Mostrando 21 - 40 Resultados de 1,929 Para Buscar '"Dub"', tiempo de consulta: 0.14s Limitar resultados
  1. 21
    Repositorio institucional.
    Tesis Electrónico eBook
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    por Kulathu, Yogesh
    Publicado 2016
    “…Linkage-specific DUBs employ different mechanisms to recognize and cleave polyubiquitin chains of specific linkage types. …”
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  5. 25
    “…Deubiquitinating enzymes (DUBs) reverse Ub signaling by disassembly of one or multiple poly-Ub chain types and their malfunction is often associated with human disease. …”
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  6. 26
    por Zheng, Wenqing, Du, Liang
    Publicado 2021
    “…BACKGROUND: The deubiquitinase (DUB) family constitutes a group of proteases that regulate the stability or reverse the ubiquitination of many proteins in the cell. …”
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  7. 27
    por Snyder, Nathan A., Silva, Gustavo M.
    Publicado 2021
    “…Many DUBs selectively regulate physiological pathways employing conserved mechanisms of ubiquitin bond cleavage. …”
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  8. 28
    “…Many DUBs are well characterized in the human system with potential drug targets in different cancers. …”
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  9. 29
    por Liu, Na, Lin, Miao-Miao, Wang, Yan
    Publicado 2022
    “…An increasing number of E3 ubiquitin ligases (E3s) and deubiquitinating enzymes (DUBs) have been observed to participate in the pathogenesis mechanisms of neurodegenerative diseases, on the basis of which we conducted a systematic literature review of the studies. …”
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  10. 30
    “…We recently reported a multifaceted study of the fission yeast Schizosaccharomyces pombe DUBs including characterization of their binding partners, in vitro enzymatic activity and subcellular localization.(1) Over half of the 20 fission yeast DUBs have a stable protein partner and some of those partners regulate the localization and/or activity of their cognate DUB. …”
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  11. 31
    por Herhaus, Lina, Sapkota, Gopal P.
    Publicado 2014
    “…This review will provide a concise summary of our current understanding of how DUBs regulate TGFβ signalling.…”
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  12. 32
    por Ruan, Jing, Schlüter, Dirk, Wang, Xu
    Publicado 2020
    “…Studies with experimental autoimmune encephalomyelitis (EAE), an animal model of MS, have provided biological rationale for the correlation between these DUBs and MS. Additional studies have shown that other DUBs are also involved in EAE by controlling distinct cell populations. …”
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    por Gómez Quintanar, Adriana
    Publicado 2017
    Tesis Electrónico eBook
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    “…Using a siRNA library directed at the full complement of human DUBs, we identified POH1 (also known as Rpn11 or PSMD14), a component of the proteasome lid, as a critical DUB controlling the apparent ErbB2 levels. …”
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  17. 37
    “…METHODOLOGY/PRINCIPAL FINDINGS: To elucidate the functional role of Dub-2, we generated genetically modified mice by introducing neo cassette into the second exon of Dub-2 and then homologous recombination was done to completely abrogate the activity of DUB-2 proteins. …”
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    “…In this study, we investigated the role of SAGA-DUB’s Ubp8-driven deubiquitylation of the centromeric histone variant Cse4 in budding yeast. …”
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