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Mostrando 341 - 360 Resultados de 1,929 Para Buscar '"Dub"', tiempo de consulta: 0.11s Limitar resultados
  1. 341
    “…The methods used revealed apparent differences between Yeast and A. nidulans in the deubiquitination (DUB) module of the complex, which in S. cerevisiae consists of Sgf11p, Sus1p, and Ubp8p. …”
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    Online Artículo Texto
    The Spt-Ada-Gcn5 Acetyltransferase (SAGA) Complex in Aspergillus nidulans
  2. 342
    “…Here we performed a genetic screen to determine what DUB, if any, antagonizes the function of the APC/C in the fission yeast Schizosaccharomyces pombe. …”
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    Online Artículo Texto
    Histone H2B Ubiquitination Promotes the Function of the Anaphase-Promoting Complex/Cyclosome in Schizosaccharomyces pombe
  3. 343
    “…Usp5 is a deubiquitinase (DUB) previously shown to regulate unanchored polyubiquitin (Ub) chains, p53 transcriptional activity and double-strand DNA repair. …”
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    Online Artículo Texto
    Usp5 links suppression of p53 and FAS levels in melanoma to the BRAF pathway
  4. 344
    “…Understanding function and specificity of de-ubiquitylating enzymes (DUBs) is a major goal of current research, since DUBs are key regulators of ubiquitylation events and have been shown to be mutated in human diseases. …”
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    Online Artículo Texto
    Evolutionary Loss of Activity in De-Ubiquitylating Enzymes of the OTU Family
  5. 345
    “…Inhibition of proteasome-associated deubiquitinases (DUBs) is emerging as a novel strategy for cancer therapy. …”
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    Online Artículo Texto
    Two clinical drugs deubiquitinase inhibitor auranofin and aldehyde dehydrogenase inhibitor disulfiram trigger synergistic anti-tumor effects in vitro and in vivo
  6. 346
    “…We recently described the small molecule VLX1570 as an inhibitor of proteasome deubiquitinase (DUB) activity that induces proteotoxic stress and apoptosis in cancer cells. …”
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    Online Artículo Texto
    Acute lymphoblastic leukemia cells are sensitive to disturbances in protein homeostasis induced by proteasome deubiquitinase inhibition
  7. 347
    “…The tumor suppressor BRCA1-associated protein 1 (BAP1) encodes a nuclear de-ubiquitinating (DUB) enzyme to reduce histone 2A ubiquitination (H2Aub) on chromatin. …”
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    BAP1 links metabolic regulation of ferroptosis to tumor suppression
  8. 348
    “…CONCLUSIONS: Our study reveals that RTHF-mediated inhibition of DUBs and proteasome may provide a potential strategy for cancer therapy.…”
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    Online Artículo Texto
    Radix Tetrastigma Hemsleyani Flavone Suppresses Cutaneous Squamous Cell Carcinoma A431 Cells via Proteasome Inhibition
  9. 349
    “…Marek’s disease virus (MDV) encodes a viral DUB that plays an important role in the MDV pathogenicity. …”
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    Online Artículo Texto
    Marek’s Disease Virus Regulates the Ubiquitylome of Chicken CD4(+) T Cells to Promote Tumorigenesis
  10. 350
    por Yao, Fan, Xiao, Zhenna, Sun, Yutong, Ma, Li
    Publicado 2018
    “…Moreover, by screening ubiquitin E3 ligases implicated in K63-linked ubiquitination and a human deubiquitinase (DUB) library, we identified the SCF(SKP2 )complex and OTUD1, respectively, as the E3 ligase and the DUB that regulate this non-proteolytic ubiquitination without altering YAP protein level. …”
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    Online Artículo Texto
    SKP2 and OTUD1 govern non-proteolytic ubiquitination of YAP that promotes YAP nuclear localization and activity
  11. 351
    “…These findings suggest a mitochondrial origin of the increased levels of ROS observed in cells exposed to the DUB inhibitor b-AP15.…”
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    Online Artículo Texto
    Oxidative Stress Induced by the Deubiquitinase Inhibitor b-AP15 Is Associated with Mitochondrial Impairment
  12. 352
    “…Deubiquitinating enzymes (DUBs) function to remove or cleave ubiquitin from post-translationally modified protein substrates. …”
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    Online Artículo Texto
    Recent Developments in Cell Permeable Deubiquitinating Enzyme Activity-Based Probes
  13. 353
    “…Thus, our study uncovered a viral DUB which coronaviruses may use to escape from the host innate antiviral responses. …”
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    Online Artículo Texto
    PLP2, a potent deubiquitinase from murine hepatitis virus, strongly inhibits cellular type I interferon production
  14. 354
    “…The reversibility of ubiquitination by the action of deubiquitinating enzymes (DUBs) serves as an important regulatory layer within the ubiquitin system. …”
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    Online Artículo Texto
    Deubiquitinating enzyme amino acid profiling reveals a class of ubiquitin esterases
  15. 355
    “…This strategy led to the identification of small molecule inhibitors of deubiquitinating enzymes (DUBs) as potent inducers of actin polymerization and blockers of chemotactic cell migration. …”
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    Online Artículo Texto
    Deubiquitinase Inhibitors Impair Leukemic Cell Migration Through Cofilin Oxidation and Alteration of Actin Reorganization
  16. 356
    “…Here, we report that the SAGA DUB module and TREX-2 distinctly regulate yeast replicative lifespan in a Sir2-dependent and -independent manner, respectively. …”
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    Online Artículo Texto
    Sus1 maintains a normal lifespan through regulation of TREX-2 complex-mediated mRNA export
  17. 357
    “…The purpose of this study was to investigate the effect and mechanism of action of the USP8 inhibitor DUB-IN-1 on GBM.…”
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    Online Artículo Texto
    Pharmacological inhibition of the ubiquitin-specific protease 8 effectively suppresses glioblastoma cell growth
  18. 358
    “…The human genome encodes ~100 deubiquitinating enzymes (DUBs), which antagonistically regulate the ubiquitin system. …”
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    Online Artículo Texto
    Pleiotropic Roles of a KEAP1-Associated Deubiquitinase, OTUD1
  19. 359
    “…The main characteristic of this interface, which we dub aMCfast, is its being fully automated as well, which removes the need to extract manually the process-specific information for additional physics processes, as is the case with other matrix element calculators, and renders it straightforward to include any new process in the PDF fits. …”
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    aMCfast: automation of fast NLO computations for PDF fits
  20. 360
    “…This mechanism, which we dub wash-in leptogenesis, does not require any CP violation in the neutrino sector and can be implemented even in the regime of strong wash-out. …”
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    Wash-In Leptogenesis
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