiquitin ligases and deubiquitinases
  5. 305
    por Tu, Xiang, Huang, Gaomin, Tan, Shengkui
    Publicado 2009
    “…We conducted a systematic review to evaluate the efficacy and safety of Chinese herbal medicine (CHM) for dysfunctional uterine bleeding (DUB) by performing a meta-analysis. Randomized controlled trials (RCTs) or quasi-RCTs comparing CHM vs no treatment, placebo, conventional western medicine (CWM), or general non-specific surgical treatment for DUB were identified by electronic and manual searches. …”
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    Texto
    Chinese Herbal Medicine for Dysfunctional Uterine Bleeding: a Meta-analysis
  6. 306
    “…In eukaryotes, deubiquitinases (DUBs) remove ubiquitin conjugates from diverse substrates, altering their stabilities, localizations or activities. …”
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    Reversible inactivation of deubiquitinases by reactive oxygen species in vitro and in cells
  7. 307
    “…Here, we show that FOXK2 binds to the SIN3A and PR-DUB complexes. The PR-DUB complex contains the important tumour suppressor protein, the deubiquitinase BAP1. …”
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    The forkhead transcription factor FOXK2 acts as a chromatin targeting factor for the BAP1-containing histone deubiquitinase complex
  8. 308
    “…Although it is known that DSB repair pathways are tightly regulated by ubiquitylation, we do not yet have a comprehensive understanding of how deubiquitylating enzymes (DUBs) function in DSB responses. Here, by carrying out a multi-dimensional screening strategy for human DUBs, we identify several with hitherto unknown links to DSB repair, the G2/M DNA-damage checkpoint and genome-integrity maintenance. …”
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    Systematic characterization of deubiquitylating enzymes for roles in maintaining genome integrity
  9. 309
    “…Recently, we have reported that the anti-cancer activity of copper (II) pyrithione CuPT and gold (I) complex auranofin is associated with targeting the 19S proteasome-associated deubiquitinases (DUBs), UCHL5 and USP14. Here we discuss metal DUB inhibitors in treating cancer and other diseases. …”
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    Inhibition of 19S proteasome-associated deubiquitinases by metal-containing compounds
  10. 310
    “…However, the deubiquitinase (DUB) of KLF5 has not been demonstrated. In this study, we identified ATXN3L as a KLF5 DUB by genome-wide siRNA screening. …”
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    Ataxin-3 like (ATXN3L), a member of the Josephin family of deubiquitinating enzymes, promotes breast cancer proliferation by deubiquitinating Krüppel-like factor 5 (KLF5)
  11. 311
    “…Deubiquitinating enzymes (DUBs) are important regulators of ubiquitin signaling. …”
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    Discovery and Characterization of ZUFSP/ZUP1, a Distinct Deubiquitinase Class Important for Genome Stability
  12. 312
    “…Here, we conducted comprehensive gain- and loss-of-function screens using a human DUB cDNA library of 65 genes and an siRNA library of 98 genes, and identified USP20 as a deubiquitinase (DUB) that regulates SNAI2 ubiquitination and stability. …”
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    Deubiquitinase USP20 promotes breast cancer metastasis by stabilizing SNAI2
  13. 313
    “…Here, we demonstrate that the deubiquitinating enzyme (DUB) ubiquitin-specific protease 8 (USP8) stabilizes the Wnt receptor frizzled 5 (FZD5) by preventing its lysosomal degradation. …”
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    Deubiquitinating Enzyme USP8 Is Essential for Skeletogenesis by Regulating Wnt Signaling
  14. 314
    “…Using an siRNA library targeting 96 human DUBs, we identified UCHL1 as a putative regulator of ACE2 function as a viral receptor. …”
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    Inhibiting the Deubiquitinase UCHL1 Reduces SARS-CoV-2 Viral Uptake by ACE2
  15. 315
    “…Using quantitative mass spectrometry, we found that all UTX isoforms integrated into the MLL3 and MLL4, PR-DUB and MiDAC complexes. Interestingly, one of the novel UTX isoforms, which lacks exons 14 and 16, fails to interact with PR-DUB and MiDAC complex members. …”
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    Alternative mRNA Splicing Controls the Functions of the Histone H3K27 Demethylase UTX/KDM6A
  16. 316
    “…Ubiquitination is a specific protein degradation and reversible post-translational modification process that can be reversed by deubiquitinase (DUBs). DUBs can hydrolyze and release ubiquitin in the substrate protein so that the substrate can avoid degradation or change its activity, and it has an impact on plant growth and development, cell cycle, abiotic stress response, and other biological processes. …”
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    RNA-seq provides insights into potato deubiquitinase responses to drought stress in seedling stage
  17. 317
    “…It is, however, unknown whether the DUB catalytic activity of MYSM1 is universally required for its many functions and for the maintenance of hematopoiesis in vivo. …”
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    Deubiquitinase catalytic activity of MYSM1 is essential in vivo for hematopoiesis and immune cell development
  18. 318
    “…BAP1 and ASXL1, subunits that form active PR-DUB, are among the most frequently mutated epigenetic factors in human cancers, underscoring their biological importance. …”
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    Structural basis of histone H2A lysine 119 deubiquitination by Polycomb Repressive Deubiquitinase BAP1/ASXL1
  19. 319
    “…Importantly, the inhibition of Nrf2, directly or through inhibition of DUB3, reverted the resistance to targeted therapies.…”
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    Nrf2 as a Therapeutic Target in the Resistance to Targeted Therapies in Melanoma
  20. 320
    “…Ubiquitination can alter protein functions and/or mark ubiquitinated proteins for proteasomal degradation but deubiquitinases (DUBs) can reverse protein ubiquitination. While the importance of DUBs as regulatory factors in the UPS is undisputed, many questions remain on DUB selectivity for protein targeting, their mechanism of action, and the impact of DUBs on the regulation of diverse biological processes. …”
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    DUBing Primary Tumors of the Central Nervous System: Regulatory Roles of Deubiquitinases
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